In vitro and in vivo tissue repair with laser‐activated chitosan adhesive

Lauto, Antonio; Stoodley, Marcus A.; Marcel, H. Tempelaars; Avolio, Alberto; Sarris, Maria; McKenzie, Gavin; Sampson, David D.; Foster, L. John R.

doi:10.1002/lsm.20418

Cited by 68 publications

(50 citation statements)

References 23 publications

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“…A novel chitosan-based adhesive film was coupled with a diode infrared laser (810 nm) to repair sheep intestine ex-vivo and rat sciatic nerves in vivo 78,79 (Fig. 2).…”

Section: Chitosan Adhesivesmentioning

confidence: 99%

Adhesive biomaterials for tissue reconstruction

Lauto

Mawad

Foster

2007

J of Chemical Tech & Biotech

124

102

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Tissue reconstruction and wound closure rely on sutures, staples and clips in current surgical procedures. These traditional devices are nonetheless unable to prevent leakage of fluids from a variety of tissue including blood vessels and dura mater. Furthermore, sutures are usually difficult to apply during minimal invasive surgery and often induce detrimental scarring that may impair healing. To overcome these disadvantages, biocompatible and biodegradable glues based on fibrin, polyethylene glycol (PEG) and cyanoacrylate have recently been used in patients to seal and repair tissue wounds. Cyanoacrylate glues create typically very strong tissue bonds but have mostly been applied externally for skin wound closure because of their residual cytotoxicity. Other adhesive biomaterials are also emerging; these glues and adhesives are usually based on proteins such as albumin and collagen or polysaccharides like chitosan; these are irradiated with coherent or non-coherent light to trigger their adhesion to tissue. These biomaterial based devices offer significant advantages over sutures, such as their sealing or repairing ability, easy application modality and delivery in situ of compounds for accelerating wound healing. This paper reviews different tissue reconstruction strategies employing adhesive biomaterials currently used in surgical and experimental procedures.

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“…A novel chitosan-based adhesive film was coupled with a diode infrared laser (810 nm) to repair sheep intestine ex-vivo and rat sciatic nerves in vivo 78,79 (Fig. 2).…”

Section: Chitosan Adhesivesmentioning

confidence: 99%

Adhesive biomaterials for tissue reconstruction

Lauto

Mawad

Foster

2007

J of Chemical Tech & Biotech

124

102

View full text Add to dashboard Cite

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“…Lauto et al investigated the adhesive ability of chitosan fi lm containing indocyanine green dye (IG) when activated with laser light [ 104,105 ] . As shown in Fig.…”

Section: Chitosan-based Sealantmentioning

confidence: 99%

Sealants (Adhesives) to Prevent Bleeding

Suzuki

Ikada

2011

Biomaterials for Surgical Operation

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In general, surgical sealants (adhesives) are liquids and form gels when applied. Currently, several products are clinically available, including naturally derived fi brin sealants, semisynthetic products such as gelatin and albumin-based glues, and synthetic products including cyanoacrylates and poly(ethylene glycol). These products, however, have both advantages and disadvantages. While fi brin sealants have been successfully used in many surgical fi elds, they have several disadvantages including low adhesive strength. Other products, such as cyanoacrylates and protein-based products, have high adhesion strength but have high toxicity, and therefore, their applications are limited. Studies are still ongoing in order to develop sealants with higher adhesion strength and safer properties compared to the sealants that are currently available. This chapter reviews the chemistry and applications of clinically available sealants and recent developments in this fi eld.

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“…The use of natural biopolymers for tissue repair has gained importance in the last few years [21,22]. In particular, polysaccharides as hyaluronan and chitosan and their derivatives are suitable candidates for laser welding mainly because of their high affinity for the biological matrix, biodegradability and low cost [23,24].…”

Section: Laser Welding With Biopolymeric Matrices and Gold Nanorodsmentioning

confidence: 99%

Gold nanorods as new nanochromophores for photothermal therapies

Ratto

Matteini

Centi

et al. 2010

Journal of Biophotonics

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Results and perspectives on the biomedical exploitation of gold nanorods with plasmon resonances in the near infrared window are reported. The authors describe experimental studies of laser-activated nanoparticles in the direct welding of connective tissues, which may become a valuable technology in biomedicine. In particular, colloidal gold nanorods excited by diode laser radiation at 810 nm were used to mediate functional photothermal effects and weld eye's lens capsules and arteries. The preparation of biopolymeric matrices including gold nanorods is also described, as well as preliminary tests for their application in the closure of wounds in vessels and tendons. Finally, the use of these nanoparticles for future applications in the diagnosis, imaging and therapy of cancer is discussed.

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In vitro and in vivo tissue repair with laser‐activated chitosan adhesive

Cited by 68 publications

References 23 publications

Adhesive biomaterials for tissue reconstruction

Adhesive biomaterials for tissue reconstruction

Sealants (Adhesives) to Prevent Bleeding

Gold nanorods as new nanochromophores for photothermal therapies

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