In vitro and in vivo evaluation of the delivery of topical formulations containing glycoalkaloids of Solanum lycocarpum fruits

Tiossi, Renata Fabiane Jorge; Costa, Juliana C. Da; Miranda, Mariza Abreu; Praça, Fabíola Silva Garcia; McChesney, James D.; Bentley, Maria Vitória Lopes Badra; Bastos, Jairo Kenupp

doi:10.1016/j.ejpb.2014.01.010

Cited by 16 publications

(6 citation statements)

References 32 publications

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“…In a related in vivo study, Tiossi et al used an extract of Solanum lycocarpum fruit containing 45% each of solamargine and solasonine to prepare a topical formulation and to optimize its penetration in vitro to porcine skin and in vivo to the skin of hairless mice. The results showed that pH 6.5 was optimal for delivery and penetration of skin in both animal models, suggesting that the formulation might be useful for topical therapy of skin disorders.…”

Section: Anticarcinogenic Properties Of Eggplant Glycoalkaloidsmentioning

confidence: 99%

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Friedman¹

2015

J. Agric. Food Chem.

174

106

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Inhibition of cancer can occur via apoptosis, a genetically directed process of cell self-destruction that involves numerous biomarkers and signaling pathways. Glycoalkaloids are nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants, potatoes, and tomatoes. Exposure of cancer cells to glycoalkaloids produced by eggplants (α-solamargine and α-solasonine), potatoes (α-chaconine and α-solanine), and tomatoes (α-tomatine) or their hydrolysis products (mono-, di-, and trisaccharide derivatives and the aglycones solasodine, solanidine, and tomatidine) inhibits the growth of the cells in culture (in vitro) as well as tumor growth in vivo. This overview comprehensively surveys and consolidates worldwide efforts to define the following aspects of these natural compounds: (a) their prevalence in the three foods; (b) their chemistry and structure-activity relationships; (c) the reported factors (biomarkers, signaling pathways) associated with apoptosis of bone, breast, cervical, colon, gastric, glioblastoma, leukemia, liver, lung, lymphoma, melanoma, pancreas, prostate, and squamous cell carcinoma cell lines in vitro and the in vivo inhibition of tumor formation and growth in fish and mice and in human skin cancers; and (d) future research needs. The described results may make it possible to better relate the structures of the active compounds to their health-promoting function, individually, in combination, and in food, and allow the consumer to select glycoalkaloid-containing food with the optimal content of nontoxic beneficial compounds. The described findings are expected to be a valuable record and resource for further investigation of the health benefits of food-related natural compounds.

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Section: Anticarcinogenic Properties Of Eggplant Glycoalkaloidsmentioning

confidence: 99%

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Friedman¹

2015

J. Agric. Food Chem.

174

106

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“…Several alkaloids isolated from natural herbs exhibit antiproliferative, antibacterial, antiviral, insecticidal, and antimetastatic effects on various types of cancers both in vitro and in vivo [ 101 ]. The glycoalkaloids solamargine ( 52 ) and solasonine ( 53 ) were identified in various species of the Solanaceae family [ 102 ], but S. lycocarpum stands out for the production of these compounds [ 103 ]. Solamargine ( 52 ) and solasonine ( 53 ) could function as antidiabetic compounds, since they inhibit the increase of rat serum glucose levels, probably by suppressing the transfer of sucrose from the stomach to the small intestine [ 100 ].…”

Section: Solanum Lycocarpum St Hillmentioning

confidence: 99%

“…Solamargine ( 52 ) and solasonine ( 53 ) have antitrypanosomal [ 98 , 106 ], schistosomicidal [ 107 ], antiherpetic [ 108 ], antifungal [ 109 , 110 ], immunomodulatory [ 99 ], and anticancer [ 111 , 112 , 113 , 114 ] activities. Formulations based on Solanum -derived glycoalkaloids may be useful for topical therapy of several skin disorders, mainly skin cancer, but also leishmaniasis, herpes, and dermatophytosis [ 103 , 115 ]. Recently, investigators reported a promising topical formulation containing solamargine ( 52 ) and solasonine ( 53 ) extracted from S. lycocarpum that allows the penetration of the glycoalkaloids into deeper skin layers, where cancerous lesions commonly take place [ 103 ].…”

Section: Solanum Lycocarpum St Hillmentioning

confidence: 99%

Bioactive Compounds Found in Brazilian Cerrado Fruits

Bailão

Devilla

Conceição

et al. 2015

IJMS

136

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Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive. Hence, the knowledge propagation about the importance of the species found in Cerrado could contribute to the preservation of this biome. This review provides information about Cerrado fruits and highlights the structures and pharmacologic potential of functional compounds found in these fruits. Compounds detected in Caryocar brasiliense Camb. (pequi), Dipteryx alata Vog. (baru), Eugenia dysenterica DC. (cagaita), Eugenia uniflora L. (pitanga), Genipa americana L. (jenipapo), Hancornia speciosa Gomes (mangaba), Mauritia flexuosa L.f. (buriti), Myrciaria cauliflora (DC) Berg (jabuticaba), Psidium guajava L. (goiaba), Psidium spp. (araçá), Solanum lycocarpum St. Hill (lobeira), Spondias mombin L. (cajá), Annona crassiflora Mart. (araticum), among others are reported here.

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“…Nevertheless, low chain alcohols were shown to act better as penetration enhancers in the case of 5-ALA. Its solution in the mixture of ethanol, isopropanol, and polyethylene glycol with tetraethylene glycol ether is superior to the newly proposed physical gel in terms of penetration. Tiossi and co-workers used commercial 2% physical hydrogel of HEC to deliver glycoalkaloids from Solanum lycocarpum fruits for the treatment of non-melanoma skin cancer [100]. In order to promote skin permeation, different penetration enhancers were used and it was proven that 5% monoolein, alone or in combination with 10% ethanol, is most suitable to achieve permeation to the target site.…”

Section: Cellulose Derivatives As a Gelling Agentmentioning

confidence: 99%

Gel Formulations for Topical Treatment of Skin Cancer: A Review

Slavkova

Tzankov

Popova

et al. 2023

Gels

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Skin cancer, with all its variations, is the most common type of cancer worldwide. Chemotherapy by topical application is an attractive strategy because of the ease of application and non-invasiveness. At the same time, the delivery of antineoplastic agents through the skin is difficult because of their challenging physicochemical properties (solubility, ionization, molecular weight, melting point) and the barrier function of the stratum corneum. Various approaches have been applied in order to improve drug penetration, retention, and efficacy. This systematic review aims at identifying the most commonly used techniques for topical drug delivery by means of gel-based topical formulations in skin cancer treatment. The excipients used, the preparation approaches, and the methods characterizing gels are discussed in brief. The safety aspects are also highlighted. The combinatorial formulation of nanocarrier-loaded gels is also reviewed from the perspective of improving drug delivery characteristics. Some limitations and drawbacks in the identified strategies are also outlined and considered within the future scope of topical chemotherapy.

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In vitro and in vivo evaluation of the delivery of topical formulations containing glycoalkaloids of Solanum lycocarpum fruits

Cited by 16 publications

References 32 publications

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Bioactive Compounds Found in Brazilian Cerrado Fruits

Gel Formulations for Topical Treatment of Skin Cancer: A Review

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