2023
DOI: 10.3390/molecules28227470
|View full text |Cite
|
Sign up to set email alerts
|

In Vitro and In Vivo Biological Evaluation of Indole-thiazolidine-2,4-dione Derivatives as Tyrosinase Inhibitors

Li Lu,
Chunmei Hu,
Xiaofeng Min
et al.

Abstract: Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2,4-dione derivatives 5a~5z were synthesized by incorporating indole with thiazolidine-2,4-dione into one compound and assayed for their biological activities. All compounds displayed tyrosinase inhibitory activities and 5w had the highest anti-tyrosinase inhibitory activity with an IC50 value of 11.2 μM. Inhibition kinetics revealed 5w… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(1 citation statement)
references
References 45 publications
0
1
0
Order By: Relevance
“…The first reaction process is monophenolase activity, in which L-tyrosine is hydroxylated into L-dopa and the second reaction process is diphenolase activity, in which L-dopa is subsequently oxidized into dopaquinone ( Djafarou et al, 2023 ; Lee et al, 2023 ; Zargaham et al, 2023 ). In the organism, melanin acts crucial roles to protect the skin from UV radiation ( Lu et al, 2023a ; Znajafi et al, 2023 ). But, excessive elevated melanin content leads to lots of pigmentation disorders, including age spots and melanoma ( Broulier et al, 2023 ; De Barros et al, 2023 ; Xue et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%
“…The first reaction process is monophenolase activity, in which L-tyrosine is hydroxylated into L-dopa and the second reaction process is diphenolase activity, in which L-dopa is subsequently oxidized into dopaquinone ( Djafarou et al, 2023 ; Lee et al, 2023 ; Zargaham et al, 2023 ). In the organism, melanin acts crucial roles to protect the skin from UV radiation ( Lu et al, 2023a ; Znajafi et al, 2023 ). But, excessive elevated melanin content leads to lots of pigmentation disorders, including age spots and melanoma ( Broulier et al, 2023 ; De Barros et al, 2023 ; Xue et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%