In vitro and in vivo degradation behaviors of synthetic absorbable bicomponent monofilament suture prepared with poly(p-dioxanone) and its copolymer

Im, Jung Nam; Kim, Jeong Kyung; Kim, Hyun-Kyoon; In, Chang Hoon; Lee, Kuen Yong; Park, Won Ho

doi:10.1016/j.polymdegradstab.2006.12.011

Cited by 55 publications

(34 citation statements)

References 22 publications

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“…PDO has shown excellent biocompatibility in applications such as sutures , orthopedic tissue fixation devices , and chest wall prosthesis . In the vasculature, PDO has been tested as vascular grafts , stents , and valved patches , and has shown good biocompatibility and minimal thrombosis.…”

Section: Discussionmentioning

confidence: 99%

“…PDO adopts a two‐stage degradation mechanism . At the initial stage (up to 6–8 weeks), degradation occurs at the surface with minimal changes in the mass, and about 50% of the original strength remained after 6 weeks post‐implantation . Zilberman et al reported that PDO and PLLA stents can afford good support for 5 and 24 weeks in vitro degradation, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Development and preclinical evaluation of a biodegradable ventricular septal defect occluder

Huang

Zhu

Cao

et al. 2012

Cathet Cardio Intervent

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development and preclinical evaluation of a biodegradable ventricular septal defect occluder

Huang

Zhu

Cao

et al. 2012

Cathet Cardio Intervent

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show abstract

“…The presence of an ether bond and an additional -CH 2 -in its molecular structure give polydioxanone more flexibility than PGA or PLLA. Polydioxanone and its copolymer materials (MonoFlex 1 ) have shown a reduction of $50% of strength between 4 and 6 weeks in vivo and bioabsorbed in about 6 months with minimal tissue reactions (Im et al, 2007). Tubular scaffolds of electrospun polydioxanone/ elastin having tensile properties matching to those of femoral artery were reported by Sell et al (2006).…”

Section: Introductionmentioning

confidence: 95%

A biomimetic tubular scaffold with spatially designed nanofibers of protein/PDS® bio‐blends

Thomas

Zhang

Vohra

2009

Biotech & Bioengineering

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Electrospun tubular conduit (4 mm inner diameter) based on blends of polydioxanone (PDS II(R)) and proteins such as gelatin and elastin having a spatially designed trilayer structure was prepared for arterial scaffolds. SEM analysis of scaffolds showed random nanofibrous morphology and well-interconnected pore network. Due to protein blending, the fiber diameter was reduced from 800-950 nm range to 300-500 nm range. Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) results confirmed the blended composition and crystallinity of fibers. Pure PDS scaffold under hydrated state exhibited a tensile strength of 5.61 +/- 0.42 MPa and a modulus of 17.11 +/- 1.13 MPa with a failure strain of 216.7 +/- 13%. The blending of PDS with elastin and gelatin has decreased the tensile properties. A trilayer tubular scaffold was fabricated by sequential electrospinning of blends of elastin/gelatin, PDS/elastin/gelatin, and PDS/gelatin (EG/PEG/PG) to mimic the complex matrix structure of native arteries. Under hydrated state, the trilayer conduit exhibited tensile properties (tensile strength of 1.77 +/- 0.2 MPa and elastic modulus of 5.74 +/- 3 MPa with a failure strain of 75.08 +/- 10%) comparable to those of native arteries. In vitro degradation studies for up to 30 days showed about 40% mass loss and increase in crystallinity due to the removal of proteins and "cleavage-induced crystallization" of PDS.

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“…The dorsal side of the rats was shaved and disinfected with 75% alcohol for surgery. Sterile multifilament DAC suture (USP 2‐0), 10 cm in length, was implanted by sewing with a long needle (8 cm) inserting through the left dorsal subcutis of each rat . Treated with Vicryl® Plus suture (USP 2‐0) in the right dorsal subcutis was employed as control.…”

Section: Methodsmentioning

confidence: 99%

Fabrication and feasibility study of an absorbable diacetyl chitin surgical suture for wound healing

et al. 2015

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Diacetyl chitin (DAC) is an acidylated chitin obtained using acetic anhydride mixed perchloric acid system. By wet spinning and weaving technique, DAC has been successfully developed into a novel absorbable surgical suture. Thanks to the unique properties of chitins, the potential application of this novel monocomponent multifilament DAC suture may break the monopoly of synthetic polymer sutures in wound closure area. In this study, DAC was synthesized and characterized by multiple approaches including elemental analysis, Fourier transform infrared spectrometry (FTIR), and X-ray diffraction (XRD). In addition, we performed the feasibility assessment of DAC suture (USP 2-0) as absorbable suture for wound healing. Several lines of evidences suggested that DAC suture had comparable mechanical properties as synthetic polymer sutures. Moreover, DAC suture retained approximately 63% of the original strength at 14 days and completely absorbed in 42 days with no remarkable tissue reaction in vivo. Most important of all, DAC suture significantly promoted skin regeneration with faster tissue reconstruction and higher wound breaking strength on a linear incisional wound model. All these results demonstrated the potential use of DAC suture in short- or middle-term wound healing, such as epithelial and connective tissue.

show abstract

In vitro and in vivo degradation behaviors of synthetic absorbable bicomponent monofilament suture prepared with poly(p-dioxanone) and its copolymer

Cited by 55 publications

References 22 publications

Development and preclinical evaluation of a biodegradable ventricular septal defect occluder

Development and preclinical evaluation of a biodegradable ventricular septal defect occluder

A biomimetic tubular scaffold with spatially designed nanofibers of protein/PDS® bio‐blends

Fabrication and feasibility study of an absorbable diacetyl chitin surgical suture for wound healing

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