In vitro and in vivo antidiabetic effect of Andrographis lineata Wall. Ex.Nees and Andrographis serphyllifolia Wt.Ic leaf extracts

Deepa, V. Sudarshana; Rajaram, Kanchana; Kumar, Pardeep

doi:10.5897/ajpp2013.3655

Cited by 5 publications

(3 citation statements)

References 51 publications

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“…The chemical investigation of A. serpyllifolia revealed the presence of serpyllin, a new flavone (Govindachari et al, 1968). Alkaloids, tannins, terpenoids, steroids, flavonoids and polyphenol compounds are the phytochemicals known in A. serpyllifolia by qualitative analysis (Deepa et al, 2013). A. serpyllifolia contain many important phytochemicals, which can act as capping agents in NPs synthesis and reveals the antimicrobial properties.…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

Antimicrobial and mosquito larvicidal activity of iron oxide nanoparticles phytosynthesized from the medicinal plant Andrographis serpyllifolia

SOUNDARYA,

KARMEGAM

2023

Not Sci Biol

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Nanoparticles (NPs) play a significant role in protecting human and environmental health. Worldwide, research is focused on developing new pharmaceuticals and environmentally safe materials. The current research reports the phytosynthesis of NPs from iron oxide (Fe2O3) mediated through ethanolic extracts of Andrographis serpyllifolia leaf (ASL) and their antimicrobial (bacteria and fungi) and mosquito (Culex quinquefasciatus) larvicidal activity. ASL was treated with aqueous iron chloride solution to turn into synthesized Fe2O3-NPs. The biosynthesized ASL·Fe2O3-NPs were characterized with spectroscopic, electron microscopic and X-ray analyses. The synthesized ASL·Fe2O3-NPs were characteristically showed triclinic crystal shape in SEM. The purity of synthesized Fe2O3 nanoparticles was confirmed by FT-IR analysis. Out of twelve different selective pathogens (4 G+ve bacteria, 4 G-ve bacteria and 4 fungal species) tested with ASL·Fe2O3-NPs, a maximum of 20.3 mm inhibition zone against Staphylococcus aureus among G+ve bacteria and 19.1 mm inhibition zone against Pseudomonas aeruginosa among G-ve bacteria was observed; while it was 16.9 mm against fungi (Aspergillus niger) at a test concentration of 100 µL. The exposure of 4th instar larvae for 48 h to ASL·Fe2O3-NPs exhibited a significant LC50 value at 12.80 ppm. The study findings reveal that the Fe2O3‑NPs synthesized using A. serpyllifolia leaf extract could be a potential source for antibacterial, antifungal and mosquito larvicidal activities.

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Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

Antimicrobial and mosquito larvicidal activity of iron oxide nanoparticles phytosynthesized from the medicinal plant Andrographis serpyllifolia

SOUNDARYA,

KARMEGAM

2023

Not Sci Biol

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“…Over time, diabetic patients with poor glycemic control undergo various life threatening difficulties which include nephropathy, retinopathy, neuropathy, and cardiovascular diseases [7]. Alongside with exercise, modern drugs such as pioglitazone, biguanides, meglitinides, thiazolidinedione, alpha glucosidase inhibitors and sulphonylureas shows considerable benefits with side effects like hypoglycemia, GIT disturbance, water intoxication, and hyponatremia, obesity when used for long term [8]. Numerous agents that are currently used for the treatment of type 2 diabetes are facing limited efficacy and tolerability [9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vivo Synergistic Hypoglycemic & Hypolipidemic Activity of Ethanolic Extract of Calotropis gigantean Leaves in Combination to Metformin in Alloxan Induced Rats

Jahan

Akter

Rahman

2019

JOCAMR

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Aim: The present study was designed to investigate the antidiabetic & hypolipidemic activity of Calotropis gigantean (Family: Apocynaceae) in alloxan-induced diabetic rat model. Study Design: In vivo study was carried out by ethanolic leaf extract was administered in 250 mg/kg body weight concentration and then subjected to different rats models to authenticate the antidiabetic and hyperlipidimic properties of the plant. Place and Duration of Study: Department of Pharmacy, Southeast University, Banani, Dhaka-1213,Bangladesh within a period of July 2018 to December, 2018. Methodology: Diabetes was induced in rats by an intraperitoneal injection (i.p) of alloxan (100 mg/kg B.W). Ethanolic leaf extract of C. gigantean (250 mg/kg B.W) was administrated orally as a single dose per day to the diabetic rats for 7 days. The negative control group received 0.5 ml of sterile normal saline water orally & positive control group received metformin orally. Synergistic effect of plant was evaluated by combination with 100 mg/kg B.W & 50 mg/kg B.W oral administration of metformin. After 7 days study period, fasting blood glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, liver weight & body weight were measured only for diabetic group to observe the effects of diabetes induction. Results: Individual plant extract (250 mg/Kg B.W) & Metformin (100 mg/kg B.W) reduced FBG significantly by 52% (P<0.001) & 55.3% (P<0.001) correspondingly. Metformin (100 mg/kg B.W) potentiated reduction (68%) (P<0.001) when combined to plant extract (250 mg/Kg B.W). Significant dose dependent manner was followed when metformin (50 mg/kg B.W) was combined to plant extract (250 mg/Kg B.W). Our results clearly suggests that C. gigantean exhibit hypoglycemic & hypolipidemic activity with an alteration in body-liver weight. The present study also suggested to develop a combination therapy of extract along with metfromin in different doses to minimize the intake of synthetic drug. Significant reduction of TG, TC were noted by extract (250 mg/kg B.W) with 32.42% (P<0.001) & 41.32% (P<0.001) respectively where standard shown the diminution 43.43% (P<0.05) & 47.21% (P<0.001) respectively as compare to Untreated diabetic rats. 50.21% (P<0.01) & 42.38% (P<0.001) reduction of TG & TC were estimated by C.gigantea extracts (250 mg/kg B.W) when combined with Metformin (100 mg/kg B.W). 34.53% (P<0.05) & 41.54% (P<0.001) reduction of TG & TC by C.gigantea extracts (250 mg/kg B.W) were confirmed when combined to Metformin (50 mg/kg B.W). Combination therapy also has shown synergistic effect in elevation of plasma HDL-cholesterol. Conclusion: The results of the study concluded that C. gigantean have potential antidiabetic and antioxidant properties.

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“…[3][4][5] Along with exercise, modern drugs such as pioglitazone, biguanides, meglitinides, thiazolidinedione, alpha glucosidase inhibitors, and sulphonylureas have better efficacy but lead to side effects like hypoglycemia, gastrointestinal tract disturbance, obesity, water intoxication, and hyponatremia with high cost. 6 It has been reported that herbal medicines are gaining popularity to show better efficacy with no or very rare side effects proven by both in vivo and in vitro studies. Various chemical constituents or compounds obtained from medicinal plants have proven their efficacy and safety in the treatment of diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats

Akhtar

Akram

Daniyal

et al. 2018

Int J Immunopathol Pharmacol

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Different allopathic drugs are being used for the treatment of diabetes mellitus but more emphasis are being placed on the use of medicinal plants, herbs, and natural extracts of fruits and vegetables due to their easy availability, easy consummation with low cost, and with no well-reported side effects. White skinned sweet potato (WSSP; Ipomoea batatas L.) peel-off was selected to find out its antidiabetic potential as well as to explore the effects on selected biochemical parameters in diabetes-induced Wistar rats. In young (3–4 months) and old (up to 1 year) diabetic Wistar rats, it was found that WSSP (I. batatas L.) peel-off significantly (P < 0.05) decreased blood glucose level, protein glycation level, total cholesterol, triglycerides, and low-density lipoprotein (LDL)-cholesterol. A significant (P < 0.05) increase in high-density lipoprotein (HDL)-cholesterol level after treatment was also reported. Furthermore, it was also found that WSSP peel-off also had beneficial effects on total protein concentration, albumin, globulin, and liver enzymes (serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT)). It might be concluded that antidiabetic potential of WSSP extract is due to the presence of bioactive compounds like glycoprotein, anthocyanins, alkaloids, and flavonoids, which act as insulin-like molecules or insulin secretagogues constituents in sweet potatoes peel-off and these antidiabetic proteins were extracted out in more concentration in methanol due to its organic nature. Further research is needed to purify and quantify the antidiabetic components responsible for antidiabetic effects of WSSP and it should be available in compact dose form for the treatment of diabetic patients.

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In vitro and in vivo antidiabetic effect of Andrographis lineata Wall. Ex.Nees and Andrographis serphyllifolia Wt.Ic leaf extracts

Cited by 5 publications

References 51 publications

Antimicrobial and mosquito larvicidal activity of iron oxide nanoparticles phytosynthesized from the medicinal plant Andrographis serpyllifolia

Antimicrobial and mosquito larvicidal activity of iron oxide nanoparticles phytosynthesized from the medicinal plant Andrographis serpyllifolia

Evaluation of in vivo Synergistic Hypoglycemic & Hypolipidemic Activity of Ethanolic Extract of Calotropis gigantean Leaves in Combination to Metformin in Alloxan Induced Rats

Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats

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