In vitro and in vivo antifungal activities of decursin and decursinol angelate isolated from Angelica gigas against Magnaporthe oryzae, the causal agent of rice blast

Equol, a Clinically Important Metabolite, Inhibits the Development and Pathogenicity of Magnaporthe oryzae, the Causal Agent of Rice Blast Disease

“…Correspondingly, kasugamycin was active to mycelial growth, with a 56% inhibition rate at 50 μg/mL, but was not efficient enough to inhibit the conidial germination of M . oryzae [ 38 ]. The EC 50 of equol to mycelia growth is more than 100 μg/mL, while 30 to 50 μg/mL equol inhibited conidial germination and appressoria formation efficiently, indicating that equol, in contrast to Kasugamycin, has a relatively strong inhibitory effect to conidial germination and appressoria formation than to mycelia growth.…”

Natural Korean Medicine Dang-Gui: Biosynthesis, Effective Extraction and Formulations of Major Active Pyranocoumarins, Their Molecular Action Mechanism in Cancer, and Other Biological Activities

“…In the alcohol extraction, major chemical substances are isolated from cham dang-gui ; pyranocoumarins that include decursin (D) (18.7–44.8 mg/g), decursinol angelate (DA) (11.1–36.8 mg/g), nodakenin (4.53–13.1 mg/g), demethylsuberosine (0.412–2.31 mg/g), decursinol (DOH) (0.083–0.431 mg/g) and marmesin (0.059–0.592 mg/g) [ 5 ]. Several research publications have documented anticancer and anti-inflammatory properties, and neuroprotective abilities, of AGN coumarins [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Biosynthesis of pyranocoumarins including decursin, decursinol angelate and decursinol takes place through the phenylpropanoid pathway in plants.…”

Evaluation of antifungal activities and structure-activity relationships of coumarin derivatives

“…To date, no reports pertaining to the antifungal activities of angular pyranocoumarins exist, and studies pertaining to the antifungal activities of linear pyranocoumarins are few. One report has indicated that decursin and decursinol angelate (linear pyranocoumarins isolated from Angelica gigas ) can effectively control rice blast by inhibiting Magnaporthe oryzae spore germination rather than mycelial growth . Although there are several studies addressing the antifungal activities of coumarins, no reports exist for the five major natural coumarin types (simple coumarins, linear furanocoumarins, angular furanocoumarins, linear pyranocoumarins and angular pyranocoumarins) against plant‐pathogenic fungi.…”