In vitro and in vivo isolation ofLeishmania tropica from Saudi Arabia

Mahmoud, Ahmed; Al-Tuwaijri, Ali S.; Al-Mofleh, Ibrahim; Al-Khuwaitir, S. A.

doi:10.1007/bf00927746

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1987

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“…Promastigotes of L. major cultured in Novy, MacNeal and Nicolle's (NNN) medium as described by Mahmoud et al (1985) were harvested, concentrated by centrifugation at 900 rpm for 30 min, suspended in 15 ml of the fluid phase of the medium and counted by microscopy in a haemocytometer. Each mouse treated with glucan or dextrose was given a subcutaneous injection of 5 x lo7 promastigotes.…”

Section: Treatment and Infectionmentioning

confidence: 99%

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Effect of glucan on Leishmania major infection in BALB/c mice

Tuwaijri

Mahmoud

Mofleh

et al. 1987

Journal of Medical Microbiology

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Summary. The effect of glucan on Leishmania major infection was studied in BALB/c mice, which are highly susceptible to leishmania infection. Glucan (0.45 mg), or isovolumetric dextrose, was administered intraperitoneally 7, 5, 3 and 1 day before infection with L. major promastigotes. At 3, 5, 6, 8 and 10 weeks after infection, animals were killed; the liver and spleen of each animal were weighed and the parasite burden was calculated. A significant (p < 0.01) reduction in amastigote proliferation in liver and spleen of animals pretreated with glucan was demonstrated 4,6 and 8 weeks after infection.

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Section: Treatment and Infectionmentioning

confidence: 99%

“…Hospital, Riyadh, Saudi Arabia, and maintained in vitro and in vivo in this laboratory as described earlier (Mahmoud et al, 1985). Inbred BALB/c male mice weighing 20-25 g were kept in air-conditioned quarters with food and water provided ad libitum.…”

Section: Introductionmentioning

confidence: 99%