In Vitro and In Vivo Anti-Psoriasis Activity of Ficus carica Fruit Extracts via JAK-STAT Modulation

Lee, Jeong Hwa; Lee, Mi-Young

doi:10.3390/life13081671

Cited by 4 publications

(2 citation statements)

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“…The results showed that the extract reduced nitric oxide production, and iNOS and COX-2 expression in inflammatory-activated cells significantly influenced the JAK-STAT signaling pathway associated with psoriasis and reduced the release of β-hexosaminidase. In mice, extract treatment decreased skin thickness and PASI score, and decreased epidermal dermis thickness, in addition to reducing STAT3 phosphorylation, all of which demonstrate that FC fruit extract may be a potential therapeutic agent for psoriasis [100].…”

Section: Ficus Carica In Psoriazismentioning

confidence: 80%

Natural Sources of Therapeutic Agents Used in Skin Conditions

Dinu,

Tatu,

Cocoș

et al. 2024

Life

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Skin conditions are numerous and often have a major impact on patients’ quality of life, and effective and safe treatment is very important. The conventional drugs used for skin diseases are usually corticosteroids and antimicrobial products that can induce various side effects, especially with long-term use, which is why researchers are studying alternatives, especially biologically active natural products. Three products caught our attention: bee venom (BV), due to reported experimental results showing anti-inflammatory, antibacterial, antiviral, antioxidant, antimycotic, and anticancer effects, Ficus carica (FC) due to its demonstrated antioxidant, antibacterial, and anti-inflammatory action, and finally Geranium essential oil (GEO), with proven antifungal, antibacterial, anti-inflammatory, and antioxidant effects. Following a review of the literature, we produced this paper, which presents a review of the potential therapeutic applications of the three products in combating various skin conditions and for skin care, because BV, FC, and GEO have common pharmacological actions (anti-inflammatory, antibacterial, and antioxidant). We also focused on studying the safety of the topical use of BV, FC, and GEO, and new approaches to this. This paper presents the use of these natural therapeutic agents to treat patients with conditions such as vitiligo, melasma, and melanoma, as well as their use in treating dermatological conditions in patients with diabetes.

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Section: Ficus Carica In Psoriazismentioning

confidence: 80%

Natural Sources of Therapeutic Agents Used in Skin Conditions

Dinu,

Tatu,

Cocoș

et al. 2024

Life

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“…Here in the survey, mice treated with S. deserti methanolic extract harboured lower levels of cytokines compared to the control group. Similarly, Ficus carica [29], and Dysidea avara [30] extracts showed high anti-psoriasis effects through the reduction in rates of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 98%

Assessment of the anti-psoriasis effect of Scrophularia deserti methanolic extract in mice model

Khaleel,

Shareef,

Maryoosh

2024

SR: PS

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Psoriasis is an underestimated chronic and autoimmune skin disorder. Topical chemical agents are applied for psoriasis control and treatment, notwithstanding their subordinate efficiency or unsuccessful activities. As an alternative, herbal medicine can also be used in its treatment. The aim of the present study was performed to assess the anti-psoriasis effect of Scrophularia deserti in mice model. Materials and methods: S. deserti was purchased and used for methanolic extraction. Extract DPPH radical scavenging activity, polyphenol and flavonoid contents were examined. Sixty male mice were purchased, and psoriasis was induced using 10 days of topical administration of Imiquimod (62.5 mg). Mice were classified into 6 groups: non-psoriasis control (only received distilled water), psoriasis control (only received topical Imiquimod), two S. deserti treatments (topical 300 and 500 mg/kg), topical Betamethasone, and topical α-pinene 9 %. Cytokine distribution and histopathological properties were also determined. Results: the value at which the S. deserti methanolic extract scavenges 50 % of free radicals (IC50) was 602.71±15.33 µg/mL. The total S. deserti methanolic extract flavonoid and polyphenol contents were 16.85±1.12 mg QE/g and 58.47±3.25 mg GAE/g, respectively. IL-22, TNF-α, and IL-17A concentrations increased after psoriasis induction compared to the control group (P <0.05). Mice treated with Betamethasone harboured the lowest concentrations of IL-22, TNF-α, and IL-17A (P <0.05). Conclusions: Mice treated with S. deserti methanolic extract (500 mg/kg) also harboured significantly lower IL-22, TNF-α, and IL-17A (P <0.05) compared to α-pinene and S. deserti methanolic extract (300 mg/kg). Mice of the psoriasis control group showed significant epidermis hyperkeratosis, acanthosis, and crust with plentiful inflammatory cells. At the same time, mice treated with S. deserti methanolic extract (500 mg/kg) showed significant recovered tissue with normal skin epidermis and dermis, sebaceous glands, and follicles of the hair, besides the lowest rate of inflammatory reactions. Findings showed that the S. deserti methanolic extract (500 mg/kg) can efficiently be used as a practical substitute for psoriasis treatment. However, some supplementary research should be performed

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Research progress on the pathogenesis of psoriasis and its small molecule inhibitors

Xia,

Li,

Long

et al. 2024

Archiv der Pharmazie

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Psoriasis is a prevalent chronic systemic immune disease characterized by T‐cellmediated hyperproliferation of keratinized cells. Among its various manifestations, plaque‐type psoriasis is the most common. Treatment options for psoriasis encompass topical medications, biological therapies, phototherapy techniques, and others. However, traditional treatments are associated with numerous side effects. In contrast, targeted therapy has garnered increasing attention due to its high selectivity, strong safety profile, and favorable therapeutic outcomes. Patients with psoriasis lesions exhibit elevated levels of proinflammatory cytokines compared with the general population. These proinflammatory cytokines have been implicated in mediating psoriasis pathogenesis by inducing keratinocyte proliferation through multiple signaling pathways within the body. This study will delve into the Janus kinase‐signal transducers and activators of transcription, phosphatidylinositol 3 kinase (PI3K)‐protein kinase B (PKB, also known as AKT), and nuclear factor Kappa‐light‐chain‐enhancer of activated B cells signaling pathways to elucidate their roles in mediating psoriasis pathogenesis. In addition, we will summarize potential targets relevant to the treatment of psoriasis and discuss the design and activity assessment of their inhibitors. It also provides new insights for further in‐depth study of psoriasis and development of novel molecularly targeted inhibitors.

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In Vitro and In Vivo Anti-Psoriasis Activity of Ficus carica Fruit Extracts via JAK-STAT Modulation

Cited by 4 publications

References 50 publications

Natural Sources of Therapeutic Agents Used in Skin Conditions

Natural Sources of Therapeutic Agents Used in Skin Conditions

Assessment of the anti-psoriasis effect of Scrophularia deserti methanolic extract in mice model

Research progress on the pathogenesis of psoriasis and its small molecule inhibitors

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