In vitro and in vivo safety studies of cinnamon extract ( Cinnamomum cassia ) on general and genetic toxicology

Yun, Jun Won; You, Ji Ran; Kim, Yun Soon; Kim, Seung Hyun; Cho, Eun Young; Yoon, Jung Hee; Kwon, Euna; Jang, Ja June; Park, Jin-Sung; Kim, Hyoung Chin; Hwan, Jeong; Kang, Byeong Cheol

doi:10.1016/j.yrtph.2018.02.017

Cited by 44 publications

(28 citation statements)

References 47 publications

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“…As pointed by Memar et al [ 23 ], knowing the mechanism of action of the essential oils is one thing, but to achieve a clinical use, the research of the toxicity should not be forgotten. E-cinnamaldehyde is known to present toxicity against cancer cell lines but also against normal cell lines, as observed in the present study [ 25 , 26 ]. As mentioned before, the results regarding Chinese cinnamon should be carefully interpreted.…”

Section: Discussionsupporting

confidence: 58%

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

et al. 2020

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There is a huge concern in the medical field concerning the emergence of bacterial resistance to antibiotics. Essential oils are a source of antibacterial compounds that can overcome this problem. Ten essential oils that are commercially available were investigated in the present study: ajowan, basil, German chamomile, Chinese cinnamon, coriander, clove, lemongrass, Spanish lavender, oregano and palmarosa. Their direct, synergistic and indirect antibacterial activities were evaluated against different human pathogenic Gram-positive and Gram-negative strains. To evaluate their possible use in clinics, the cytotoxicity of these essential oils was also tested on keratinocyte and epithelial cell lines. Except for the Chinese cinnamon, coriander and lemongrass, all other essential oils presented no cytotoxicity at 32 and 16 μg/mL. The highest indirect antibacterial activities were observed with the palmarosa and Spanish lavender in association with penicillin V. These two associations presented a 64-fold decrease against a resistant strain of Staphylococcus aureus, however, at a cytotoxic concentration. It can also be highlighted that when tested at a non-cytotoxic concentration, the activity of oregano in association with penicillin V presented an eight-fold decrease. These results show the interest to use essential oils in combination with antibiotics to reduce their concentrations inside drugs.

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Section: Discussionsupporting

confidence: 58%

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

et al. 2020

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“…Later, in a randomized controlled trial of C. cassia hemoglobin A1C reduction in patients with type 2 diabetes, the treatment group received two C. cassia capsules (500 mg each) per day for 90 days, and one of the subjects developed a rash, which subsided after discontinuation, but no further adverse reactions were observed [110]. In 2018, a 13-week repeat-dose oral toxicity study revealed that body weights of rats were normal, the weight of kidney/live and the level of total cholesterol were increased after receiving WEBC at up to 2000 mg/kg, but it was not mutagenic or clastogenic [111]. Later, a 8-week repeat-dose oral toxicity study revealed that renal function showed a significant increase, kidney and liver histology showed distortions in hepatocytes and sinusoidal linings with infiltrations, degenerative changes in glomerular and Bowman’s capsules with fibrillary mesangial interstitium after receiving CcAgNPs at up to 200 mg/kg [112].…”

Section: Toxicitymentioning

confidence: 99%

Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

et al. 2019

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Cinnamomum cassia Presl is a tropical aromatic evergreen tree of the Lauraceae family, commonly used in traditional Chinese medicine. It is also a traditional spice, widely used around the world. This paper summarizes the achievements of modern research on C. cassia, including the traditional uses, phytochemistry, pharmacology and toxicology. In addition, this review also discusses some significant issues and the potential direction of future C. cassia research. More than 160 chemicals have been separated and identified from C. cassia. The main constituents of C. cassia are terpenoids, phenylpropanoids, glycosides, etc. Modern studies have confirmed that C. cassia has a wide range of pharmacological effects, including antitumour, anti-inflammatory and analgesic, anti-diabetic and anti-obesity, antibacterial and antiviral, cardiovascular protective, cytoprotective, neuroprotective, immunoregulatory effects, anti-tyrosinase activity and other effects. However, the modern studies of C. cassia are still not complete and more in-depth investigations need to be conducted in alimentotherapy, health product, toxicity and side effects, and more bioactive components and potential pharmacological effects need to be explored in the future.

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“…These findings were in line with previous studies who reported the inhibitory effect of nanoparticles which hinder the antioxidative system. [31][32][33] Although after the CMBE supplementations with pre-treatment of Ni-NPs we observed considerable improvements in antioxidant levels (CAT and GSH) and reduction of the oxidation by-products (LPO and MDA) in liver and kidneys than only Ni-NPs treated group (NG). The antioxidant properties of C. cassia against Ni-NPs-induced oxidative stress was similar to findings of Shakeel et al 14 who reported a significant dose-dependent decrease of MDA and increase of anti-oxidant enzymes GPX, SOD, and CAT due to C. cassia oral administration in titanium oxide (TiO 2 NPs) exposed Sprague Dawley rats.…”

Section: Discussionmentioning

confidence: 99%

Cinnamomum cassia ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley rats

et al. 2020

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Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can ameliorate NPs-associated pathophysiologies. The present study examined Cinnamomum cassia ( C. cassia) bark extracts (CMBE) for its ameliorative activity against Ni-NPs-induced pathophysiological and histopathological alterations in male Sprague Dawley rats. The biochemical analyses revealed that dosing rats with Ni-NPs at 10 mg/kg/body weight (b.w.) significantly altered the normal structural and biochemical adaptations in the liver and kidney. Conversely, supplementations with CMBE at different doses (225, 200, and 175 mg/kg/b.w. of rat) ameliorated the altered blood biochemistry and reduced the biomarkers of liver and kidney function considerably ( p < 0.05) in a dose-dependent manner. However, the best results were at 225 mg/kg/b.w. of rat. The study provided preliminary information about the protective effect of C. cassia against Ni-NPs indicated liver and kidney damages. Future investigations are needed to explore C. cassia mechanism of action of C. cassia and isolation of single constituents of C. cassia to assess their pharmaceutical importance accordingly.

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In vitro and in vivo safety studies of cinnamon extract ( Cinnamomum cassia ) on general and genetic toxicology

Cited by 44 publications

References 47 publications

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Cinnamomum cassia ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley rats

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