In vitro and in vivo testing of the antiviral effect of favipiravir (T705) against the neurotropic Chandipura virus

Cain, Michaela; Ly, Hinh

doi:10.1002/jmv.28960

Journal of Medical Virology

2023

DOI: 10.1002/jmv.28960

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In vitro and in vivo testing of the antiviral effect of favipiravir (T705) against the neurotropic Chandipura virus

Michaela Cain

Hinh Ly

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2024

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Cited by 2 publications

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Re-emerging Chandipura vesiculovirus: A cause of concern for global health

Padhi,

Agarwal,

Mishra

et al. 2024

VirusDis.

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Re-emerging Chandipura vesiculovirus: A cause of concern for global health

Padhi,

Agarwal,

Mishra

et al. 2024

VirusDis.

View full text Add to dashboard Cite

Covalent Organic Framework-Based Theranostic Platforms for Restricting H1N1 Influenza Virus Infection

Ding,

Ji,

Liu

et al. 2024

IJN

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Background: Influenza A (H1N1) virus is a highly contagious respiratory disease that causes severe illness and death. Vaccines and antiviral drugs are limited by viral variation and drug resistance, so developing efficient integrated theranostic options appears significant in anti-influenza virus infection. Methods: In this study, we designed and fabricated covalent organic framework (COF) based theranostic platforms (T705@DATA-COF-Pro), which was composed of an RNA polymerase inhibitor (favipiravir, T705), the carboxyl-enriched COF (DATA-COF) nanocarrier and Cy3-labeled single DNA (ssDNA) probe. Results:The multi-porosity COF core provided an excellent micro-environment and smooth delivery for T705. The ssDNA probe coating bound to the nucleic acids of H1N1 selectively, thus controlling drug release and allowing fluorescence imaging. The combination of COF and probe triggered the synergism, promoting drug further therapeutic outcomes. With the aid of T705@DATA-COF-Pro platforms, the H1N1-infected mouse models lightly achieved diagnosis and significantly prolonged survival. Conclusion:This research underscores the distinctive benefits and immense potential of COF materials in nano-preparations for virus infection, offering novel avenues for the detection and treatment of H1N1 virus infection.

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In vitro and in vivo testing of the antiviral effect of favipiravir (T705) against the neurotropic Chandipura virus

Cited by 2 publications

References 13 publications

Re-emerging Chandipura vesiculovirus: A cause of concern for global health

Re-emerging Chandipura vesiculovirus: A cause of concern for global health

Covalent Organic Framework-Based Theranostic Platforms for Restricting H1N1 Influenza Virus Infection

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