In vitro and in vivo anti-Cryptosporidium and anti-inflammatory effects of Aloe vera gel in dexamethasone immunosuppressed mice

Farid, Alyaa; Tawfik, Ali; Elsioufy, Basil; Safwat, Gehan

doi:10.1016/j.ijpddr.2021.09.002

Cited by 21 publications

(13 citation statements)

References 66 publications

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“…Figure 4 shows the contact angle measurement over time after the collapse of the xerogel sample. Both results were expected because of the presence of functional groups, which were predominantly polar in the hydrogel [10,19].…”

Section: Contact Anglementioning

confidence: 61%

“…In 2020, the global Aloe vera hydrogel market was valued at 649.41 million USD, with the pharmaceutical industry being the main end-user with 61% of consumption [5]. Aloe vera extracts are widely used to treat skin lesions due to their healing, anti-inflammatory, analgesic, vasodilatory, and antimicrobial properties [6][7][8][9][10]. The complex composition of the hydrogel includes about 75 potential compounds, including minerals and phenolics [5,11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Differences in the composition of Aloe vera hydrogels are related to geographical and seasonal variations and the elaboration process [5,12]. In some studies, the selected leaves were rinsed with water or even with a mild chlorine solution as a disinfectant [10,35].…”

Section: Introductionmentioning

confidence: 99%

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Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

et al. 2021

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Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.

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Section: Contact Anglementioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

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Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

et al. 2021

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“…Animals were anesthetized by ether inhalation at the end of 8 weeks and 16 weeks intake of sweeteners. Blood was collected from jugular vein with EDTA (anti-coagulant) [9][10]. The non-coagulated blood was used to count red blood cells (RBCs), white blood cells (WBCs), platelet (PLT), and to measure haemoglobin (Hb) and haematocrit (HCT) percentage.…”

Section: Blood Haematological Parametersmentioning

confidence: 99%

“…Specimens from liver, kidney, urinary bladder, and pancreas were fixed immediately in 10% neutral buffered formalin, dehydrated in different grades of alcohol, cleared in xylol, embedded in paraffin wax, sectioned at 4-6 μ thick and stained with haematoxylin and Eosin (H&E) according to Farid et al [9][10] and examined microscopically.…”

Section: Histopathological Studymentioning

confidence: 99%

Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model

et al. 2021

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Background: Sucralose and saccharin-cyclamate mixture are considered as safe commercial artificial sweeteners with many health authorities instead of natural sugar. We aimed to reveal their effects on the physiological, immunological and histological profiles. Methods and results mg/ml) in drinking water for 8 and 16 weeks. Only sucralose caused a temporary significant increase in blood glucose after 8 weeks that was eliminated after 16 weeks. WBCs count was decreased significantly after 16 weeks of sucralose administration. Aspartate aminotransferase creatinine (Cr) recorded an increase at 8 and 16 weeks due to the two artificial sweeteners intake. Both artificial sweetener induced a significant increase in interleukin (IL (LPS) levels with a progress from 8 th to 16 damage in kidney, liver, pancreas and urinary bladder. saccharin-cyclamate mixture, their chronic bladder. Moreover, they may interrupt the intestinal barriers leading to an cytokine secretions.

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Therapeutic Properties of Herbal Constituents Subjected for Clinical Trials

Vatsa,

Aggarwal

2023

Bioprospecting of Tropical Medicinal Plants

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In vitro and in vivo anti-Cryptosporidium and anti-inflammatory effects of Aloe vera gel in dexamethasone immunosuppressed mice

Cited by 21 publications

References 66 publications

Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model

Therapeutic Properties of Herbal Constituents Subjected for Clinical Trials

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