In-vitro and in-vivo erosion profiles of hydroxypropylmethylcellulose (HPMC) matrix tablets

Ghimire, Manish; Hodges, Lee Ann; Band, Janet; O'Mahony, Bridget; McInnes, Fiona; Mullen, Alexander B.; Stevens, H. N. E.

doi:10.1016/j.jconrel.2010.06.015

Cited by 67 publications

(40 citation statements)

References 44 publications

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“…As can be seen in this study , when a system composed of hydrophylic polymers like HPMC and XG gets in contact with aqueous medium, the medium difuses into the system [16,17,21]. Polymer at surface turns into a gel at first.…”

Section: In Vitro Drug Release From Matrix Tabletsmentioning

confidence: 61%

Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol formulated with polymers and waxes

Yener¹,

Ayçiçek²,

Üner³

et al. 2017

Trop. J. Pharm Res

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Section: In Vitro Drug Release From Matrix Tabletsmentioning

confidence: 61%

Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol formulated with polymers and waxes

Yener¹,

Ayçiçek²,

Üner³

et al. 2017

Trop. J. Pharm Res

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“…In contact with water, HPMC swells to form a gel, which acts as a barrier to drug diffusion. In addition, it is reported that increasing HPMC concentration or using higher viscosity grades increases the strength of the gel layer and retards the penetration of water thus delaying drug dissolution (Ghimire et al, 2010). In addition, this might be attributed to the swelling behavior of HPMC E15 that leads to increasing viscosity of the dissolution medium and hence retarding drug dissolution (Colombo et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

The Flow-Through Cell as an In Vitro Dissolution Discriminative Tool for Evaluation of Gliclazide Solid Dispersions

2017

J App Pharm Sci

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Gliclazide (GLZ) is used to treat type II diabetes mellitus. It is a poorly soluble drug with variable bioavailability. The aim of this study was to improve GLZ solubility and dissolution rate by mixing or cogrinding with different polymers (PEG 4000, PEG 8000, MCC, HPMC E15 and alginates). Dissolution of two commercial products was carried out for comparison. GLZ solubility in phosphate buffer (pH 7.4) showed that grinding of GLZ considerably increased its solubility while, other polymers did not affect GLZ solubility. Flow-through cell (FTC) dissolution apparatus with two patterns of GLZ powder loading were utilized to achieve sensitive and reproducible dissolution data. Results revealed that distribution of untreated and ground GLZ powder with large volume of glass beads gave the best dissolution profiles in terms of rapid onset of dissolution (Q5min) and dissolution efficiency (DE60min). The best excipient among all was PEG (4000 and 8000), where GLZ physical mixture (PM) enhanced the dissolution rate without co-grinding to form solid dispersion (CSD). The highest dissolution rate and extent were obtained from GLZ:PEG 4000 (1:5) PM, where about 45.88 % was dissolved after 5 min and DE60min was 74.18%.

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“…When the percentage of HPMC K15M increases, the swelling process is more isotropic (Wang et al, 2009) since the integrity and shape of the gel are maintained with respect the original shape (see Fig. 4), in addition to having a better in vitro-in vivo correlation (Ghimire et al, 2010).…”

Section: Dissolution Profilesmentioning

confidence: 99%

Quality by Design approach to understand the physicochemical phenomena involved in controlled release of captopril SR matrix tablets

Saurí

Millán

Suñé-Negre

et al. 2014

International Journal of Pharmaceutics

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In-vitro and in-vivo erosion profiles of hydroxypropylmethylcellulose (HPMC) matrix tablets

Cited by 67 publications

References 44 publications

Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol formulated with polymers and waxes

Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol formulated with polymers and waxes

The Flow-Through Cell as an In Vitro Dissolution Discriminative Tool for Evaluation of Gliclazide Solid Dispersions

Quality by Design approach to understand the physicochemical phenomena involved in controlled release of captopril SR matrix tablets

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