In-Vitro and In-Vivo Pathogenicity Study of Cryptococcus Species

Banerjee, Amitav; Pradhan, Saktipada; Debnath, Chanchal; Baidya, S.; Patra, Nimai Chand; Hansda, Rabindra Nath; Mondal, Samiran; Mukhopadhayay, S. K.

doi:10.20546/ijcmas.2017.612.290

Cited by 1 publication

(1 citation statement)

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“…Design for experimental infection in animals was done as was described by Banerjee et al (2017), Pedroso et al (2009), Known Chung et al (1992 and Nishimura and Miyaji (1979) with slight modifications. After acclimatizing the experimental animals for about one week, animals were assigned into four groups: GroupI and Gr II consisted of 13 numbers of mice each, injected with infective inocula of Papiliotrema laurentii (MT102623) and reference sample Papiliotrema laurentii (MTCC 2898) respectively.…”

Section: Animal Study and Infectious Challengementioning

confidence: 99%

Experimental Pathogenicity of Papiliotrema laurentii in Swiss Albino Mice

Islam,

Bharali,

Sarma

et al. 2023

IJVPH

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Cryptococcus may be found as pathogenic fungi which have rarely been studied. In this study the virulence factor of non-neoformans Cryptococcus species, biological characteristics of the fungal pathogen and pathophysiology of mice infected with the Cryptococcal species Papiliotrema laurentii compared with normal mice for definite time intervals. All the test mice were inoculated with the yeast cells of cryptococcal organisms that showed an almost uniform pattern of behavior in relation to the isolation of the same specific organisms from different organs of the infected mice during the interval of the experimental period. Tissue samples were studied after processing from the both dead and also from the mice scarified on the scheduled day of post infection except from those of the control group. The yeast cells were cultured following standard protocol and the biological characteristics were also studied. The pathogenicity of nonneoformans species of the genus did not show much pathogenicity in mice. The findings of the present study also indicated that the cultural and biochemical characteristics and, also pathophysiology of the species Papiliotrema laurenti in mice. However, No recovery of Papiliotrema laurentii was observed from any organs on this specific day of post infection with this organism i.e. Papiliotrema laurentii which made the study a significant observation. The pathogenic effects of this species were not the same in different time intervals. This reflects that virulence factors are related to time intervals in mice infection regimens before isolation from organs. Histopathological findings also were found from liver and brain. As Cryptococcosis a zoonotic disease, study of virulence factors of the organisms in mice modal may help in understanding the transmission of this disease and its pathogenicity.

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Section: Animal Study and Infectious Challengementioning

confidence: 99%