In vitro analysis of the effect of benzo-a-pyrene on sperm hyperactivation

Gutgutia, Rohit; Mukhopadhyay, D.; Nandi, Parag; Bhattacharyya, A.; Banerjee, S. K.; Agarwal, Ashok

doi:10.1016/j.fertnstert.2008.07.749

Cited by 1 publication

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“…BaP can also cause an increase in sperm hyperactivation that is essential for sperm cells for acquisition of fertilising capability, resulting in premature and erroneous acrosome reaction. Using normospermic semen samples from nonsmoking men, Gutgutia et al () have shown that increased concentrations of BaP (≥50 μg/ml) lead to an increase in sperm hyperactivation, promoting a premature and erroneous acrosome reaction.…”

Section: Components Of Cigarette Smokementioning

confidence: 99%

Smoking-induced genetic and epigenetic alterations in infertile men

et al. 2018

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Male fertility rates have shown a progressive decrease in both developing and industrialised countries in the past 50 years. Clinical and epidemiological studies have demonstrated controversial results about the harmful effects of cigarette smoking on seminal parameters. Some studies could not establish a negative effect by tobacco smoking on sperm quality and function, whereas others have found a significant reduction in sperm quality and function. This study reviews the components in cigarette smoke and discusses the effects of smoking on male fertility by focusing extensively on smoking-induced genetic and epigenetic alterations in infertile men. Chromosomal aneuploidies, sperm DNA fragmentation and gene mutations are discussed in the first section, while changes in DNA methylation, chromatin remodelling and noncoding RNAs are discussed in the second section as part of epigenetic alterations.

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Section: Components Of Cigarette Smokementioning

confidence: 99%