Abstract:ObjectivesBacterial infection following spinal fusion is a major clinical concern with up to 20% incidence. An ultrasound‐triggered bulk‐release system to combat postsurgical bacterial survival was designed and evaluated.MethodsPolylactic acid (PLA) clips were loaded with vancomycin (VAN) and microbubbles (Sonazoid, GE HealthCare) in vitro. Stability was determined over 14 days. VAN‐loaded clips were submerged in water and insonated using a Logiq E10 scanner (GE HealthCare) with a curvilinear C6 probe. Doppler… Show more
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