In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity

Wang, Yancai; Ma, Yingying; Zheng, Ying; Song, Jun‐Yeob; Yang, Xiao; Bi, Chao; Zhang, Dianrui; Zhang, Qiang

doi:10.1016/j.ijpharm.2012.10.021

Cited by 89 publications

(53 citation statements)

References 39 publications

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“…Wang and coworkers evaluated the anticancer activity of puerarin nanosuspensions in human colon cancer HT-29 cell lines in vitro and in vivo, with the aim of reducing the serious adverse effects of free puerarin. 118 It was found that puerarin nanosuspensions could significantly enhance the in vitro antiproliferation of HT-29 cells compared to the free puerarin solution. After intravenous administration of puerarin nanosuspensions, tumor growth and toxicity were significantly reduced compared to the control group in an experimental model of colon tumor-bearing mice.…”

Section: -105mentioning

confidence: 99%

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

et al. 2016

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Section: -105mentioning

confidence: 99%

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

et al. 2016

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“…At present, about 40% of the drugs in the pipelines and up to 70% of molecules 25 coming from synthesis have solubility problems and consequently poor oral 26 bioavailability and delivery problems [1]. To address this issue, researchers have 27 developed multiple techniques, e.g.…”

Section: Introductionmentioning

confidence: 99%

The construction of puerarin nanocrystals and its pharmacokinetic and in vivo–in vitro correlation (IVIVC) studies on beagle dog

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Wang et al [172] studied in vitro the anti-colorectal cancer activity of puerarin nanosuspensions of lecithin and hydroxypropyl methylcellulose (HPMC) in the human colon cancer HT-29 cell line. Cytotoxicity assay, observation of morphological changes and early apoptosis revealed that puerarin nanosuspensions could significantly enhance the in vitro anti-proliferation effect against HT-29 cells compared to the puerarin-free solution (Table 3).…”

Section: In Vitro and In Vivo Responses To Bio-based Nanostructuresmentioning

confidence: 99%

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

et al. 2015

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The development of bio-based nanostructures as nanocarriers of bioactive compounds to specific body sites has been presented as a hot topic in food, pharmaceutical and nanotechnology fields. Food and pharmaceutical industries seek to explore the huge potential of these nanostructures, once they can be entirely composed of biocompatible and non-toxic materials. At the same time, they allow the incorporation of lipophilic and hydrophilic bioactive compounds protecting them against degradation, maintaining its active and functional performance. Nevertheless, the physicochemical properties of such structures (e.g., size and charge) could change significantly their behavior in the gastrointestinal (GI) tract. The main challenges in the development of these nanostructures are the proper characterization and understanding of the processes occurring at their surface, when in contact with living systems. This is crucial to 2 understand their delivery and absorption behavior as well as to recognize potential toxicological effects. This review will provide an insight into the recent innovations and challenges in the field of delivery via GI tract using bio-based nanostructures. Also, an overview of the approaches followed to ensure an effective deliver (e.g., avoiding physiological barriers) and to enhance stability and absorptive intestinal uptake of bioactive compounds will be provided. Information about nanostructures' potential toxicity and a concise description of the in vitro and in vivo toxicity studies will also be given.

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In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity

Cited by 89 publications

References 39 publications

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

The construction of puerarin nanocrystals and its pharmacokinetic and in vivo–in vitro correlation (IVIVC) studies on beagle dog

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

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