2011
DOI: 10.1016/j.jsbmb.2011.03.018
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In vitro and in vivo effects of a cyclooxygenase-2 inhibitor nimesulide analog JCC76 in aromatase inhibitors-insensitive breast cancer cells

Abstract: Third generation aromatase inhibitors (AIs) are more effective than tamoxifen in the treatment of estrogen receptor (ER) positive breast cancer. However, long-term use of AIs commonly results in resistance. We examined whether compound JCC76{Cyclohexanecarboxylic acid [3-(2,5-dimethyl-benzyloxy)-4-(methanesulfonyl-methyl-amino)-phenyl]-amide}, an analog of Cyclooxygenase-2 (COX-2) inhibitor nimesulide, can inhibit the growth of AI-insensitive breast cancer cells and the mechanisms by which the compound affects… Show more

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Cited by 14 publications
(15 citation statements)
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“…It is not surprising that the more potent JCC76 analog CSUOH0901 exhibits better potency to induce cell apoptosis. However, JCC76 did not show good potency to cause cell cycle arrest in previous studies [39,40]. CSUOH0901 obviously exhibited the cell G2/M phase arresting activity.…”
Section: Resultsmentioning
confidence: 81%
See 1 more Smart Citation
“…It is not surprising that the more potent JCC76 analog CSUOH0901 exhibits better potency to induce cell apoptosis. However, JCC76 did not show good potency to cause cell cycle arrest in previous studies [39,40]. CSUOH0901 obviously exhibited the cell G2/M phase arresting activity.…”
Section: Resultsmentioning
confidence: 81%
“…The results demonstrate that CSUOH0901 was able to inhibit cell mitosis and induce cell apoptosis at similar dosage to inhibit cell growth. JCC76 has been shown in previous studies to induce cell apoptosis via cytochrome c release [39,40] . It is not surprising that the more potent JCC76 analog CSUOH0901 exhibits better potency to induce cell apoptosis.…”
Section: Resultsmentioning
confidence: 99%
“…The arylsulfonamide JCC76 (2.7) is an Hsp27 inhibitor identified during the optimization of anticancer agents with unknown mechanism of action [39]. The biotinylated arylsulfonamide 2.8 (Figure 2.1) strongly binds to a-and b-tubulin, and to Hsp27 in breast cancer cells [40].…”
Section: Hsp27mentioning
confidence: 99%
“…In breast carcinoma cell lines, however, it is also true that aromatase mRNA expression or enzymatic activity is in general below the detection level [43][44][45]. Therefore, aromatase transfected cell lines such as MCF-7aro and T-47Daro have been established by some investigators and used in many laboratories [46][47][48]. This discrepancy in terms of aromatase expression between intratumoral carcinoma cells derived from patients and breast carcinoma cell lines is considered to be at least partly due to the lack of interaction of parenchymal or carcinoma cells and stromal cells [5].…”
Section: Co-culture Vs Mono-culture In Aromatase Expression and Actimentioning
confidence: 99%