In vitro and in vivo characterization of mineralized hydroxyapatite/polycaprolactone-graphene oxide based bioactive multifunctional coating on Ti alloy for bone implant applications

Murugan, Nagaraj; Murugan, Chandran; Sundramoorthy, Ashok K.

doi:10.1016/j.arabjc.2018.03.020

Cited by 86 publications

(43 citation statements)

References 41 publications

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“…The inhibitory zone by agar disc diffusion method (at 37 °C for 24 h) of 10 wt. % PCL/HA/GO composite at different doses (25, 50, 75 and 100 μl) against S. aureus was 10, 11, 14, 16 mm and E. coli was 10.5, 12, 14.5, 16.5 and 20.5 mm, respectively [107]. A good in vitro antibacterial ability by SiO 2 -GO-HA composite against E. coli and S. aureus using agar well diffusion method [108].…”

Section: Go-ha Nanocompositementioning

confidence: 99%

“…Zone of inhibition of: a) GO-HA against Enterococcus faecalis (A) and Pseudomonas aeruginosa (B)[106]; b) 10 wt. % PCL/HA/GO composite against S. aureus and E. coli[107]; c) silicate-based composites against E. coli and S. aureus by agar well diffusion method (after 48 h) and d) bar chart of antibacterial activity of silicate-based composites against E. coli and S. aureus[108].…”

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confidence: 99%

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Graphene Oxide-Modified Hydroxyapatite Nanocomposites in Biomedical Applications: A Review

Hashim¹,

Frankel²,

Nordin³

2019

Ceramics - Silikaty

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Bacterial infection and cytotoxicity associated with implant materials used in medical devices are the major cause of implant failures. This review focusses upon the development of graphene oxide (GO)-hydroxyapatite (HA) nanocomposites as potential coating materials that can provide a solution to the rejection of implants. These nanocomposites combine the unique antibacterial properties of graphene oxide with the natural mineral composition of hydroxyapatite, as found in human bones and tooth enamel. They have potential antibacterial applications in the fields of orthopaedics, orthodontics and cardiovascular medicine. The methods used for preparation of HA and GO in addition to the combining of GO-HA nanocomposite are discussed. Cytotoxicity and antibacterial affects of GO and GO-HA to biological systems are examined as well as future applications in related fields.

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Section: Go-ha Nanocompositementioning

confidence: 99%

mentioning

confidence: 99%

Graphene Oxide-Modified Hydroxyapatite Nanocomposites in Biomedical Applications: A Review

Hashim¹,

Frankel²,

Nordin³

2019

Ceramics - Silikaty

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“…Furthermore, the porous-like structure of the composite coating could contribute to the growth and integration of bone. The indentation tests revealed that the combination of PCL, HA, and GO dramatically improved the mechanical properties, in terms of hardness, that can be due to the presence of GO, which contains epoxide and hydroxyl groups on the basal plane, as well as carboxyl and carbonyl moieties on its edges [122].…”

Section: Nano-and Micro-indentationmentioning

confidence: 99%

“…In this work, the authors demonstrated a high adhesion strength of the coated PCL/GO/HA composite (29.6 ± 0.4 MPa), suitable for high load bearing applications. Interestingly, they reported that low concentrations of GO improved the mechanical properties of HA/PCL-based composite coatings [122].…”

Section: Peel (Or Adhesion) Testsmentioning

confidence: 99%

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

et al. 2020

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The understanding of chemical–physical, morphological, and mechanical properties of polymer coatings is a crucial preliminary step for further biological evaluation of the processes occurring on the coatings’ surface. Several studies have demonstrated how surface properties play a key role in the interactions between biomolecules (e.g., proteins, cells, extracellular matrix, and biological fluids) and titanium, such as chemical composition (investigated by means of XPS, TOF-SIMS, and ATR-FTIR), morphology (SEM–EDX), roughness (AFM), thickness (Ellipsometry), wettability (CA), solution–surface interactions (QCM-D), and mechanical features (hardness, elastic modulus, adhesion, and fatigue strength). In this review, we report an overview of the main analytical and mechanical methods commonly used to characterize polymer-based coatings deposited on titanium implants by electro-assisted techniques. A description of the relevance and shortcomings of each technique is described, in order to provide suitable information for the design and characterization of advanced coatings or for the optimization of the existing ones.

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“…Martinelli et al [ 184 ] reported promising bone regeneration properties of nano HAP-CNT thin films developed on biomedical stainless steel via an in vitro osteogenesis study. Murugan, Murugan and Sundramoorthy [ 185 ] developed a biological coating based on hydroxyapatite/polycaprolactone-graphene oxide on Ti alloy. In vitro testing of this coating revealed outstanding cell viability, while in vivo testing in a rat model revealed bone formation after 28 days of implantation.…”

Section: Biomimetic Role Of Hydroxyapatite and Carbon Composite Mamentioning

confidence: 99%

A Review on the Use of Hydroxyapatite-Carbonaceous Structure Composites in Bone Replacement Materials for Strengthening Purposes

2018

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Biomedical materials constitute a vast scientific research field, which is devoted to producing medical devices which aid in enhancing human life. In this field, there is an enormous demand for long-lasting implants and bone substitutes that avoid rejection issues whilst providing favourable bioactivity, osteoconductivity and robust mechanical properties. Hydroxyapatite (HAp)-based biomaterials possess a close chemical resemblance to the mineral phase of bone, which give rise to their excellent biocompatibility, so allowing for them to serve the purpose of a bone-substituting and osteoconductive scaffold. The biodegradability of HAp is low (Ksp ≈ 6.62 × 10−126) as compared to other calcium phosphates materials, however they are known for their ability to develop bone-like apatite coatings on their surface for enhanced bone bonding. Despite its favourable bone regeneration properties, restrictions on the use of pure HAp ceramics in high load-bearing applications exist due to its inherently low mechanical properties (including low strength and fracture toughness, and poor wear resistance). Recent innovations in the field of bio-composites and nanoscience have reignited the investigation of utilising different carbonaceous materials for enhancing the mechanical properties of composites, including HAp-based bio-composites. Researchers have preferred carbonaceous materials with hydroxyapatite due to their inherent biocompatibility and good structural properties. It has been demonstrated that different structures of carbonaceous material can be used to improve the fracture toughness of HAp, as they can easily serve the purpose of being a second phase reinforcement, with the resulting composite still being a biocompatible material. Nanostructured carbonaceous structures, especially those in the form of fibres and sheets, were found to be very effective in increasing the fracture toughness values of HAp. Minor addition of CNTs (3 wt.%) has resulted in a more than 200% increase in fracture toughness of hydroxyapatite-nanorods/CNTs made using spark plasma sintering. This paper presents a current review of the research field of using different carbonaceous materials composited with hydroxyapatite with the intent being to produce high performance biomedically targeted materials.

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In vitro and in vivo characterization of mineralized hydroxyapatite/polycaprolactone-graphene oxide based bioactive multifunctional coating on Ti alloy for bone implant applications

Cited by 86 publications

References 41 publications

Graphene Oxide-Modified Hydroxyapatite Nanocomposites in Biomedical Applications: A Review

Graphene Oxide-Modified Hydroxyapatite Nanocomposites in Biomedical Applications: A Review

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

A Review on the Use of Hydroxyapatite-Carbonaceous Structure Composites in Bone Replacement Materials for Strengthening Purposes

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