In vitro and in vivo studies on pure Mg, Mg–1Ca and Mg–2Sr alloys processed by equal channel angular pressing

Li, Wenting; Shen, Yating; Shen, Jie; Shen, Danni; Liu, Xiao; Zheng, Yufeng; Yeung, K.W.K.; Guan, Shaokang; Kulyasova, Olya B.; Valiev, Ruslan Z.

doi:10.1016/j.nanoms.2020.03.004

Cited by 31 publications

(33 citation statements)

References 61 publications

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“…The composition of the environment plays an important role in corrosion rate evolution, the more the environment is similar to living organisms, the lower the corrosion rate will be. Thus, the hypothesis of in vivo corrosion rate being lower than in vitro is raised [ 8 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for Orthopedic Applications

et al. 2020

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Use of magnesium implants is a new trend in orthopedic research because it has several important properties that recommend it as an excellent resorbable biomaterial for implants. In this study, the corrosion rate and behavior of magnesium alloys during the biodegradation process were determined by in vitro assays, evolution of hydrogen release, and weight loss, and further by in vivo assays (implantation in rabbits’ bone and muscle tissue). In these tests, we also used imaging assessments and histological examination of different tissue types near explants. In our study, we analyzed the Mg-1Ca alloy and all the hypotheses regarding the toxic effects found in in vitro studies from the literature and those from this in vitro study were rejected by the data obtained by the in vivo study. Thus, the Mg-1Ca alloy represents a promising solution for orthopedic surgery at the present time, being able to find applicability in the small bones: hand or foot.

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Section: Discussionmentioning

confidence: 99%

Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for Orthopedic Applications

et al. 2020

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“…Figure 9A–D shows the quantification and images obtained by Live/Dead assay on day 7. All groups were considered non‐cytotoxic based on the ISO standard 10,993–5 (cell viability >70%) 15,40 . The Mg‐Sc‐Sr/HT300 and Mg‐Sc‐Sr/HT400 discs showed the highest viability with values of 90.8% ± 1.1% and 90.9% ± 0.7%, respectively.…”

Section: Resultsmentioning

confidence: 99%

An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications

Aboutalebianaraki

Zeblisky

Sarker

et al. 2022

J Biomedical Materials Res

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The aim of this study was to develop a novel biodegradable magnesium (Mg) alloy for bone implant applications. We used scandium (Sc; 2 wt %) and strontium (Sr; 2 wt %) as alloying elements due to their high biocompatibility, antibacterial efficacy, osteogenesis, and protective effects against corrosion. In the present work, we also examined the effect of a heat treatment process on the properties of the Mg‐Sc‐Sr alloy. Alloys were manufactured using a metal casting process followed by heat treatment. The microstructure, corrosion, mechanical properties, antibacterial activity, and osteogenic activity of the alloy were assessed in vitro. The results showed that the incorporation of Sc and Sr elements controlled the corrosion, reduced the hydrogen generation, and enhanced mechanical properties. Furthermore, alloying with Sc and Sr demonstrated a significantly enhanced antibacterial activity and decreased biofilm formation compared to control Mg. Also, culturing Mg‐Sc‐Sr alloy with human bone marrow‐derived mesenchymal stromal cells showed a high degree of biocompatibility (>90% live cells) and a significant increase in osteoblastic differentiation in vitro shown by Alizarin red staining and alkaline phosphatase activity. Based on these results, the Mg‐Sc‐Sr alloy heat‐treated at 400°C displayed optimal mechanical properties, corrosion rate, antibacterial efficacy, and osteoinductivity. These characteristics make the Mg‐Sc‐Sr alloy a promising candidate for biodegradable orthopedic implants in the fixation of bone fractures such as bone plate‐screws or intramedullary nails.

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“…In this case, the accumulation of crystal lattice defects with a density sufficient for the formation of an ultrafine-grained (UFG) structure is hindered by the processes of recovery and recrystallization. Therefore, it is advisable to carry out ECAP with a stepwise decrease in the processing temperature for microstructure refinement [26][27][28][29] that would allow accumulation of sufficiently high dislocation density. In this work, the effect of ECAP on the structure, texture, mechanical properties, and corrosion behavior of magnesium-based alloys Mg-6.0%Ag and Mg-10.0%Gd was studied.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Equal-Channel Angular Pressing on Microstructure, Mechanical Properties, and Biodegradation Behavior of Magnesium Alloyed with Silver and Gadolinium

et al. 2020

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The effect of equal channel angular pressing (ECAP) on the microstructure, texture, mechanical properties, and corrosion resistance of the alloys Mg-6.0%Ag and Mg-10.0%Gd was studied. It was shown that ECAP leads to grain refinement of the alloys down to the average grain size of 2–3 μm and 1–2 μm, respectively. In addition, in both alloys the precipitation of fine particles of phases Mg54Ag17 and Mg5Gd with sizes of ~500–600 and ~400–500 nm and a volume fraction of ~9% and ~8.6%, respectively, was observed. In the case of the alloy Mg-6.0%Ag, despite a significant grain refinement, a drop in the strength characteristics and a nearly twofold increase in ductility (up to ~30%) was found. This behavior is associated with the formation of a sharp inclined basal texture. For alloy Mg-10.0%Gd, both ductility and strength were enhanced, which can be associated with the combined effect of significant grain refinement and an increased probability of prismatic and basal glide. ECAP was also shown to cause a substantial rise of the biodegradation rate of both alloys and an increase in pitting corrosion. The latter effect is attributed to an increase in the dislocation density induced by ECAP and the occurrence of micro-galvanic corrosion at the matrix/particle interfaces.

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In vitro and in vivo studies on pure Mg, Mg–1Ca and Mg–2Sr alloys processed by equal channel angular pressing

Cited by 31 publications

References 61 publications

Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for Orthopedic Applications

Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for Orthopedic Applications

An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications

The Effect of Equal-Channel Angular Pressing on Microstructure, Mechanical Properties, and Biodegradation Behavior of Magnesium Alloyed with Silver and Gadolinium

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