In vitro and in vivo models to study the biological and pharmacological properties of queen bee acid (QBA, 10-hydroxy-2-decenoic acid): A systematic review

Paredes-Barquero, Marta; Niso-Santano, Mireia; Fuentes, José; Martínez-Chacón, Guadalupe

doi:10.1016/j.jff.2022.105143

Cited by 6 publications

(6 citation statements)

References 100 publications

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“…26) 10H2DA reportedly exerts a variety of biological and pharmacological activities, representing one of the main bioactive components of RJ. 27) Indeed, as does RJ, 10H2DA inhibits bone resorption in an ovariectomized murine model of osteoporosis, 14) improving glucose intolerance and insulin resistance in obese/diabetic mice. 28) Moreover, 10H2DA has not only anti-tumor, anti-angiogenic, and anti-biotic activities but anti-inflammatory activity in mammals.…”

Section: Discussionmentioning

confidence: 99%

“…28) Moreover, 10H2DA has not only anti-tumor, anti-angiogenic, and anti-biotic activities but anti-inflammatory activity in mammals. 27) Accordingly, 10H2DA could, at least in part, be implicated in the antiosteoarthritis property of RJ by inhibiting local inflammation in knee joints of a murine model of surgically-induced knee OA. Because raw RJ contains a variety of bioactive molecules besides 10H2DA, such as proteins, vitamins, and flavonoids, etc., further studies are warranted to determine the exact mechanism underlying its anti-osteoarthritis effect and to identify the additional components critical for this activity.…”

Section: Discussionmentioning

confidence: 99%

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Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly

Lyu

Kubo

Iwahashi

et al. 2023

Biological & Pharmaceutical Bulletin

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Royal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revealed that raw RJ significantly reduced the expression of inflammatory cytokines and enzymes critical for the degradation of the extracellular matrix (ECM). Similar results were observed after treatment with 10-hydroxy-2-decenoic acid, the most abundant and unique fatty acid in raw RJ. Our results suggest that oral supplementation with RJ would benefit the maintenance of joint health and prophylaxis against OA, possibly by suppressing the activity of inflammatory cytokines and ECM-degrading enzymes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly

Lyu

Kubo

Iwahashi

et al. 2023

Biological & Pharmaceutical Bulletin

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“…Also, this natural product has many vital biological properties that are beneficial such as antibacterial, anticancer, antitumor, and anti‐oxidant. In addition, it strengthens the immune system [14–18] . The physicochemical structure of RJ, major royal jelly proteins (MRJPs), 10‐hydroxy‐2‐decenoic acid (10‐HDA), and hormones play a role in the emergence of the beneficial properties of RJ solitary or with synergistic effects [19] …”

Section: Introductionmentioning

confidence: 99%

“…In addition, it strengthens the immune system. [14][15][16][17][18] The physicochemical structure of RJ, major royal jelly proteins (MRJPs), 10-hydroxy-2-decenoic acid (10-HDA), and hormones play a role in the emergence of the beneficial properties of RJ solitary or with synergistic effects. [19] RJ is a source of high-quality protein.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Study of the Physicochemical Properties of Royal Jelly from Various Regions of Türkiye**

Beykaya,

Inkaya,

Yorulmaz Onder

et al. 2023

Chemistry & Biodiversity

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This study analysed some physicochemical and quality parameters of 176 royal jelly (RJ) samples from different regions of Türkiye, collected over different years and seasons. According to the obtained results, the moisture percentage varied between 47.36% and 69.58%, with no statistically significant differences seen across various seasons and areas (p>0.05). The average value of 10‐hydroxy‐2‐decenoic acid (10‐HDA), which varies according to factors such as season, region, and year, was determined to be 2.32%. It was also seen that this value was close to the international standard. The values of total acidity ranged from 28–58 mL 1N NaOH/100 g. Furthermore, statistical significance (p<0.001) was observed for the year‐region interaction in relation to 10‐HDA and total acidity. The pH measurement results for all samples confirmed the acidic nature of the samples and resulted in a range between 3.45 and 3.80. And the pH variability was also found to be statistically significant for years (p=0.002) and regions (p=0.011). Finally, the correlation analysis between moisture (%), 10‐HDA (%), total acidity, and pH revealed no statistically significant or strong differences. This comprehensive study, supported by statistical analyses, is thought to be a useful reference for future research on RJ.

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“…Based on these findings, we hypothesized that the fatty acids in RJ might have bone-sparing effects after menopause. 10H2DA, also known as the queen bee acid, is the only fatty acid present exclusively in RJ and is regarded as the major indicator of RJ quality [ 18 ]. 10HDAA is the saturated counterpart of 10H2DA and is the second most abundant fatty acid in RJ.…”

Section: Introductionmentioning

confidence: 99%

Effects of 10-Hydroxy-2-decenoic Acid and 10-Hydroxydecanoic Acid in Royal Jelly on Bone Metabolism in Ovariectomized Rats: A Pilot Study

Hanai

Matsushita

Minami

et al. 2023

JCM

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Although previous studies have demonstrated that royal jelly (RJ) may have estrogenic properties and prevent postmenopausal bone loss, the underlying mechanisms are not fully understood. This animal study aimed to investigate the effects of specific fatty acids of RJ, 10-hydroxy-2-decenoic acid (10H2DA) and 10-hydroxydecanoic acid (10HDAA), in ovariectomized rats. Ten-week-old female Wistar rats were divided into the Baseline, Sham, Ovx, Ovx + 10H2DA, and Ovx + 10HDAA groups. Rats in the Baseline group were sacrificed immediately, whereas those in the other groups were subjected to either a sham operation or bilateral ovariectomy. The animals in the Ovx + 10H2DA and Ovx + 10HDAA groups were fed diets containing 10H2DA and 10HDAA, respectively. Twelve weeks after surgery, the rats were sacrificed, and indices of bone mass and bone mechanics were analyzed. Femoral bone mineral density was significantly lower in the Ovx group than in the Sham group (p < 0.01). Administration of 10H2DA or 10HDAA did not ameliorate bone loss after ovariectomy. In addition, administration of these fatty acids diminished femur bone stiffness in ovariectomized rats (p < 0.01 and p < 0.05, respectively). These findings suggest that the favorable effects of RJ may not be exerted solely by 10H2DA or 10HDAA. However, these effects may be exhibited in combination with other RJ constituents.

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In vitro and in vivo models to study the biological and pharmacological properties of queen bee acid (QBA, 10-hydroxy-2-decenoic acid): A systematic review

Cited by 6 publications

References 100 publications

Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly

Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly

Comprehensive Study of the Physicochemical Properties of Royal Jelly from Various Regions of Türkiye**

Effects of 10-Hydroxy-2-decenoic Acid and 10-Hydroxydecanoic Acid in Royal Jelly on Bone Metabolism in Ovariectomized Rats: A Pilot Study

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