In vitro and in vivo combined antibacterial effect of levofloxacin/silver co-loaded electrospun fibrous membranes

Song, Ziliang; Ma, Yan; Xia, Guanggai; Kapadia, Wasim; Sun, Zhiyong; Wu, Wei; Gu, Hongchen; Cui, Wenguo; Huang, Xinyu

doi:10.1039/c7tb01243h

Cited by 21 publications

(14 citation statements)

References 39 publications

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“…Then the absorbance of the supernatant was measured using ultraviolet-visible spectrophotometer at 357 nm and 287 nm for TC and LEV, respectively. [7][8][9][10] To facilitate description, the adsorbed samples would be represented by abbreviations. For example, IP-LEV is the IP sample aer LEV adsorption.…”

Section: Adsorption Experimentsmentioning

confidence: 99%

Antibiotic removal by agricultural waste biochars with different forms of iron oxide

Chen

Shi

et al. 2019

RSC Adv.

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Section: Adsorption Experimentsmentioning

confidence: 99%

Antibiotic removal by agricultural waste biochars with different forms of iron oxide

Chen

Shi

et al. 2019

RSC Adv.

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“…Another study of combined antimicrobial strategies showed that the main body of a laminar mesh of ePTFE with a coating of silver carbonate and chlorhexidine diacetate remained clean but thick fibrous encapsulation, seroma and purulent material were observed related to the mesh anchorage (see Figure 6) [221]. In the same research line, a mesoporous silica nanoplatform (MSN) composed of levofloxacin (Lev) and silver (Lev@MSN@Ag), and poly-L-lactide (PLLA) electrospun (Lev@MSN@Ag-PLLA) via blending electrospinning was proposed as an alternative antimicrobial option for hernia repair (see Figure 8) [256]. The combined action of these compounds allows high inhibition of resistant bacteria without the need for applying high doses of antibiotics, which can be toxic for the human body.…”

Section: Meshes Produced By Combined Strategiesmentioning

confidence: 95%

“…Images indicating the wound healing status and scar formation. (a) control, (b) PP, (c) PLLA, (d) MSN@Ag-PLLA, (e) Lev@MSN-PLLA, (f) Lev@MSN@Ag-PLLA -Published by The Royal Society of Chemistry (RSC)[256].…”

mentioning

confidence: 99%

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Serrano‐Aroca¹,

Pous‐Serrano²

2021

Preprint

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Worldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons working in this area classified according to their biological or chemical nature, morphology and whether bioabsorbable or not. We emphasise the importance of surgical site infection in herniatology, how to deal with this microbial problem, and we go further into the future research lines on the production of advanced antimicrobial meshes to improve hernia repair and prevent microbial infections, including multidrug-resistant strains. A great deal of progress has been made in this biomedical field in the last decade. However, we are still far from an ideal antimicrobial mesh that can also provide excellent integration to the abdominal wall, mechanical performance, low visceral adhesion and minimal inflammatory or foreign body reactions, among many other problems.

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“…Levofloxacin/silver coloaded electrospun fibrous membranes were prepared by Huang and co‐workers and their in vivo and in vitro antibacterial effects tested . In a first step, the authors prepared AgNPs coated with a MS layer and loaded the pores with levofloxacin.…”

Section: Ms In Antibacterial Applicationsmentioning

confidence: 99%

Mesoporous Silica‐Based Materials with Bactericidal Properties

Bernardos

Piacenza

Sancenón

et al. 2019

Small

145

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Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.

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In vitro and in vivo combined antibacterial effect of levofloxacin/silver co-loaded electrospun fibrous membranes

Abstract: The Lev@MSN@Ag–PLLA fibers provided an advanced synergistic antibacterial nanoplatform of low dosage for the treatment of drug-resistant bacterial infections.

Cited by 21 publications

References 39 publications

Antibiotic removal by agricultural waste biochars with different forms of iron oxide

Antibiotic removal by agricultural waste biochars with different forms of iron oxide

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Mesoporous Silica‐Based Materials with Bactericidal Properties

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