“…Few works have explored the bioactivity of the bacterial EPS in relation to some diseases, which can be directly related to the immune state of the individual; this is the case of the intestinal colitis (Sengül et al 2006;Rodriguez et al 2009), arthritis (Nowak et al 2012), and some carcinogenic processes (Oda et al 1983;Kitazawa et al 1991;Kim et al 2010). More recently, studies of EPS bioactivity are focused on determining its potential as antioxidants, or free radical scavenging agents, to diminish damages and loss of function in many tissues caused by different reactive oxygen species (Sengül et al 2011;Xu et al 2011). It is worth to note that these studies are preliminary, most have been done in vitro and there is not demonstration of the efficacy in humans; besides, no mechanism of action have been proposed in order to explain how bacterial EPS could carry out such activities upon the biological tissues.…”