In vitro and in vivo induction of chromosome aberrations by alpha- and beta-zearalenols: Comparison with zearalenone

Modified Fusarium mycotoxins unmasked: From occurrence in cereals to animal and human excretion

“…ZEN, α-and β-ZEL all induced chromosomal aberrations in a dose-dependent manner in mouse bone-marrow cells and in HeLa cells. β-ZEL was significantly less genotoxic compared to ZEN and α-ZEL, who had a comparable genotoxic profile (Ayed et al, 2011). A more toxic effect of α-ZEL compared to β-ZEL has been described for the proliferation of human breast cancer cell lines, the degeneration of porcine oocytes and embryos, and the viability of boar spermatozoa (Alm et al, 2002;Benzoni et al, 2008;Minervini et al, 2005).…”

Detoxification of zearalenone by three strains of lactobacillus plantarum from fermented food in vitro

“…ZEA and some of its derivatives are considered endocrine disrupters, and can cause estrogenic effects, alter reproduction and induce genotoxic effects by induction of DNA adducts, DNA fragmentation, apoptosis, micronuclei and chromosome aberrations (Abid-Essefi et al, 2003;Ayed, Ayed-Boussema, Ouanes, & Bacha, 2011;Diekman & Green, 1992;Ouanes, Ayed-Boussema, Baati, Creppy, & Bacha, 2005). ZEA occurs naturally in many important crops worldwide, such as maize, barley, oats, wheat, rice, sorghum, and rye with high concentrations (Zinedine, Soriano, Molt o, & Mañes, 2007).…”

Human exposure to mycotoxins and their masked forms through cereal-based foods in Belgium

“…Concerning masked ZEN-forms Ayed et al (2011) argued that ZEN and α-ZEL exhibited the same range of cytotoxicity and genotoxicity, and both were more cyto-and genotoxic than β-ZEL. Recently, a study was executed on the amount of these forms in rats (Versilovskis et al, 2012).…”