In vitro and in vivo photodynamic efficacies of novel and conventional phenothiazinium photosensitizers against multidrug-resistant Candida auris

Barião, Patrícia Helena Grizante; Tonani, Ludmilla; Brancini, Guilherme Thomaz Pereira; Nascimento, Érika; Braga, Gilberto Úbida Leite; Wainwright, Mark S.; Kress, Márcia Regina von Zeska

doi:10.1007/s43630-022-00258-4

Cited by 11 publications

(6 citation statements)

References 48 publications

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“…Their efficacy was evaluated using MIC and the G. mellonella insect model. Based on the findings, the pentacyclic derivative S137 was identified as a potent treatment for C. auris [108]. Previously, it had demonstrated strong inhibition of C. albicans [109].…”

Section: Photosensitizers Based Antimicrobial Photodynamic Therapy (A...mentioning

confidence: 99%

Current Perspectives of Antifungal Therapy: A Special Focus on <em>Candida auris</em>

Arumugam,

Muthuselvam,

Lima

et al. 2024

Preprint

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Candida auris is considered an emerging Candida species that has rapidly spread all over the world. The evidence of its origin and emerging resistance is still unclear. The severe infection by this species causes significant mortality and morbidity among the elderly and immune compressed individuals. Development of drug resistance is the major factor associated with therapeutic failure of existing antifungal agents. Previous studies addressed the antifungal resistance profile and drug discovery for C. auris. However, comprehensive coverage of these information in a single investigation yet to be available. In this review, we have mainly focused on recent development in therapeutic strategy against C. auris. Based on the available information, several differential approaches were discussed, including existing antifungal drugs, chemical compounds, essential oils, natural products, antifungal peptides, immunotherapy, antimicrobial photodynamic therapy, drug repurposing, and drug delivery systems. Among them, chemical medications, natural products, and antifungal peptides are the prime contributors. However, a limited number of resources are available to prove the efficiency of these potential therapies in clinical usage. Hence, we hope that the data gathered in this review can encourage in vivo studies and clinical trials.

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Section: Photosensitizers Based Antimicrobial Photodynamic Therapy (A...mentioning

confidence: 99%

Current Perspectives of Antifungal Therapy: A Special Focus on <em>Candida auris</em>

Arumugam,

Muthuselvam,

Lima

et al. 2024

Preprint

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“…Their efficacy was evaluated by the determination of MIC and the use of a G. mellonella insect model. Based on the findings, the pentacyclic derivative S137 was identified as a potent treatment for C. auris [ 115 ]. Previously, it had demonstrated strong inhibition of C. albicans [ 116 ].…”

Section: Therapeutic Optionsmentioning

confidence: 99%

Current Perspectives of Antifungal Therapy: A Special Focus on Candida auris

Ganeshkumar,

Muthuselvam,

Lima

et al. 2024

JoF

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Candida auris is an emerging Candida sp. that has rapidly spread all over the world. The evidence regarding its origin and emerging resistance is still unclear. The severe infection caused by this species results in significant mortality and morbidity among the elderly and immunocompromised individuals. The development of drug resistance is the major factor associated with the therapeutic failure of existing antifungal agents. Previous studies have addressed the antifungal resistance profile and drug discovery for C. auris. However, complete coverage of this information in a single investigation is not yet available. In this review, we have mainly focused on recent developments in therapeutic strategies against C. auris. Based on the available information, several different approaches were discussed, including existing antifungal drugs, chemical compounds, essential oils, natural products, antifungal peptides, immunotherapy, antimicrobial photodynamic therapy, drug repurposing, and drug delivery systems. Among them, synthetic chemicals, natural products, and antifungal peptides are the prime contributors. However, a limited number of resources are available to prove the efficiency of these potential therapies in clinical usage. Therefore, we anticipate that the findings gathered in this review will encourage further in vivo studies and clinical trials.

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“…Phenothiazinium dyes are the most common PSs used in PDT performed on the G. mellonella model [ 58 , 210 , 212 , 216 , 222 ]. During the administration of the desired PS into the larva´s hemocoel, the body of the larva becomes colored, which is an accompanying phenomenon.…”

Section: Principles Of Apdt and The Use Of G Mellonella ...mentioning

confidence: 99%

“…The source of light is a light-emitting diode (LED light) or diode laser. The irradiation itself must not affect the survival of the larvae [ 18 , 58 , 212 , 222 , 223 , 230 , 231 ].…”

Section: Principles Of Apdt and The Use Of G Mellonella ...mentioning

confidence: 99%

Galleria mellonella—A Model for the Study of aPDT—Prospects and Drawbacks

Bugyna,

Kendra,

Bujdáková

2023

Microorganisms

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Galleria mellonella is a promising in vivo model insect used for microbiological, medical, and pharmacological research. It provides a platform for testing the biocompatibility of various compounds and the kinetics of survival after an infection followed by subsequent treatment, and for the evaluation of various parameters during treatment, including the host–pathogen interaction. There are some similarities in the development of pathologies with mammals. However, a limitation is the lack of adaptive immune response. Antimicrobial photodynamic therapy (aPDT) is an alternative approach for combating microbial infections, including biofilm-associated ones. aPDT is effective against Gram-positive and Gram-negative bacteria, viruses, fungi, and parasites, regardless of whether they are resistant to conventional treatment. The main idea of this comprehensive review was to collect information on the use of G. mellonella in aPDT. It provides a collection of references published in the last 10 years from this area of research, complemented by some practical experiences of the authors of this review. Additionally, the review summarizes in brief information on the G. mellonella model, its advantages and methods used in the processing of material from these larvae, as well as basic knowledge of the principles of aPDT.

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In vitro and in vivo photodynamic efficacies of novel and conventional phenothiazinium photosensitizers against multidrug-resistant Candida auris

Cited by 11 publications

References 48 publications

Current Perspectives of Antifungal Therapy: A Special Focus on <em>Candida auris</em>

Current Perspectives of Antifungal Therapy: A Special Focus on <em>Candida auris</em>

Current Perspectives of Antifungal Therapy: A Special Focus on Candida auris

Galleria mellonella—A Model for the Study of aPDT—Prospects and Drawbacks

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