In vitro and in vivo evaluation of antioxidant activity of Annona muricata stem bark extracts in Rattus norvegicus

Omale, J; Sanni, Olakunle

doi:10.1055/s-0035-1565710

Cited by 2 publications

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“…Graviola fruit, roots and leaves used as juice, tea or other solutions, have been important part of traditional medicine and remedies throughout the world [3]. For instance, the Graviola leaves and seeds extract have been used to treat liver problems, fever, and inflammations, along with the fruit have been used as anticancer, anti-diabetic and antihypertensive [3,4]. Graviola fruit is rich in bioactive compounds such an alkaloid, flavonoid and phenols and is known to possess antioxidant capacity in which it plays an important role in prevention of oxidative stress-mediated human chronic diseases [5,6].…”

Section: Introductionmentioning

confidence: 99%

Phytonutrients Potential Properties of Graviola Leaves Extract

Waly¹

2018

OAJAR

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Recent studies indicated that regular consumption of antioxidant rich foods reduce cellular oxidative stress and protect against health related problems. Annona muricata, is a tropical fruit, commonly known as Graviola, which has been identified as a rich source of bioactive compounds and is considered as an integral part of folklore medicine. The use of Graviola leaves as a therapeutic agent is recently accelerated, yet there is scarce scientific evidence justifying its use. This study aimed to assess the in vitro antioxidant properties and phytonutrients content of the Omani cultivated Graviola leaves. Our study revealed that Graviola leaves extract is rich in phytonutrients content (The total phenolic content was 16.82 mg Gallic acid equivalent (GAE)/g dry solid and the total flavonoid content was 7.79 mg Catechin equivalent (CE)/ g dry solid) and acted as a potent free radical scavenger and provided protection against H2O2-induced oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Phytonutrients Potential Properties of Graviola Leaves Extract

Waly¹

2018

OAJAR

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Effect of Annona Muricata L. on Metabolic Parameters in Diabetes Mellitus: A Systematic Review

Alwan

Lim

Samad

et al. 2020

Curr Res Nutr Food Sci

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In recent decades, numerous scientific investigations have been conducted to study the antidiabetic effects of Annona muricata L. However, no comprehensive evidence-based systematic review regarding this topic is available. Hence, this study was conducted to systematically evaluate the studies of the efficacy of A. muricata in diabetes management. Six online databases used to search for the related articles. The search terms used were A. muricata/ soursop in combination with diabetes, glucose, and insulin. Seventeen studies were identified that fit the inclusion criteria (1 clinical, 10 in vivo, 4 in vitro, 1 in vivo/ in vitro and 1 in silico). A clinical study showed the positive adjuvant effect of A. muricata to glibenclamide in type 2 diabetes patients. In vivo studies reported beneficial effects of A. muricata in murine models to include decreasing fasting blood glucose level, attenuating diabetes-associated weight loss, increasing serum insulin, improving the lipid profile, normalizing the activity of antioxidant enzymes, and exerting pancreas-protective and hepatoprotective effects. In vitro studies of A. muricata demonstrated its potential for reducing post-prandial glucose level by inhibiting pancreatic α-amylase, lipase, and α-glucosidase and lowering oxidative stress by inhibiting glycation and lipid peroxidation. Additionally, the in-silico study suggested a positive effect of A. muricata in enhancing insulin sensitivity. A. muricata showed a promising effect on the metabolic parameters in diabetes mellitus. Considering that A. muricata is widely consumed worldwide, further exploration of its therapeutic potential is worthwhile.

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In vitro and in vivo evaluation of antioxidant activity of Annona muricata stem bark extracts in Rattus norvegicus

Cited by 2 publications

References 0 publications

Phytonutrients Potential Properties of Graviola Leaves Extract

Phytonutrients Potential Properties of Graviola Leaves Extract

Effect of Annona Muricata L. on Metabolic Parameters in Diabetes Mellitus: A Systematic Review

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