In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver

Gerbron, Marie; Geraudie, Perrine; Xuereb, Benoît; Marie, Sabine; Minier, Christophe

doi:10.1016/j.marpolbul.2015.03.043

Cited by 6 publications

(2 citation statements)

References 62 publications

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“…Egg yolk related proteins and associated gene expression have been recently shown to decrease after exposure to heavy metals (Gerbron et al 2015). The precise underlying mechanism resulting in the variation of expression of those transcripts is unclear because of the ongoing debate surrounding the presence and/or function of steroid hormones in bivalves Figure 5.…”

Section: Histological Analysismentioning

confidence: 99%

Impact of Metformin and Increased Temperature on Blue Mussels Mytilus edulis - Evidence for Synergism

Koagouw

Ciocan

2018

Journal of Shellfish Research

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The capability of selected pharmaceuticals to act as nontraditional endocrine disrupting chemicals in the environment has been poorly documented. The widely prescribed antidiabetic metformin has the potential to accumulate and persist in water bodies, with unknown consequences for aquatic biota. This study reports the biological responses of a sentinel organism, common mussel Mytilus edulis, exposed to concentrations of metformin commonly found in the aquatic environment, coupled with heat stress. The results indicate that metformin has the potential to increase the vitellogenin mRNA expression, to inflict severe pathologies of the gonad and to destabilize the lysosomal membrane in the hemocytes. Overall, this article suggests that metformin should be considered an emerging contaminant of concern and further research should focus on its mechanisms of action.

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Section: Histological Analysismentioning

confidence: 99%

Impact of Metformin and Increased Temperature on Blue Mussels Mytilus edulis - Evidence for Synergism

Koagouw

Ciocan

2018

Journal of Shellfish Research

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“…Non-essential metals like Cd can cause deleterious effects on biota even at low concentrations (Satarug et al, 2009). Although the concentration of Cd was below the established level set by the Brazilian legislation, Cd is a human carcinogen, a potent endocrine disruptor, and exerts toxic effects on kidney, skeletal, respiratory, and reproductive systems (Gerbron et al 2015;Jiménez-Ortega et al 2012;Wang et al 2014;WHO 2011). Mn and Pb can inhibit AchE (Santos et al 2012), and mixtures of Pb + Cd (detected in SC) can induce neuronal degeneration in the brain even at low concentrations (Cobbina et al 2015).…”

Section: Physicochemical Parameters Are Not Enough To Predict the Chementioning

confidence: 99%

Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil)

Yamamoto

Pereira

Lottermann

et al. 2016

Environ Sci Pollut Res

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The Iguaçu River, located at the Southern part of Brazil, has a great socioeconomic and environmental importance due to its high endemic fish fauna and its potential to generate hydroelectric power. However, Iguaçu River suffers intense discharge of pollutants in the origin of the river. In a previous report, the local environmental agency described water quality to improve along the river course. However, no study with integrated evaluation of chemical analysis and biological responses has been reported so far for the Iguaçu River. In the current study, three different Brazilian fish species (Astyanax bifasciatus, Chrenicicla iguassuensis, and Geophagus brasiliensis) were captured in the five cascading reservoirs of Iguaçu River for a multi-biomarker study. Chemical analysis in water, sediment, and muscle indicated high levels of bioavailable metals in all reservoirs. Polycyclic aromatic hydrocarbons (PAHs) were detected in the bile of the three fish species. Integration of the data through a FA/PCA analysis demonstrated the poorest environmental quality of the reservoir farthest from river's source, which is the opposite of what has been reported by the environmental agency. The presence of hazardous chemicals in the five reservoirs of Iguaçu River, their bioaccumulation in the muscle of fish, and the biological responses showed the impacts of human activities to this area and did not confirm a gradient of pollution between the five reservoirs, from the source toward Iguaçu River's mouth. Therefore, diffuse source of pollutants present along the river course are increasing the risk of exposure to biota and human populations.

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Analysis of vitellogenin by histochemical method as an indicator of estrogenic effect in male Danio rerio exposed to metals

Alkimin

Fracácio

2020

Environ Sci Pollut Res

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In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver

Cited by 6 publications

References 62 publications

Impact of Metformin and Increased Temperature on Blue Mussels Mytilus edulis - Evidence for Synergism

Impact of Metformin and Increased Temperature on Blue Mussels Mytilus edulis - Evidence for Synergism

Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil)

Analysis of vitellogenin by histochemical method as an indicator of estrogenic effect in male Danio rerio exposed to metals

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