In vitro and in vivo studies to evaluate the feasibility of Zn-0.1Li and Zn-0.8Mg application in the uterine cavity microenvironment compared to pure zinc

Guo, Bao; Fan, Qianqian; Ge, Dongfeng; Wang, Kun; Sun, Min; Zhang, Zechuan; Guo, Hui; Yang, Hongtao; He, Bin; Zheng, Yufeng

doi:10.1016/j.actbio.2020.12.048

Cited by 25 publications

(8 citation statements)

References 42 publications

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“…4d), the corrosion products mainly comprised the elements Zn, P, and O, which may be attributed to the formation of Zn 3 (PO 4 ) 2 . 10 On the coating surface of the CP/TA-coated Zn substrate, a few cracks and spalling pits were present, and a small amount of corrosion products observed by EDS indicated an inadequate long-term corrosion resistance of the CP/TA coating. By contrast, the three hybrid CP/TA@Cu coatings showed homogeneous and smooth surfaces without any signs of corrosion, which can probably be attributed to the crosslinking enhancement by the addition of Cu 2+ .…”

Section: Resultsmentioning

confidence: 94%

“…The bare Zn substrate showed a rapid increase in pH value in the first 6 days, which then decreased until day 25, basically consistent with previous reports (eqn (S1)–(S7), see ESI†). 10,47 While the pH of the coated Zn samples presented a slightly increasing trend in the initial stage, their increase rate and highest pH values were lower than those of the bare Zn substrate. In addition, the Zn 2+ release rate of coated Zn alloys was much lower than that of bare Zn alloys, especially in the initial stage of the test (inset: a partial, enlarged view of Fig.…”

Section: Resultsmentioning

confidence: 97%

“…7,8 As an essential trace element for the human body, Zn plays an important and irreplaceable role in the human immune system, reproductive system, and children's growth and development, and a daily intake of 8-18 mg Zn is recommended. 9,10 As a further advantage of Zn-alloy implants, the released Zn ions (Zn 2+ ) possess natural antibacterial properties, through which complications caused by implant infections can be avoided. Therefore, Zn alloys with appropriate degradation rates and good biological effects have quickly emerged as the preferred material for the manufacture of AMS.…”

Section: Introductionmentioning

confidence: 99%

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Facile fabrication of biodegradable endothelium-mimicking coatings on bioabsorbable zinc-alloy stents by one-step electrophoretic deposition

et al. 2022

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Facile fabrication of biodegradable endothelium-mimicking coatings on bioabsorbable zinc-alloy stents by one-step electrophoretic deposition

et al. 2022

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“…Variations in ionic concentrations and pH values of the MEM solution after contact with the various Mg samples provided additional information regarding the in vitro degradation behavior. 29,41,48,49 Traces of all the elements of interest in GaSrPO 4 @Mg, that is, Mg, Sr, and Ga, were monitored in MEM as a function of immersion time, indicating the continuing but controlled degradation kinetics of the GaSrPO 4 coating when in contact with MEM (Figure 4a−c). At any time point, it was evident that the bare Mg generated the highest ionic concentrations of Mg and OH − (alkaline pH, Figure 4d), indicating degradation of metallic Mg without a protective coating.…”

Section: 2mentioning

confidence: 99%

Gallium–Strontium Phosphate Conversion Coatings for Promoting Infection Prevention and Biocompatibility of Magnesium for Orthopedic Applications

Song

Qiu

et al. 2022

ACS Biomater. Sci. Eng.

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Device-associated infections remain a clinical challenge. The common strategies to prevent bacterial infection are either toxic to healthy mammalian cells and tissue or involve high doses of antibiotics that can prompt long-term negative consequences. An antibiotic-free coating strategy to suppress bacterial growth is presented herein, which concurrently promotes bone cell growth and moderates the dissolution kinetics of resorbable magnesium (Mg) biomaterials. Pure Mg as a model biodegradable material was coated with gallium-doped strontium-phosphate through a chemical conversion process. Gallium was distributed in a gradual manner throughout the strontium-phosphate coating, with a compact structure and a gallium-rich surface. It was demonstrated that the coating protected the underlying Mg parts from significant degradation in minimal essential media at physiological conditions over 9 days. In terms of bacteria culture, the liberated gallium ions from the coatings upon Mg specimens, even though in minute quantities, inhibited the growth of Gram-positiveStaphylococcus aureus, Gram-negative Escherichia coli, andPseudomonas aeruginosa  key pathogens causing infection and early failure of the surgical implantations in orthopedics and trauma. More importantly, the gallium dopants displayed minimal interferences with the strontium-phosphate-based coating which boosted osteoblasts and undermined osteoclasts in in vitro co-cultures. This work provides a new strategy to prevent bacterial infection and control the degradation behavior of Mg-based orthopedic implants, while preserving osteogenic features of the devices.

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“…When the zinc and its alloys are exposed to the electrolyte, the following electrochemical reactions would occur [28]:…”

Section: Degradation Behaviormentioning

confidence: 99%

Preliminary Investigation on Degradation Behavior and Cytocompatibility of Ca-P-Sr Coated Pure Zinc

Xie

Tang

et al. 2021

Coatings

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Zinc and its alloys show a good application prospect as a new biodegradable material. However, one of the drawbacks is that Zn and its alloys would induce the release of more Zn ions, which are reported to be cytotoxic to cells. In this study, a Ca-P-Sr bioactive coating was prepared on the surface of pure zinc by the hydrothermal method to address this issue. The morphology, thickness, and composition were characterized, and the effects of the coating on the degradation, cell viability, and ALP staining were investigated. The results demonstrated that the degradation rate of pure zinc was reduced, while the cytocompatibility was significantly improved after pure zinc was treated with Ca-P-Sr coating. It is considered that the Ca-P-Sr bioactive coating prepared by the hydrothermal method has promising application in the clinic.

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In vitro and in vivo studies to evaluate the feasibility of Zn-0.1Li and Zn-0.8Mg application in the uterine cavity microenvironment compared to pure zinc

Cited by 25 publications

References 42 publications

Facile fabrication of biodegradable endothelium-mimicking coatings on bioabsorbable zinc-alloy stents by one-step electrophoretic deposition

Facile fabrication of biodegradable endothelium-mimicking coatings on bioabsorbable zinc-alloy stents by one-step electrophoretic deposition

Gallium–Strontium Phosphate Conversion Coatings for Promoting Infection Prevention and Biocompatibility of Magnesium for Orthopedic Applications

Preliminary Investigation on Degradation Behavior and Cytocompatibility of Ca-P-Sr Coated Pure Zinc

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