In vitro and in vivo application of hydroxypropyl-β-cyclodextrin-grafted polyethyleneimine used as a transdermal penetration enhancer

Wang, Ke; Yan, Yan; Zhao, Guilan; Xu, Wei; Dong, Kai; You, Cuiyu; Zhang, Lu; Xing, Jianfeng

doi:10.1039/c4py00286e

Cited by 22 publications

(11 citation statements)

References 36 publications

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“…Wang et al (2014) studied the effect of polymers based on β-cyclodextrins as chemical enhancers for transdermal therapy (Wang et al, 2014). ATR-FTIR studies using stratum corneum from mice skin tissues were performed.…”

Section: Attenuated Total Reflectance Fourier-transform Infrared Specmentioning

confidence: 99%

Section: Studies Of Cutaneous Retentionmentioning

confidence: 99%

“…The authors studied isolated skin layers (epidermis and stratum corneum) and used ATR-FTIR to characterize the Fickian diffusion of the molecule through the skin. Wang et al (2014) studied the effect of polymers based on β-cyclodextrins as chemical enhancers for transdermal therapy (Wang et al, 2014). ATR-FTIR studies using stratum corneum from mice skin tissues were performed.…”

Section: Attenuated Total Reflectance Fourier-transform Infrared Specmentioning

confidence: 99%

“…Next, the epidermis is detached from the dermis. The stratum corneum also can be isolated by immersing the whole skin in a trypsin solution at 37 °C for 24 h. After digestion of the skin by an enzymatic solution, only the stratum corneum is recovered (Snorradóttir et al, 2011;Mcauley et al, 2013;Wang et al, 2014).Experimental protocols are based on in vitro and in vivo evaluations of skin penetration. These evaluations may be performed in vitro after the skin permeation assays using diffusion cells (Reid et al, 2013, Ruela et al, 2013Paleco et al, 2014;Shah et al, 2015).…”

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confidence: 99%

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Evaluation of skin absorption of drugs from topical and transdermal formulations

Ruela

Perissinato

Lino

et al. 2016

Braz. J. Pharm. Sci.

216

135

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The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of drugs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed. Uniterms:Skin absorption/effects/study. Skin absorption/topical formulations. Skin absorption/ transdermal formulations. Skin absorptions/enhancers. INTRODUCTIONTopical and transdermal drug delivery systems have shown significant advantages in clinical practice for drug targeting to the action site in the body; this has reduced the systemic side effects. The administration of drugs by through the skin is also performed to achieve controlled or prolonged drug delivery, and this route can be explored as an alternative to the oral route. The oral route shows some limitations for drugs with irregular absorption in the gastrointestinal tract and low bioavailability and for drugs with increased first pass metabolism and short plasma halflife times (Barry, 2001;Wokovich et al., 2006;Prausnitz, Langer, 2009;Alexander et al., 2012).Many drug products applied to the skin surface may penetrate to some extent into the skin layers, where their effects are expected. This is the case for topical formulations for treatment of skin disorders such as acne and cutaneous inflammatory diseases that include dermatitis, erythematous lupus, and psoriasis. On the other hand, transdermal formulations release drugs that permeate through the skin and enter the systemic circulation. Transdermal therapy must ensure that significant concentrations of the drug are absorbed to reach effective plasma concentrations. Permeation of drugs is targeted in some cases to body regions close to the action site, where a regional effect is expected, e.g., in the muscles, blood vessels, and articulations. In this way, the term "cutaneous absorption" is properly used to characterize the sum of the amounts of drug that penetrate and permeate the skin (Barry, 2001;El Maghraby, Barry;Willi...

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Section: Attenuated Total Reflectance Fourier-transform Infrared Specmentioning

confidence: 99%

Section: Studies Of Cutaneous Retentionmentioning

confidence: 99%

Section: Attenuated Total Reflectance Fourier-transform Infrared Specmentioning

confidence: 99%

mentioning

confidence: 99%

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Evaluation of skin absorption of drugs from topical and transdermal formulations

Ruela

Perissinato

Lino

et al. 2016

Braz. J. Pharm. Sci.

216

135

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“…Natural CDs and their hydrophilic derivatives present considerable difficulties to permeate lipophilic biological membranes. Even the somewhat lipophilic randomly methylated b-CD does not readily permeate lipophilic membranes, although it interacts more readily with membranes than the hydrophilic CD derivatives (Totterman et al 1997); for this reason some b-CD derivatives have been considered skin enhancers due to their ability to complex membrane components causing its disruption (Babu and Pandit 2004;Wang et al 2014). Several CDs, namely, g-CD, 2-HP-b-CD, Polysaccharides DOI 2014 SBE-b-CD, sulphated b-CD, and maltosyl b-CD evaluated in a number of safety studies have proven that they appear to be safe even when administered parenterally.…”

Section: Toxicological Considerationsmentioning

confidence: 99%

Cyclodextrins

Couto¹,

Salústio²,

Cabral-Marques³

2014

Polysaccharides

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Cyclodextrins (CDs) were first isolated in 1891 as degradation products of starch from a medium of Bacillus amylobacter. They are cyclic water-soluble, nonreducing, macrocycle carbohydrate polymers constructed from a-(1-4)-linked D-glucopyranose units (naturally occurring a, b, and g formed by 6, 7, and 8 glucose units), in a ring formation and present a toroidal, hollow, truncated cone shape. Their most important property is the ability to establish specific interactions -molecular encapsulation -with various types of molecules through the formation of non-covalently bonded entities, either in the solid phase or in aqueous solution, taking up a whole molecule, or some part of it, into their cavities. This process in part mimics the "lock and key" mechanism of enzyme catalysis. Complexation may cause changes in physicochemical properties of the guest molecule (e.g., solubility, stability, kinetics and bioavailability, toxicity). Their negligible cytotoxic effects promoted them to the GRAS list and led them to be widely used in many industrial products and technologies.

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