In vitro and in vivo evaluation of alginate and alginatechitosan beads containing metformin hydrochloride

Mokhtare, Behzad; Çetin, Meltem; Özakar, Rukiye Sevinç; Bayrakçeken, Hatice

doi:10.4314/tjpr.v16i2.5

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…hydrochloride, chemically N,Ndimethylimidodicarbionimidic diamide hydrochloride (1,1diamethylbiguanide hydrochloride), belongs to the 'biguanide' class as shown in Figure 1 3,4 . After oral administration, metformin is mainly absorbed from the upper small intestine, and it undergoes limited systemic absorption (absolute bioavailability is about 50 to 60 %) with a half-life of about 3 h. Therefore, repeated administration of the conventional metformin hydrochloride tablets is needed for effective treatment [4][5][6] . 7 .…”

Section: Metforminmentioning

confidence: 99%

“…Metformin hydrochloride reference standard solution was prepared in different concentrations (3,4,5,6, and 7 µg/ml) using phosphate buffer (pH = 6.8) medium. Their absorbances were measured at  max of 233 nm using a UV-Visible spectrophotometer (Double beam UV-Visible Spectrophotometer, T92+, PG instrument limited).…”

Section: Construction Of Calibration Curve For Metformin Hydrochloridementioning

confidence: 99%

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Comparative In Vitro Evaluation Of Different Brands Of Metformin Hydrochloride Film Coated Tablets Marketed In Addis Ababa, Ethiopia

Abatea

Temesgen

Nigatu

2020

Asian J Pharm Res Dev

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Metformin hydrochloride is a biguanide class of drug widely used to treat Type 2 diabetes mellitus. Its oral bioavailability is about 50 to 60 % with a half-life of about 3 h. This study focused on evaluation and comparison of the physicochemical properties of different brands of metformin hydrochloride (500mg) film coated tablets available in drug retail outlets in Addis Ababa, Ethiopia. Some different in vitro tests including hardness, weight variation, disintegration time, dissolution study, and assay were conducted as per United States Pharmacopeia. To compare dissolution profiles of the generic products against the innovator product (product A), a model independent method, similarity factor (f2), was also used. Weight variation result showed that all brand fall within the 5% limit from the average which is acceptable. Disintegration time of less than 15 minutes was observed for all brands. The in vitro drug release study results for the products ranged between 82 and 93% release within 30 minutes which is above 80% limit as per the United States Pharmacopeia requirement. The similarity f2 values for generic products ranged from 53 to 75%. Furthermore, assay value of the studied brands varied from 95.60 to 104.37% which was within standard limit (95-105%). It can be concluded that all brands of metformin hydrochloride tablets met pharmacopoeial specification for the tested parameters of physicochemical properties like weight variation, hardness of tablets, disintegration time, drug release study and assay.

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Section: Metforminmentioning

confidence: 99%

Section: Construction Of Calibration Curve For Metformin Hydrochloridementioning

confidence: 99%

Comparative In Vitro Evaluation Of Different Brands Of Metformin Hydrochloride Film Coated Tablets Marketed In Addis Ababa, Ethiopia

Abatea

Temesgen

Nigatu

2020

Asian J Pharm Res Dev

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“…The unsatisfactory oral absorption efficiency and short half-life of MET lead to frequent dosage administration with high dose, even gram levels one day (Wang et al 2017;Shurrab and Arafa 2020). Therefore, great efforts have been made to improve this situation, and several nano-DDS loaded with MET were rationally designed to obtain controlled drug release and improved oral absorption, including alginate NPs (Kumar et al 2017), alginatechitosan NPs (Mokhtare et al 2017), hyaluronic acid NPs (Bhujbal and Dash 2018) and chitosan/ eudragit nanocomplex (Sahu and Verma 2016). For instance, MET-loaded alginate NPs were developed by an emulsion cross-linking technology for diabetes treatment (Kumar et al 2017).…”

Section: Met-encapsulated Nano-dds For Oral Deliverymentioning

confidence: 99%

Emerging nanoparticulate drug delivery systems of metformin

Chen

Shan

Luo

et al. 2020

J. Pharm. Investig.

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Background Driving the conventional drug in new applications has emerged as a research hotspot for disease treatment. Metformin (MET) is conventionally used for the treatment of type II diabetes. It has also been found to be a versatile molecule with wide biological functions, such as losing weight. anti-aging and anticancer activity. Rational design of nanoparticulate drug delivery systems (nano-DDS) could significantly improve drug delivery efficiency. Recently, a wide range of nano-DDS has been developed to improve the delivery efficacy of MET or to perform as versatile nanoplatforms for efficient drug delivery. Area covered In this review, we outline the emerging trends in advanced nano-DDS of MET, focusing on nano-DDS of MET for diabetes therapy, nano-DDS of MET for anticancer therapeutics, and nano-DDS of MET for other therapeutic aims. Expert opinion Despite the great progression in nano-DDS of MET, there's still a long way to truly put the conventional drug in new applications. Several important issues should be fully taken into consideration, such the manufacturing cost and economic burdens for patients, the biocompatibility and long-term toxicity of carrier materials, scale-up preparation difficulties, as well as the species gap between human beings and animal models.

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“…For methylprednisolone release, non-Fickian diffusion processes were found under either PEIÀ C60 or PEI species incorporation. [23] Several nano drug delivery systems loaded with metformin were planned to acquire controlled drug release and enhanced oral absorption, such as alginate NPs, [24] alginate chitosan NPs, [25] hyaluronic acid NPs [26] and chitosan/eudragit nanocomplex. [27] Metformin-loaded alginate NPs were advanced through an emulsion cross-linking method for diabetes treatment.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release Study of Metformin Using Trithiocyanuric Acid Functionalized MCM‐41 as a Nanocarrier

Hajiaghababaei,

Gholinejad Keshteli,

Badiei

et al. 2023

ChemistrySelect

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Ordered nanoporous silica such as MCM‐41 has silanol groups that can be chemically modified to effectively control the release of molecules. In this regard, MCM‐41 was functionalized with trithiocyanuric acid groups (TTCA‐MCM‐41) and offered as a novel carrier to the controlled release of metformin. TTCA‐MCM‐41 was synthesized and characterized. Thereafter, for 3 hours, saturated metformin solution was contacted with TTCA‐MCM‐41 to loading of drug. Finally, drug release profile was investigated in simulated body fluid (SBF) and phosphate buffers. The hexagonal symmetry of the TTCA‐MCM‐41 was confirmed by XRD patterns. The BET surface area, centred on N2 adsorption‐desorption, dropped from 846.5 m2/g for the MCM‐41 to 295.2 m2/g for the TTCA‐MCM‐41. With the use of FT‐IR spectra, the presence of TTCA groups in the silica system was established. The rope‐shaped morphology and the existence of S and N atoms on the MCM‐41 are visible in the SEM and EDX. The metformin release from TTCA‐MCM‐41 exhibits a pH‐based behaviour, and release rate was faster at higher pH compared to lower pH in phosphate buffers. In SBF, metformin displayed a steady release rate of around 0.2 mg min−1. The findings demonstrated that TTCA‐MCM‐41 is a promising candidate as a novel metformin carrier.

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In vitro and in vivo evaluation of alginate and alginatechitosan beads containing metformin hydrochloride

Abstract: Purpose: To prepare metformin HCl-loaded alginate (AL) and alginate-chitosan (AL-CS) beads for oral application and to evaluate their in vitro characteristics

Cited by 12 publications

References 22 publications

Comparative In Vitro Evaluation Of Different Brands Of Metformin Hydrochloride Film Coated Tablets Marketed In Addis Ababa, Ethiopia

Comparative In Vitro Evaluation Of Different Brands Of Metformin Hydrochloride Film Coated Tablets Marketed In Addis Ababa, Ethiopia

Emerging nanoparticulate drug delivery systems of metformin

Controlled Release Study of Metformin Using Trithiocyanuric Acid Functionalized MCM‐41 as a Nanocarrier

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