In vitro and in vivo evaluation of the pH-neutral bioactive glass as high performance bone grafts

Zhao, Huiyu; Liang, Guojun; Liang, Wenquan; Li, Qingchu; Huang, Bin; Li, Ailing; Qiu, Dong; Jin, Dadi

doi:10.1016/j.msec.2020.111249

Cited by 16 publications

(20 citation statements)

References 39 publications

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“… 25 Furthermore, PSC could better promote the proliferation, migration and mineralization as well as the osteogenic and angiogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) than 45S5 bioglass and beta-tricalcium phosphate (β-TCP). 26 The aim of this study was to prepare a root canal sealer with good performance utilizing the favorable mineralization property and biocompatibility of PSC. The addition of small amounts of organic polymers, such as sodium alginate, could significantly improve the cohesiveness, anti-washout property and injectability of BG and did not affect the property of mineralization.…”

Section: Discussionmentioning

confidence: 99%

“… 23 , 24 Studies indicated that PSC could promote the rapid formation of HA in vitro and encourage bone and dental–pulp complex-like tissue regeneration in vivo for its high bioactive potential. 23 , 25 , 26 PSC thus seems to be a satisfying material for the root canal sealer in these regards. Therefore, this study aimed to prepare a novel bioactive root canal sealer based on PSC and evaluate their physicochemical properties, sealing ability, biocompatibility in order to explore the feasibility of application in the endodontic treatment.…”

Section: Introductionmentioning

confidence: 94%

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A novel bioactive glass-based root canal sealer in endodontics

Huang

Liu

et al. 2022

Journal of Dental Sciences

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Background/purpose Bioactive glass (BG), one type of bioceramics, shows similar or better characteristics to calcium silicate which has been regarded as a promising root filling material in endodontics. This study aimed to develop a novel BG-based root canal sealer for endodontics. Materials and methods The novel BG-based root canal sealer was composed of phytic acid derived bioactive calcium phosphosilicate glass named PSC mixed with zirconium oxide (ZrO 2 ) as powder, and phosphate solution (PS) dissolved with sodium alginate (SA) named PS-SA as liquid. Moreover, the physicochemical properties, mineralization, sealing ability and biocompatibility of the novel BG-based root canal sealer were evaluated. Results This study developed a novel BG-based sealer named BGS-SA-Zr which contained the powder of PSC and ZrO 2 and the liquid of PS-SA. Results indicated that the flow, film thickness and radiopacity of BGS-SA-Zr conformed to ISO 6876:2012. The setting time and solubility of BGS-SA-Zr were 53.7 ± 1.5 min and 21.46 ± 0.54%, respectively. The pH value of the simulated body fluid (SBF) immersed with BGS-SA-Zr raised slightly up to 7.70. The CCK-8 assay indicated that BGS-SA-Zr had no cytotoxic effects on MG-63 cells. After immersion in SBF for 4 weeks, dense hydroxyapatite crystals were observed on the surface of BGS-SA-Zr. Furthermore, there was no difference in the sealing ability between BGS-SA-Zr and the bioceramic sealer iRoot SP whether setting at 1 day or immersed in SBF for 4 weeks ( P > 0.05). Conclusion Our results suggest that the novel BG-based sealer may be a promising sealer for endodontic treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

A novel bioactive glass-based root canal sealer in endodontics

Huang

Liu

et al. 2022

Journal of Dental Sciences

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“…Moreover, PSC induced angiogenic and osteogenic differentiation of BMSCs via the PI3K/Akt/HIF-1α route. This synergistic influence of the PI3K/Akt/HIF-1α route on angiogenic and osteogenic differentiation of BMSCs offered that biomedical materials may enhance the novel bone fabrication by multiple signal routes, therefore shedding light on the addition advancement of materials with higher function [8]. In addition, BAG exhibited osteoinductive properties, like 45S5 BG which promotes osteoblastic activity due to the release of its ions and apatite crystallization at its surface.…”

Section: Bone Graftingmentioning

confidence: 97%

“…Their reactive surfaces lead to biological activity induction and strong bond formation with living tissue like bone [2]. They are employed in other areas such as engineering of soft tissue [3][4][5][6][7][8], antibacterial factors [9][10][11][12][13][14], coatings of the dental implant [15][16][17][18][19][20][21][22], drug delivery [18-20, 23, 24], regeneration of bone [14,25], and grafting of bone [6,8,26,27].…”

Section: P R E -P R O O F 1 Introductionmentioning

confidence: 99%

A comprehensive review of bioactive glass: synthesis, ion substitution, application, challenges, and future perspectives

Sidhu

Borges²,

Yusuf

et al. 2021

jcc

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Bioactive glass (BG) and glass-ceramics (GC) have been employed for bone treatment tissue engineering applications. Bioactive glasses/bioglasses can be considered promising materials for bone-regenerative scaffolds fabrication, owing to the adaptable properties that make them appropriately be designed regarding their composition. The essential properties of bioactive glasses, enabling them to be applied in the engineering of bone tissue, can be explained as their potential to augment differentiation osteoprogenitor and cells of mesenchymal stem cells, enzyme activity, osteoblast adhesion, and revascularization. Much research is conducted for the development of phosphate glasses, borate/borosilicate BGs, and silicate. Accordingly, some metal-based glasses have also been surveyed for tissue engineering uses, technologically and biomedically. Many rare elements can also be incorporated in the network of the glass to achieve promising properties, possessing a positive influence on the associated angiogenesis and/or remodeling of bone. This review motivates for providing an overview toward bioactive glasses' general requirements, composition, production, and impact of ion substitution on bioactive glass. Attention has also been given to developments of bioactive glass applications in bone grafting, bone regeneration, drug delivery, dental implant coatings, antibacterial agents, and soft tissue engineering as well as challenges and future perspectives.

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“…Bone defects are caused by surgery, fractures, tumors, or trauma and can affect people of all ages [1]. Typical healing of a fracture is characterized by four chronological phases: anabolic phase, inflammatory stage, endochondral stage, and remodeling phase of callus into bone [2].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Calcium Sulfate Dihydrate into a Mesoporous Calcium Silicate/Poly-ε-Caprolactone Scaffold to Regulate the Release of Bone Morphogenetic Protein-2 and Accelerate Bone Regeneration

et al. 2021

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Tissue engineering and scaffolds play an important role in tissue regeneration by supporting cell adhesion, proliferation, and differentiation. The design of a scaffold is critical in determining its feasibility, and it is critical to note that each tissue is unique in terms of its morphology and composition. However, calcium-silicate-based scaffolds are undegradable, which severely limits their application in bone regeneration. In this study, we developed a biodegradable mesoporous calcium silicate (MS)/calcium sulfate (CS)/poly-ε-caprolactone (PCL) composite and fabricated a composite scaffold with 3D printing technologies. In addition, we were able to load bone morphogenetic protein-2 (BMP-2) into MS powder via a one-step immersion procedure. The results demonstrated that the MS/CS scaffold gradually degraded within 3 months. More importantly, the scaffold exhibited a gradual release of BMP-2 throughout the test period. The adhesion and proliferation of human dental pulp stem cells on the MS/CS/BMP-2 (MS/CS/B) scaffold were significantly greater than that on the MS/CS scaffold. It was also found that cells cultured on the MS/CS/B scaffold had significantly higher levels of alkaline phosphatase activity and angiogenic-related protein expression. The MS/CS/B scaffold promoted the growth of new blood vessels and bone regeneration within 4 weeks of implantation in rabbits with induced critical-sized femoral defects. Therefore, it is hypothesized that the 3D-printed MS/CS/B scaffold can act both as a conventional BMP-2 delivery system and as an ideal osteoinductive biomaterial for bone regeneration.

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In vitro and in vivo evaluation of the pH-neutral bioactive glass as high performance bone grafts

Cited by 16 publications

References 39 publications

A novel bioactive glass-based root canal sealer in endodontics

A novel bioactive glass-based root canal sealer in endodontics

A comprehensive review of bioactive glass: synthesis, ion substitution, application, challenges, and future perspectives

Incorporation of Calcium Sulfate Dihydrate into a Mesoporous Calcium Silicate/Poly-ε-Caprolactone Scaffold to Regulate the Release of Bone Morphogenetic Protein-2 and Accelerate Bone Regeneration

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