In vitro andin vivo antineoplastic effects of ortrovanadate

Effects of tyrosine kinase and phosphatase inhibitors on mitosis progression in synchronized tobacco BY-2 cells

“…Though, in cells incubated with sodium orthovanadate the mitotic index was reduced, which is in accordance with results obtained for animal cells [36]. It was shown for different animal cells that sodium orthovanatade protects cells from apoptosis but that in certain situations it can indeed induce growth inhibition and apoptosis [37,38]. Downregulation of several tyrosine phosphatases resulted in a significantly reduced mitotic index [39].…”

Vanadium compounds in medicine

“…Tumor cells derived from human placenta HTB-14, the murine tumor cell line MDAY-D2 and endothelium murine cells EDMA were inhibited by 5-50 M sodium vanadate; the cells in active proliferation were more sensible to the inhibitory action of the V V -derivatives [226].…”

Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review

“…However, vanadium therapy fails in other metabolic complications of STZ-rats that are corrected by the action of insulin, as the daily weight-gain, that can be only partially corrected by therapy with this trace mineral [76], and the increased rate in muscle protein degradation, where vanadium is ineffective [77]. In addition, it is implicated in the inhibition of protein synthesis, amino acid uptake and mitogenesis, but these effects do not necessarily represent a risk, since the inhibition of growth effects of insulin could alleviate macrovascular disease [78], besides, it has been shown to have anti-tumor properties and is being studied as a potential therapeutic agent in this regard [79][80][81][82][83].…”