2016
DOI: 10.1007/s11095-016-1964-7
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In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano™ Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs

Abstract: PCC can continuously produce nanoparticle APIs and is an efficient approach for improving their oral bioavailability.

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Cited by 15 publications
(7 citation statements)
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“…Moreover, no miconazole nanoparticles could be obtained with the conventional batch method. As expected, the smaller particle size led to the faster dissolution rates of drug molecules (Figure 7b), and therefore, to higher plasma concentrations after oral administration (Figure 7c) [106].…”
Section: Drug Nanosuspensionssupporting
confidence: 74%
See 1 more Smart Citation
“…Moreover, no miconazole nanoparticles could be obtained with the conventional batch method. As expected, the smaller particle size led to the faster dissolution rates of drug molecules (Figure 7b), and therefore, to higher plasma concentrations after oral administration (Figure 7c) [106].…”
Section: Drug Nanosuspensionssupporting
confidence: 74%
“…200 nm. Moreover, phenytoin, bezafibrate, flurbiprofen, and miconazole nanocrystals have also been successfully prepared by the microfluidic impinging jet technology [106]. The size of drug nanoparticles prepared by the microfluidic impinging jet technology was smaller than those prepared by the conventional batch method.…”
Section: Drug Nanosuspensionsmentioning
confidence: 99%
“…In the case of crystallization, it was expected that a smaller size of crystals could be obtained by this method compared with the usual mixing operation with a normal stirrer. After preparing a fine crystal suspension of phenytoin as a model of a poorly water-soluble drug and polyvinyl alcohol (PVA) as a dispersion stabilizer, the crystal form, solubility, absorbability after oral administration, etc., of the crystals were evaluated (Tahara et al, 2016). In the case of high-pressure crystallization, the particle size was about half of that in the case of normal crystallization.…”
Section: Micronizing Drug Crystals and Dosage Form Designmentioning
confidence: 99%
“…The bottom-up method can produce nano-sized particles by crystallization from a solution or coacervation with a sharp size distribution. We have previously prepared nanocrystal suspensions of poorly water-soluble drugs using a continuous crystallizer (PureNano TM ) [14]. In the PureNano TM system, crystallization is immediately performed by a high shearing force, which is generated after the rapid feeding of Pharmaceutics 2022, 14, 394 2 of 14 aqueous and organic solutions to the collision jet field.…”
Section: Introductionmentioning
confidence: 99%