In vitro and in vivo impairment of embryo implantation by commonly used fungicide Mancozeb

Akthar, Ihshan; Wang, Ziyi; Wijayagunawardane, Missaka P.B.; Ratnayake, Chathura; Siriweera, E. H.; Lee, Ckf; Kodithuwakku, Suranga P.

doi:10.1016/j.bbrc.2020.04.051

Cited by 15 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Six studies analyze other different endocrine disruptors [ 52 , 53 , 54 , 55 , 56 , 57 ]. The use of benzo(a)- pyrene (BaP) led to a significant decrease of implantation sites in the study groups treated with doses of 0.2 and 20 mg/kg.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies

Caserta

Costanzi

Marco

et al. 2021

IJERPH

View full text Add to dashboard Cite

Several available studies have already analyzed the systemic effects of endocrine-disrupting chemicals (EDCs) on fertile woman and neonatal outcomes, but little is still known in humans about the precise mechanisms of interference of these compounds with the endometrial receptivity. There is consistent evidence that continuous and prolonged exposure to EDCs is a risk factor for reduced fertility and fecundity in women. Preliminary studies on mammalian models provide robust evidence about this issue and could help gynecologists worldwide to prevent long term injury caused by EDCs on human fertility. In this systematic review, we aimed to systematically summarize all available data about EDC effects on blastocyst endometrial implantation. We performed a systematic review using PubMed®/MEDLINE® to summarize all in vivo studies, carried out on mice models, analyzing the molecular consequences of the prolonged exposure of EDC on the implantation process. 34 studies carried out on mouse models were included. Primary effects of EDC were a reduction of the number of implantation sites and pregnancy rates, particularly after BPA and phthalate exposure. Furthermore, the endometrial expression of estrogen (ER) and progesterone receptors (PR), as well as their activation pathways, is compromised after EDC exposure. Finally, the expression of the primary endometrial markers of receptivity (such as MUC1, HOXA10, Inn and E-cadherin) after EDC contact was analyzed. In conclusion EDC deeply affect blastocyst implantation in mouse model. Several players of the implantation mechanism are strongly influenced by the exposure to different categories of EDC.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The analysis of fungicides effects on implantation process was analyzed by two studies; the study chemicals were mancozeb [ 56 ] and azole fungicides [ 57 ], respectively. Both studies indicated a loss of implantation sites both in the pre-implantation and post-implantation phases.…”

Section: Resultsmentioning

confidence: 99%

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies

Caserta

Costanzi

Marco

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Reduced trophoblastic spheroid attachment to endometrial epithelial cells in MCZ exposed animals may be at least partially mediated by down-regulation of endometrial estrogen receptor β receptor and integrin β3 expression, whereas ETU itself did not possess such an inhibitory effect (63). In addition, even in the lack of significant changes of decidualization markers in endometrial stromal cells, MCZ suppressed decidualization-induced morphological changes in stroma cells that may be associated with altered Prostaglandin E synthase transcription and protein expression (64).…”

Section: Ovariesmentioning

confidence: 87%

Endocrine-disrupting activity of mancozeb

Skalny¹,

Aschner²,

Paoliello³

et al. 2021

Arhiv za farmaciju

View full text Add to dashboard Cite

The objective of the present study was to review the existing data on the mechanisms involved in the endocrine disrupting activity of mancozeb (MCZ) in its main targets, including thyroid and gonads, as well as other endocrine tissues that may be potentially affected by MCZ. MCZ exposure was shown to interfere with thyroid functioning through impairment of thyroid hormone synthesis due to inhibition of sodium-iodine symporter (NIS) and thyroid peroxidase (TPO) activity, as well as thyroglobulin expression. Direct thyrotoxic effect may also contribute to thyroid pathology upon MCZ exposure. Gonadal effects of MCZ involve inhibition of sex steroid synthesis due to inhibition of P450scc (CYP11A1), as well as 3b-HSD and 17b-HSD. In parallel with altered hormone synthesis, MCZ was shown to down-regulate androgen and estrogen receptor signaling. Taken together, these gonad-specific effects result in development of both male and female reproductive dysfunction. In parallel with clearly estimated targets for MCZ endocrine disturbing activity, namely thyroid and gonads, other endocrine tissues may be also involved. Specifically, the fungicide was shown to affect cortisol synthesis that may be mediated by modulation of CYP11B1 activity. Moreover, MCZ exposure was shown to interfere with PPARg signaling, being a key regulator of adipogenesis. The existing data also propose that endocrine-disrupting effects of MCZ exposure may be mediated by modulation of hypothalamus-pituitary-target axis. It is proposed that MCZ neurotoxicity may at least partially affect central mechanisms of endocrine system functioning. However, further studies are required to unravel the mechanisms of MCZ endocrine disrupting activity and overall toxicity.

show abstract

“…However, mancozeb is an endocrine disrupting substance, and has reproductive toxicity and neurotoxicity. 81,82 Recent studies have suggested that it could be a potential threat to human health, such as affecting sleep and neurodevelopment, and even posing a carcinogenic hazard. [83][84][85] Given the risks of fungicides, the search for biocontrol agents to reduce their use has been a hot topic of research.…”

Section: Field and Postharvest Application Of H17-16 To Control Potat...mentioning

confidence: 99%

Endophytic Bacillus subtilis H17‐16 effectively inhibits Phytophthora infestans, the pathogen of potato late blight, and its potential application

Zhang

Huang

Yang

et al. 2023

Pest Management Science

View full text Add to dashboard Cite

BACKGROUNDAs a highly prevalent epidemic disease of potato, late blight caused by Phytophthora infestans poses a serious threat to potato yield and quality. At present, Chemical fungicides are mainly used to control potato late blight, but long‐term overuse of chemical fungicides may lead to environmental pollution and human health threats. Endophytes, natural resources for plant diseases control, can promote plant growth, enhance plant resistance, and secrete antifungal substances. Therefore, there is an urgent need to find some beneficial endophytes to control potato late blight.RESULTSWe isolated a strain of Bacillus subtilis H17‐16 from potato healthy roots. It can significantly inhibit mycelial growth, sporangia germination and the pathogenicity of Phytophthora infestans, induce the resistance of potato to late blight, and promote potato growth. In addition, H17‐16 has the ability to produce protease, volatile compounds (VOCs) and form biofilms. After H17‐16 treatment, most of the genes involved in metabolism, virulence and drug resistance of Phytophthora infestans were down‐regulated significantly, and the genes related to ribosome biogenesis were mainly up‐regulated. Moreover, field and postharvest application of H17‐16 can effectively reduce the occurrence of potato late blight, and the combination of H17‐16 with chitosan or chemical fungicides had a better effect than single H17‐16.CONCLUSIONOur results reveal that Bacillus subtilis H17‐16 has great potential as a natural fungicide for controlling potato late blight, laying a theoretical basis for its development as a biological agent.This article is protected by copyright. All rights reserved.

show abstract

In vitro and in vivo impairment of embryo implantation by commonly used fungicide Mancozeb

Cited by 15 publications

References 23 publications

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies

Endocrine-disrupting activity of mancozeb

Endophytic Bacillus subtilis H17‐16 effectively inhibits Phytophthora infestans, the pathogen of potato late blight, and its potential application

Contact Info

Product

Resources

About