In Vitro and In Vivo Evaluation of Guar Gum-Based Matrix Tablets of Rofecoxib for Colonic Drug Delivery

Al-Saidan, Saleh M.; Krishnaiah, Y. S. R.; Satyanarayana, V.; Rao, G. Subba

doi:10.2174/1567201053586010

Cited by 38 publications

(10 citation statements)

References 32 publications

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“…This slow release also makes slow absorption of the drug and making it available for local action in human colon. [128] Polysaccharide based hydrogels are also prepared to achieve antitumoral drug relesase.…”

Section: Use Of Gum In Development Of Drug Deliverymentioning

confidence: 99%

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Upadhyay

2017

IJGP

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The present review explains nutritional, therapeutic, and pharmaceutical potential of plant gum that is commonly applied to water-soluble, non-starch polysaccharides of commerce. This article also emphasizes commercial and domestic uses of important products of gum such as chicle and jelutong mainly non-elastic gums or chewing gums. These are also used in food, pharmaceutical, paper textile, and other industries. The present review also explains various biological activities such as antidiarrheic, antitumor, anti-inflammatory, anti-arthritic, antiparasitic, gastrourinary, antitumor, antiparasitic, antioxidant, chemopreventive, and gastroprotective activity of plant gums. These reduce stomach inflammation, system cleansing or to settle the intestines. Other uses for mesquite gum include treatment for lice, sore throat, cough, laryngitis, fever reduction, painful gums, and hemorrhoids and it can be used as a purgative. Gum arabic is a water-soluble dietary fiber rich in Ca , and decreases plasma phosphate concentration as well as urinary excretion of phosphate and Na + . Gums are used as adhesives, crystallization inhibitors, emulsifying agents, emulsion stabilizers, encapsulating agents, film formers, foam stabilizers, suspending agents, suspension stabilizers, or syneresis inhibitors and impart other specific properties. The gum is also used to a limited extent in polishes, contact insecticides and pesticides, photographic emulsions, and pharmaceuticals. This article suggests wider use of plant gums in generation of drug delivery system for cancer and brain tumor therapy. There is no doubt that chemical constituents of plant gums can be largely used for making therapeutic drugs because of their broadspectrum biological effectiveness.

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Section: Use Of Gum In Development Of Drug Deliverymentioning

confidence: 99%

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Upadhyay

2017

IJGP

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“…Guar gum-based matrix tablets of rofecoxib for their intended use in the chemoprevention of colorectal cancer were developed and evaluated [116]. Matrix tablets containing 40% (RXL-40), 50% (RXL-50), 60% (RXL-60) or 70% (RXL-70) of guar gum were prepared by wet granulation technique.…”

Section: Delayed Onset For Targeting Colon Drug Deliverymentioning

confidence: 99%

Targeting Colon Drug Delivery by Natural Products

Kim¹

2012

Inflammatory Bowel Disease

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“…In vivo studies showed delayed T max , prolonged absorption time and decreased C max indicating that rofecoxib was not released significantly in stomach and small intestine, but was delivered to colon resulting in a slow absorption of the drug and making it available for local action in human colon22.…”

Section: Gumsmentioning

confidence: 99%

Herbal excipients in novel drug delivery systems

Shirwaikar¹,

Prabu²,

Kumar³

2008

Indian J Pharm Sci

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The use of natural excipients to deliver the bioactive agents has been hampered by the synthetic materials. However advantages offered by these natural excipients are their being non-toxic, less expensive and freely available. The performance of the excipients partly determines the quality of the medicines. The traditional concept of the excipients as any component other than the active substance has undergone a substantial evolution from an inert and cheap vehicle to an essential constituent of the formulation. Excipients are any component other than the active substance(s) intentionally added to formulation of a dosage form. This article gives an overview of herbal excipients which are used in conventional dosage forms as well as novel drug delivery systems.

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In Vitro and In Vivo Evaluation of Guar Gum-Based Matrix Tablets of Rofecoxib for Colonic Drug Delivery

Cited by 38 publications

References 32 publications

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Targeting Colon Drug Delivery by Natural Products

Herbal excipients in novel drug delivery systems

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