In vitro and in vivo evaluation of cyclosporine-graphene oxide laden hydrogel contact lenses

Desai, Ditixa T.; Maulvi, Furqan A.; Desai, Ankita R.; Shukla, Manish; Desai, Bhargavi V.; Khadela, Avinash; Shetty, Kiran H.; Shah, Dinesh O.; Willcox, Mark

doi:10.1016/j.ijpharm.2021.121414

Cited by 17 publications

(7 citation statements)

References 42 publications

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“…A lens with high water retention may be more flexible and conformable to the shape of the eye, which can improve comfort for the wearer. [ 40 ] BAu and TAu lenses exhibit lower water retention compared to plain lenses. This might be due to the occupation of Au NPs on the contact lenses’ interstitial space, which reduced its ability to absorb water.…”

Section: Resultsmentioning

confidence: 99%

Biogenic Gold Nanoparticle‐Based Antibacterial Contact Lenses for Color Blindness Management

Jacob,

Syed,

Cherumkuzhi

et al. 2024

Adv Eng Mater

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Biogenic gold nanoparticles synthesized using olive leaf extract were used as an additive in commercial contact lenses (BAu lens). Their antibacterial and colorblindness‐correcting properties were examined. To compare the properties, gold nanocomposite contact lenses were also synthesized using the well‐known Turkevich method (TAu lens). The breath in/breath out method was used to load the gold nanoparticles onto commercial contact lenses. The bio‐gold nanoparticles showed good dispersion and stability within the lens hydrogel matrix. Nanoparticle loading had a negligible effect on the contact lenses’ wettability and swelling properties. BAu lens filtered around 55% of visible light at 530 nm, a problematic wavelength for colorblind patients. The optical filtering results were comparable with Pilestone commercial colorblind correction glasses. BAu lenses also showed superior resistance against the attack of Pseudomonas aeruginosa and Staphylococcus aureus bacteria as compared to Tau lenses. As SEM imaging showed, the BAu lenses showed a complete lack of surface attachment toward the bacterial colonies. This research provides a cost‐effective and scalable method of producing multi‐functional nanocomposite contact lenses with antibacterial and colorblind correction properties.This article is protected by copyright. All rights reserved.

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Section: Resultsmentioning

confidence: 99%

Biogenic Gold Nanoparticle‐Based Antibacterial Contact Lenses for Color Blindness Management

Jacob,

Syed,

Cherumkuzhi

et al. 2024

Adv Eng Mater

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“…In a study conducted by Desai and colleagues in 2022, they observed a decrease in MMP9 intensity in the right eyes treated with CsA/C-HA micelle contact lenses and eye drops compared to the control group in the left eyes. Moreover, rabbits exhibited swift recovery from DED when using a graphene contact lens loaded with CsA, ensuring a continuous high concentration of CsA in the corneal fluid [155].…”

Section: Contact Lens-based Drug Delivery For Dedmentioning

confidence: 99%

Current Advances in Regenerative Strategies for Dry Eye Diseases: A Comprehensive Review

Bhujel,

Oh,

Kim

et al. 2023

Bioengineering

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Dry eye disease (DED) is an emerging health issue affecting millions of individuals annually. Ocular surface disorders, such as DED, are characterized by inflammation triggered by various factors. This condition can lead to tear deficiencies, resulting in the desiccation of the ocular surface, corneal ulceration/perforation, increased susceptibility to infections, and a higher risk of severe visual impairment and blindness. Currently, the clinical management of DED primarily relies on supportive and palliative measures, including the frequent and lifelong use of different lubricating agents. While some advancements like punctal plugs, non-steroidal anti-inflammatory drugs, and salivary gland autografts have been attempted, they have shown limited effectiveness. Recently, there have been promising developments in the treatment of DED, including biomaterials such as nano-systems, hydrogels, and contact lenses for drug delivery, cell-based therapies, biological approaches, and tissue-based regenerative therapy. This article specifically explores the different strategies reported so far for treating DED. The aim is to discuss their potential as long-term cures for DED while also considering the factors that limit their feasibility and effectiveness. These advancements offer hope for more effective and sustainable treatment options in the future.

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“…Desai et al (2021) developed a contact lens with graphene oxide to incorporate the hydrophobic drug CsA by the soaking method and evaluated its in vitro drug release. They demonstrated that the increased drug uptake did not change the optical or swelling characteristics [ 104 ].…”

Section: Treatments Of Dry Eye Diseasementioning

confidence: 99%

“…A decrease in the MMP9 intensity was observed for the right eyes (OD) treated with eye drops and CsA/C-HA micelle CL compared to control group (OS). Desai et al (2022) observed that rabbits recovered quickly from DED with a CsA graphene contact lens and a higher amount of CsA in the corneal fluid for a long time [ 104 ].…”

Section: Treatments Of Dry Eye Diseasementioning

confidence: 99%

A Review on Dry Eye Disease Treatment: Recent Progress, Diagnostics, and Future Perspectives

et al. 2023

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Dry eye disease is a multifactorial disorder of the eye and tear film with potential damage to the ocular surface. Various treatment approaches for this disorder aim to alleviate disease symptoms and restore the normal ophthalmic environment. The most widely used dosage form is eye drops of different drugs with 5% bioavailability. The use of contact lenses to deliver drugs increases bioavailability by up to 50%. Cyclosporin A is a hydrophobic drug loaded onto contact lenses to treat dry eye disease with significant improvement. The tear is a source of vital biomarkers for various systemic and ocular disorders. Several biomarkers related to dry eye disease have been identified. Contact lens sensing technology has become sufficiently advanced to detect specific biomarkers and predict disease conditions accurately. This review focuses on dry eye disease treatment with cyclosporin A-loaded contact lenses, contact lens biosensors for ocular biomarkers of dry eye disease, and the possibility of integrating sensors in therapeutic contact lenses.

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In vitro and in vivo evaluation of cyclosporine-graphene oxide laden hydrogel contact lenses

Cited by 17 publications

References 42 publications

Biogenic Gold Nanoparticle‐Based Antibacterial Contact Lenses for Color Blindness Management

Biogenic Gold Nanoparticle‐Based Antibacterial Contact Lenses for Color Blindness Management

Current Advances in Regenerative Strategies for Dry Eye Diseases: A Comprehensive Review

A Review on Dry Eye Disease Treatment: Recent Progress, Diagnostics, and Future Perspectives

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