In vitro and in vivo evaluation of a new sublingual tablet system for rapid oromucosal absorption using fentanyl citrate as the active substance

Bredenberg, Susanne; Duberg, M.; Lennernäs, Bo; Lennernäs, Hans; Pettersson, Anders; Westerberg, Marcus; Nyström, Christer

doi:10.1016/j.ejps.2003.07.002

Cited by 100 publications

(54 citation statements)

References 28 publications

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“…Granulated mannitol was used as a carrier molecule and crosslinked polyvinyl pyrrolidone was used as disintegrant and bioadhesive material. The formulation containing 100 and 200 microgram of fentanyl citrate had a dissolution rate of 80% within 1 minute and more than 95% within 5 minutes [41]. …”

Section: Literature Reviewmentioning

confidence: 99%

Mouth dissolving tablets- A unique dosage form curtailed for special purpose: a review

Nasreen¹

2013

IOSR-JPBS

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Section: Literature Reviewmentioning

confidence: 99%

Mouth dissolving tablets- A unique dosage form curtailed for special purpose: a review

Nasreen¹

2013

IOSR-JPBS

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“…25) Hydrophobic polymer mats can be used for the formulation with controlled release applications where prolonged action is required for the treatment of chronic diseases.…”

Section: )mentioning

confidence: 99%

Single and Multi-Layered Nanofibers for Rapid and Controlled Drug Delivery

Azarbayjani

Chan

2010

Chem. Pharm. Bull.

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143Polymeric drug delivery systems are able to improve therapeutic efficacy, reduce toxicity, and can be designed to control and prolong drug release by adjusting the degradation rate of the polymer.1,2) Poly vinyl alcohol (PVA) is a biodegradable, hydrophilic polymer with distinct properties such as high degree of swelling, inherent non-toxicity and good biocompatibility. 3,4) Aliphatic polyesters such as poly (D,L-lactide) (PLA) and its copolymers with glycolic acid (PLGA) are biodegradable and biocompatible polymers with remarkably broad applications in sustained drug delivery. 5-7)Cyclodextrins (CDs) are a group of cyclic oligosaccharides. They are able to form inclusion complexes with lipophilic guest molecules which have been shown to improve aqueous solubility, dissolution rate and bioavailability of lipophilic drugs without decreasing the intrinsic ability of the lipophilic drug molecule to penetrate the biological membranes. Modified CDs, such as randomly methylated b-cyclodextrin (RM b-CD) have gained increasing popularity due to its improved water solubility and less toxicity as compared with the natural b-cyclodextrin. 8-10)One of the approaches for modulating the release of drugs from a delivery system and changing the release kinetics over a period of time is to use blends of hydrophilic and hydrophobic polymers. 11)Electrospinning utilizes high voltage source to produce nanoscale and microscale polymeric fibers with high surface area-to-volume ratio and porosity. 1,12,13) When the electrostatic charge exceeds the surface tension of the solution, the fiber jet travels from the syringe nozzle to the electrically charged ground collector and allows the solvent to evaporate, thus leading to the deposition of the non-woven solid polymer fiber on the surface of the metallic target collector. Multi-layered nanofiber mat is obtained by sequentially electrospinning the second polymer solution on the same target collector as the first polymer. This strategy helps to compensate the limitation of the individual polymers while the inherent advantage of both the polymers can be obtained in a single fiber mat. [14][15][16][17] The aim of this work is the preparation of haloperidol loaded nanofiber via electrospinning of hydrophobic, PLA and PLGA, and hydrophilic polymers, PVA and RM b-CD. We intend to demonstrate that multi-component/multilayered polymeric mixture influence the physical and biological properties of electrospun fibers. The nanofiber morphology, structure, diameter of the polymeric nanofiber mats were investigated by field emission scanning electron microscopy (FESEM), and fourier transform infrared (FT-IR) measurements. The release characteristics of haloperidol from the drug-loaded fiber mats were investigated. ExperimentalMaterials PLA (R 203H with inherent viscosity of 0.34 dl/g), PLGA (73 : 27 and 48 : 52) RG 503, RG 755S with inherent viscosity of 0.63 dl/g and 0.52 dl/g were a kind gift from Boehringer Ingelheim (Ingelheim, Germany). PVA Mw 70000-100000 and haloperidol were purchased from S...

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“…Oral mucosal delivery, especially that utilizing the sublingual mucosa as an absorption site, is a promising drug delivery route which promotes rapid absorption and high bioavailability, with a subsequent, almost immediate onset of pharmacological effect (8). These advantages are the result of the highly vascularized oral mucosa, through which drugs enter the systemic circulation directly, by-passing the gastrointestinal tract and first pass metabolism in the liver (9).…”

Section: Introductionmentioning

confidence: 99%

Development of a GC-MS Assay for the Determination of Fentanyl Pharmacokinetics in Rabbit Plasma after Sublingual Spray Delivery

Malkawi

Al-Ghananeem

Crooks

2008

AAPS J

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In vitro and in vivo evaluation of a new sublingual tablet system for rapid oromucosal absorption using fentanyl citrate as the active substance

Cited by 100 publications

References 28 publications

Mouth dissolving tablets- A unique dosage form curtailed for special purpose: a review

Mouth dissolving tablets- A unique dosage form curtailed for special purpose: a review

Single and Multi-Layered Nanofibers for Rapid and Controlled Drug Delivery

Development of a GC-MS Assay for the Determination of Fentanyl Pharmacokinetics in Rabbit Plasma after Sublingual Spray Delivery

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