In Vitro and In Vivo Antihyperglycemic Effects of New Metabiotics from Boletus edulis

Abstract

The increasing incidence of diabetes has prompted the need for new treatment strategies, including natural products that reduce glycemia values. This work examined the in vitro and in vivo antihyperglycemic effects of new metabiotics derived from Boletus edulis extracts. The metabiotics were obtained from 100% B. edulis, and two other products, CARDIO and GLYCEMIC, from Anoom Laboratories SRL, which contain other microbial species related to B. edulis. Our in vitro investigations (simulations of the microbiota of patients with type 2 diabetes (T2D)) demonstrated that B. edulis extracts modulate the microbiota, normalizing its pattern. The effects were further tested in vivo, employing a mouse model of T2D. The tested extracts decreased glycemia values compared to the control and modulated the microbiota. The metabiotics had positive effects on T2D in vitro and in vivo, suggesting their potential to alleviate diabetes-associated microbiota dysbiosis.

Boletus griseipurpureus Corner: Antibacterial, Antioxidant Properties and Phytochemical Compositions

“…7 Notably, mushrooms like B. edulis demonstrate remarkable antioxidant properties and possess antihyperglycemic effects. 8 Additionally, polysaccharide extracts derived from mushrooms showcase significant antioxidant properties 9 .…”

Identification of characteristic flavor compounds of boletus edulis from different regions based on by E-nose, HS-GC-IMS and HS-SPME-GC–MS

“…Boletus edulis is a wild edible mushroom that attracts large groups of consumers with its high nutritional value and unique flavor ( Liuzzi et al, 2023 ; Tan et al, 2022 ). Proteins, amino acids, and other nutrients are abundant in Boletus edulis , while physiological active functions such as hypoglycemia, anti-inflammation, and regulation of intestinal microorganisms are also part of its repertoire ( Avram et al, 2023 ; Zanfirescu et al, 2024 ). In addition, a unique flavor of Boletus edulis is often one of the reasons why it is chosen by consumers ( Huang et al, 2023 ).…”