In vitro and in vivo activities of polyphenol extracts from Arctic brown alga Fucus vesiculosus

Боголицын, К. Г.; Добродеева, Л. К.; Паршина, А. Э.; Самодова, А. В.

doi:10.1007/s10811-021-02450-y

Cited by 6 publications

(3 citation statements)

References 65 publications

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“…Eckol from Ecklonia species was reported to stimulate cytokines, phagocytosis, dendritic cells, and T-lymphocytes thereby increasing the activity of immune responses [56]. According to the data given by Bogolitsyn et al [57], polyphenols extracted from F. vesiculosus on tested in outbred white mice showed a potential immune modulation effect. They stimulated phagocytosis by evaluating the act of erythrocytes, neutrophils, and lymphocytes without damaging the cell membrane.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Comprehensive reviews on phenolic compounds from Phaeophyceae as potential therapeutic agent

Maheswari¹,

Babu²

2022

J App Biol biotech

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Seaweeds are an excellent source of natural bioactive compounds. The exploration of novel natural compounds from marine resources has gained interest lately which possesses greater pharmaceutical and nutritional values. Seaweed phenolic compounds, particularly phlorotannin, have been discovered to have a variety of biological implications. Phlorotannin is a polyphenol that is found majorly in brown seaweed and is made up of polymeric units of phloroglucinol. The structural configuration and degree of polymerization were shown to influence biological activity. Several in vitro studies demonstrated that the phlorotannin derivatives had substantial bioactivity and were moderately appraised in vivo. Antioxidant, anticancer, anti-inflammatory, anti-allergic, anti-diabetic, and anti-microbial effects have been discovered in phlorotannin compounds. Recently, they have been evaluated for exhibiting anti-viral capacity against various harmful viruses. The findings suggested that phlorotannin could be an effective anti-viral molecule that requires intense research. This review focuses on the advanced techniques and research based on the experiments on phlorotannin for their extraction and purification. The phlorotannin as a potential drug molecule has been described from extraction to application. With the advent of technology, it is now possible to isolate the target molecule efficiently in less time. To make phlorotannin a novel nutraceutical and pharmaceutical molecule with wide industrial uses, preclinical and clinical research is required to assess its efficacy, toxicity, bioavailability, and drug delivery mechanism.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Comprehensive reviews on phenolic compounds from Phaeophyceae as potential therapeutic agent

Maheswari¹,

Babu²

2022

J App Biol biotech

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“…The enhancement of phagocytosis in human blood leukocytes was achieved via polyphenols from Fucus vesiculosus. The polyphenols were tested in vivo in outbred white mice by injecting intra-peritoneally, at the concentration of 5pg/ml with 1 mL saline, which were found to establish immune modulation [12]. In addition, dieckol from Ecklonia cava exhibited in PC12 cells effective anti-inflammatory activity by reducing the activity of p38, Extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinases (JNK).…”

Section: Immunomodulating Activity For Inhibiting Viral Growthmentioning

confidence: 99%

Phlorotannin and its Derivatives, a Potential Antiviral Molecule from Brown Seaweeds, an Overview

Maheswari

Babu

2022

Russ J Mar Biol

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Research on seaweeds provides a continual discovery of natural bioactive compounds. The review presents new information on studies of the potential and specific antiviral action of phlorotannin and their derivatives from marine brown algae. Phlorotannin is a polyphenolic derivative and a secondary metabolite from marine brown algae which exhibits a high quality of biological properties. Phlorotannin has a variety of biological activities that include antioxidant, anticancer, antiviral, anti-diabetic, anti-allergic, antibacterial, antihypertensive and immune modulating activities. These phlorotannin properties were revealed by various biochemical and cell-based assays in vitro. This distinctive polyphenol from the marine brown algae may be a potential pharmaceutical and nutraceutical compound. In this review, the extraction, quantification, characterization, purification, and biological applications of phlorotannin are discussed, and antiviral potential is described in detail.

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“…Вопросам изучения водорослей уделяется большое внимание в связи с доказанной медико-биологической активностью, проявляемой их экстрактами [8]. Установлено, что они обладают антибактериальным и противовирусным эффектами [9].…”

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Chemical composition of seaweed and its medical-biological properties

Gorbachev,

Kubasov

2023

Marine Medicine

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RELEVANCE. Seaweed, along with all the other aquatic biological resources, is of great economic importance for all countries of the world community. Due to positive effects of biologically active substances, contained therein, it is widely used as dietary supplements, drugs, hydrocolloids (agar, alginates, carrageenan). OBJECTIVE. Based on literature data to study current knowledge about the chemical composition of seaweed and its medical-biological properties, which can be used in life activity. MATERIALS AND METHODS. The study used literature sources from international databases Web of Science, Scopus as well as the national library system eLibrary. The keywords in the search engine: seaweed, biochemical composition, biologically active properties, medical importance. RESULTS. The chemical composition of seaweed is due to its habitat. It contains practically all chemical elements, present in seawater. Because of beneficial biological effects, seaweed is widely used by humans, especially in medicine. Among organic compounds seaweed is rich in polysaccharides, lipids, protein compounds as well as vitamins. The main part of polysaccharides belongs to alginic acid and fucoidan. Alginates have anti-inflammatory, sorption and reparative properties, normalize metabolism. Fucoidans have anticoagulant and antioxidant effect, inhibit penetration of viruses into tissue cells. DISCUSSION. Seaweed is rich in protein compounds. It contains all essential amino acids. Moreover, all classes of fatty acid (especially polyunsaturated) are found in seaweed. Lastly, many water-soluble and fat-soluble vitamins are synthesized in seaweed, like plants on land: ascorbic acid, tocopherols, carotenes, thiamine, cobalamins, etc. It is concluded that seaweed can be considered a unique supplier of biologically active components: minerals, proteins, polysaccharides, polyunsaturated fats and vitamins. Its use is justified with therapeutic and preventive purposes.

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In vitro and in vivo activities of polyphenol extracts from Arctic brown alga Fucus vesiculosus

Cited by 6 publications

References 65 publications

Comprehensive reviews on phenolic compounds from Phaeophyceae as potential therapeutic agent

Comprehensive reviews on phenolic compounds from Phaeophyceae as potential therapeutic agent

Phlorotannin and its Derivatives, a Potential Antiviral Molecule from Brown Seaweeds, an Overview

Chemical composition of seaweed and its medical-biological properties

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