2006
DOI: 10.1148/radiol.2403051341
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In Vitro and in Vivo Imaging Studies of a New Endohedral Metallofullerene Nanoparticle

Abstract: The new functionalized trimetallic nitride endohedral metallofullerene species Gd(3)N@C(80)[DiPEG5000(OH)(x)] is an effective proton relaxation agent, as demonstrated with in vitro relaxivity and MR imaging studies, in infusion experiments with agarose gel and in vivo rat brain studies simulating clinical conditions of direct intraparenchymal drug delivery for the treatment of brain tumors.

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Cited by 198 publications
(210 citation statements)
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“…Sc x Gd 3−x N@C 80 O m (OH) n (where x = 1, 2; m ≈ 12; n ≈ 26), respectively, gave r 1 values of 20.7 and 17.6 mM −1 s −1 . This is an important result as Sc x Gd 3−x N@C 80 was synthesised in greater yields than both Gd@C 82 and Gd 3 N@C 80 , and was actually the third most abundant fraction from the arc discharge soot, after C 60 and C 70 .…”
Section: Magnetic Resonance Imagingmentioning
confidence: 86%
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“…Sc x Gd 3−x N@C 80 O m (OH) n (where x = 1, 2; m ≈ 12; n ≈ 26), respectively, gave r 1 values of 20.7 and 17.6 mM −1 s −1 . This is an important result as Sc x Gd 3−x N@C 80 was synthesised in greater yields than both Gd@C 82 and Gd 3 N@C 80 , and was actually the third most abundant fraction from the arc discharge soot, after C 60 and C 70 .…”
Section: Magnetic Resonance Imagingmentioning
confidence: 86%
“…Their synthesis was vastly improved by Dunsch et al 52 whose 'reactive gas atmosphere' concept -the addition of ammonia into the reactor -gave EMFs as the majority fullerene product for the first time. The composition of the TNT EMFs can be generalised to X x Y y M 3−x−y N@C 80 , where X, Yand M are different metallic species. These species exist because the nitride clusters have been found to stabilise the highsymmetry I h -C 80 cage.…”
Section: Endohedral Metallofullerenesmentioning
confidence: 99%
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“…Excitation of fullerenes placed in a biological medium by external radiation or incident heavy ions may lead to the generation of secondary electrons or reactive oxygen species which allows fullerenes to be potentially used as sensitizers in photodynamic therapy [18] and ion beam cancer therapy [19]. The possible medicinal applications of endohedral fullerenes include, for instance, their use in radio-immunotherapy for a stable encapsulation of radionuclides [20] and in radiology for enhancing imaging techniques [21,22].…”
Section: Atomic Cluster Sciencementioning
confidence: 99%