In vitro and in vivo approaches for the measurement of oral bioavailability of lead (Pb) in contaminated soils: A review

Zia, Munir; Codling, Eton E.; Scheckel, Kirk G.; Chaney, Rufus L.

doi:10.1016/j.envpol.2011.04.043

Cited by 116 publications

(83 citation statements)

References 105 publications

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“…At present, several in vivo animal modelsincluding mouse and swine have beenused to assess Pbrelative bioavailability (RBA, relative to water soluble lead acetate) [11][12][13][14].However, in vivo assays are costly and time consuming, therefore not suitable to measure site-specific Pb-RBA on a large scale. As a result, various in vitro assays to determine Pb bioaccessibility have been developed, whichmeasures the soluble Pb fraction from soil in simulatedhuman gastrointestinalfluids [10][11][15][16].…”

Section: Introductionmentioning

confidence: 99%

Lead bioaccessibility in 12 contaminated soils from China: Correlation to lead relative bioavailability and lead in different fractions

Cave

et al. 2015

Journal of Hazardous Materials

123

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HighlightsLead bioaccessibility in the gastric phase (GP) and Pb-RBA was generally lower in mining soils (0.4629%and 7.026%) than smelting (1992% and 3184%) and farming soils (1399% and 5161%), with more Pb in the residual fraction in mining soils. Lead bioaccessibilityvaried with assays, with SBRC (3.099%)producing significantly higher bioaccessible Pbthan other assays (0.4684%) in the gastric phase. However, Pb bioaccessibilityin the intestinal phase (IP) of all assays sharply decreased to 0.01-20%possibly due to Pbsorption to solid phase at higher pH. Lead bioaccessibility by UBM-GPassay was best correlated with Pb-RBA (r 2 =0.67), followed by IVG-GP (r 2 =0.55).Among different Pb fractions, strong correlation was found between Pb bioaccessibility/Pb-RBA andthe sum of exchangeable and carbonate fractions. Our study suggested thatUBM-GP assay has potential to determine Pbbioaccessibility in contaminated soils in China.

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Section: Introductionmentioning

confidence: 99%

Lead bioaccessibility in 12 contaminated soils from China: Correlation to lead relative bioavailability and lead in different fractions

Cave

et al. 2015

Journal of Hazardous Materials

123

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“…However, a surrogate for bioavailability, a class of in vitro test known as bioaccessibility testing has been developed and validated specifically for this purpose page 4 of 35 and is available to be used as a conservative estimate of bioavailability. The development of bioaccessibility testing methods for Pb in soil has recently been comprehensively reviewed (Zia et al, 2011). In general the bioaccessibility tests fall into two categories: (i) those which try to closely mimic the physiological conditions in the stomach and upper intestine DIN, 2000;Oomen et al, 2002;Wragg et al, 2011) and (ii) methods which use a simplified extraction media ( (Drexler and Brattin, 2007;Zia et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Although there is still some discussion over the relative merits of the different methodologies (Zia et al, 2011), the method adopted by this study is the Unified BARGE method (UBM) which has undergone interlaboratory trials and been validated against a swine model for Pb (Caboche, 2009;Denys et al, 2012). The fraction of a PHE assessed in an in vitro bioaccessibility assay is that which is released from the soil into solution in the gastro-intestinal (GI) tract in a form that can potentially be absorbed into the blood stream (Paustenbach, 2000;Wragg and Cave, 2003;Intawongse and Dean, 2006).…”

Section: Introductionmentioning

confidence: 99%

Modelling lead bioaccessibility in urban topsoils based on data from Glasgow, London, Northampton and Swansea, UK

Appleton

Cave

Wragg

2012

Environmental Pollution

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Predictive linear regression (LR) modelling between bioaccessible Pb and a range of total elemental compositions and soil properties was executed for the Glasgow, London, Northampton and Swansea urban areas in order to assess the potential for developing a national urban bioaccessible Pb dataset for the UK. LR indicates that total Pb is the only highly significant independent variable for estimating the bioaccessibility of Pb.Bootstrap resampling shows that the relationship between total Pb and bioaccessible Pb is broadly the same in the four urban areas. The median bioaccessible fraction ranges from 38% in Northampton to 68% in London and Swansea. Results of this study can be used as part of a lines of evidence approach to localised risk assessment but should not be used to replace bioaccessibility testing at individual sites where local conditions may vary considerably from the broad overview presented in this study. Capsule AbstractTotal Pb is the only significant predictor for bioaccessible Pb in topsoils from four urban areas in the UK.

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“…Understanding the spatial patterns of soil lead can elucidate sources in the environment and facilitate a broader appreciation for the processes that shape our urban places [44]. In addition to total lead, testing for bioavailable or bioaccessible lead can determine whether soil amendments are successful at reducing potential exposure [45,46]. Minca et al [46] provide a decision table regarding the use of a bioaccessible lead test for urban soils with an emphasis on food production.…”

Section: Soil Management Amendments and Testingmentioning

confidence: 99%

Growing Gardens in Shrinking Cities: A Solution to the Soil Lead Problem?

et al. 2016

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Abstract:As cities shrink, they often leave a patchwork of vacancy on the landscape. The maintenance of vacant lands and eventual transformation to sustainable land uses is a challenge all cities face, but one that is particularly pronounced in shrinking cities. Vacant lands can support sustainability initiatives, specifically the expansion of urban gardens and local food production. However, many shrinking cities are the same aging cities that have experienced the highest soil lead burdens from their industrial past as well as the historic use of lead-based paint and leaded gasoline. Elevated soil lead is often viewed as a barrier to urban agriculture and managing for multiple ecosystem services, including food production and reduced soil lead exposure, remains a challenge. In this paper, we argue that a shift in framing the soil lead and gardening issue from potential conflict to potential solution can advance both urban sustainability goals and support healthy gardening efforts. Urban gardening as a potential solution to the soil lead problem stems from investment in place and is realized through multiple activities, in particular (1) soil management, including soil testing and the addition of amendments, and (2) social network and community building that leverages resources and knowledge.

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In vitro and in vivo approaches for the measurement of oral bioavailability of lead (Pb) in contaminated soils: A review

Cited by 116 publications

References 105 publications

Lead bioaccessibility in 12 contaminated soils from China: Correlation to lead relative bioavailability and lead in different fractions

Lead bioaccessibility in 12 contaminated soils from China: Correlation to lead relative bioavailability and lead in different fractions

Modelling lead bioaccessibility in urban topsoils based on data from Glasgow, London, Northampton and Swansea, UK

Growing Gardens in Shrinking Cities: A Solution to the Soil Lead Problem?

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