In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy

β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

“…This all leads toward relaxation of macromolecules and increased swelling dynamics of developed hydrogels. Additionally, the carboxylate anions induce more hydrophilicity in the polymeric network thus contributing to enhanced swelling ratio of hydrogels (You et al, 2015).…”

Colon-targeting mutual prodrugs of 5-aminosalicylic acid and butyrate for the treatment of ulcerative colitis

“…Colitis was induced according to the previous study. 18,19 Briefly, after 12 h of fasting, mice were anesthetized with intraperitoneal pentobarbital sodium (35 mg kg −1 ) before the induction of colitis. 0.1 mL of 50% (v/v) ethanol contained 2.5% (v/v) TNBS was instilled into the colon 3.5–4 cm from the anus by a gavage needle.…”

Food Gum based Hydrogel Polymers

“…Pectin based hydrogels: Pectin is an anionic polysaccharide hydrogel, poly (1,4-galacturonic acid), found in the cell walls of terrestrial plants, which has been traditionally used in food industry. 30 Recently, it has also become a material of interest from the biomedical point of view. Tripathi et al 31 fabricated chitosan/poly (vinyl alcohol)/pectin ternary films and showed that the films have excellent antimicrobial properties for food packaging applications.…”