In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles

Baksi, Ruma; Singh, Devendra P.; Borse, Swapnil; Rana, Rita; Sharma, Vipin; Nivsarkar, Manish

doi:10.1016/j.biopha.2018.07.106

Cited by 138 publications

(71 citation statements)

References 89 publications

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“…They also possess various human health‐promoting activities (e.g. antioxidant, anti‐inflammatory, anti‐angiogenic, anti‐proliferative, antifungal, antibacterial), and protective effects against neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases (O'Leary et al ., ; Santos et al ., ; Gechev et al ., ; Baksi et al ., ). The large diversity of chemical structures of (iso)flavonoids contribute to their multiple bioactivity.…”

Section: Introductionmentioning

confidence: 97%

Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP‐β‐l‐rhamnose and rhamnosylation mechanism

et al. 2019

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Glycosylation is a key modification for most molecules including plant natural products, for example, flavonoids and isoflavonoids, and can enhance the bioactivity and bioavailability of the natural products. The crystal structure of plant rhamnosyltransferase UGT89C1 from Arabidopsis thaliana was determined, and the structures of UGT89C1 in complexes with UDP-b-L-rhamnose and acceptor quercetin revealed the detailed interactions between the enzyme and its substrates. Structural and mutational analysis indicated that Asp356, His357, Pro147 and Ile148 are key residues for sugar donor recognition and specificity for UDPb-L-rhamnose. The mutant H357Q exhibited activity with both UDP-b-L-rhamnose and UDP-glucose. Structural comparison and mutagenesis confirmed that His21 is a key residue as the catalytic base and the only catalytic residue involved in catalysis independently as UGT89C1 lacks the other catalytic Asp that is highly conserved in other reported UGTs and forms a hydrogen bond with the catalytic base His. Ser124 is located in the corresponding position of the catalytic Asp in other UGTs and is not able to form a hydrogen bond with His21. Mutagenesis further showed that Ser124 may not be important in its catalysis, suggesting that His21 and acceptor may form an acceptor-His dyad and UGT89C1 utilizes a catalytic dyad in catalysis instead of catalytic triad. The information of structure and mutagenesis provides structural insights into rhamnosyltransferase substrate specificity and rhamnosylation mechanism.

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Section: Introductionmentioning

confidence: 97%

Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP‐β‐l‐rhamnose and rhamnosylation mechanism

et al. 2019

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“…Treatments for the disease include radio-and chemo-therapy, surgery, and targeted immunotherapy [2]. However, current cytotoxic drugs present several limitations, including poor affordability and/or availability (especially in developing countries), and toxic effects on non-targeted tissues [2,3]. Adverse side-effects of cytotoxic drugs include vomiting, stomatitis, alopecia, cardiomyopathy, leucopoenia, peripheral neuropathy and even secondary malignancy [3].…”

Section: Introductionmentioning

confidence: 99%

“…However, current cytotoxic drugs present several limitations, including poor affordability and/or availability (especially in developing countries), and toxic effects on non-targeted tissues [2,3]. Adverse side-effects of cytotoxic drugs include vomiting, stomatitis, alopecia, cardiomyopathy, leucopoenia, peripheral neuropathy and even secondary malignancy [3]. In addition, tumor cells may develop resistance to a wide variety of chemotherapeutic drugs or their combinations, which is known as multidrug resistance (MDR) [3,4] and represents the main factor in the failure of many forms of chemotherapy regimens.…”

Section: Introductionmentioning

confidence: 99%

“…Adverse side-effects of cytotoxic drugs include vomiting, stomatitis, alopecia, cardiomyopathy, leucopoenia, peripheral neuropathy and even secondary malignancy [3]. In addition, tumor cells may develop resistance to a wide variety of chemotherapeutic drugs or their combinations, which is known as multidrug resistance (MDR) [3,4] and represents the main factor in the failure of many forms of chemotherapy regimens. MDR is caused by several mechanism such increased drug efflux, decreased drug uptake, evasion of drug-induced apoptosis, activation of DNA repair mechanisms or activation of detoxifying systems [5].…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, much attention is currently being paid to naturally occurring bioactive compounds, specially phytochemicals, which are plants secondary metabolites that can be found in seeds, fruits, vegetables, red wine, tea and olive oil [2,6] and for which certain anticarcinogenic properties have been identified [2,3,6,7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Berries polyphenols: Nano-delivery systems to improve their potential in cancer therapy

Forbes‐Hernández

2020

JBR

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Berries bioactive compounds, specially polyphenols, have been widely recognized for their chemopreventive and chemotherapeutic properties. However, most of them struggle with chemical instability, low solubility, extensive metabolism and consequently poor bioavailability, which limit their clinical use. An effective strategy to overcome such problems consists of the nano-delivery systems. In the present review, the progress made in utilization of nano-carriers for berries polyphenols administration either alone or in combination with chemotherapeutic drugs have been summarized.

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Flavonoids as Nutraceuticals

Adangale

Ghosh

Wairkar

2022

Handbook of Nutraceuticals and Natural Products

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In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles

Cited by 138 publications

References 89 publications

Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP‐β‐l‐rhamnose and rhamnosylation mechanism

Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP‐β‐l‐rhamnose and rhamnosylation mechanism

Berries polyphenols: Nano-delivery systems to improve their potential in cancer therapy

Flavonoids as Nutraceuticals

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