In vitro Anti-Alzheimer and Anti Oxidant activity of the Peels of<i>Citrus maxima</i>fruits

Vijayalakshmi, P.; Radha, R

doi:10.5958/2321-5836.2016.00005.7

Cited by 11 publications

(3 citation statements)

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“…are extracted using solvents like ethanol (4). Ethanolic peel extract in the present study reveals significantly higher scavenging potential which has been previously reported (17). Phytoconstituents in the extract can evidently be the reason for scavenging over damage caused by free radicals, phytoconstituents execute via donating a hydrogen atom.…”

Section: Gc-ms Profiling Of Ethanolic Fraction Of Cmaxima Peelsupporting

confidence: 56%

Phytochemical profiling, total flavonoid, total phenolic content and in-vitro antioxidant evaluation of Citrus maxima extract

Monteiro¹,

Shetty²,

Ranjitha³

et al. 2022

Biomedicine

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Introduction and Aim: Citrus fruits are rich in polyphenolic compounds. The conventional medical system has utilized the fruit’s entire composition including the peel for its diverse biological functions. With this, the study aimed to assess and compare the phytochemical, in-vitro antioxidant analysis as well as polyphenol and flavonoid content of Citrus maxima juice, aqueous and ethanolic extracts of its pulp and peel. Materials and Methods: Qualitative phytochemical screening, total phenolic content and total flavonoid content and different in-vitro antioxidant assays like total antioxidant capacity (TAC), Ferric reducing antioxidant power assay (FRAP), 2,2-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay were carried out to evaluate the in-vitro antioxidant potential in the juice, aqueous and ethanolic extract of pulp and peel of C. maxima. Gas chromatography–Mass spectrometry (GC–MS) analysis was performed in the peel ethanolic extract to identify the compounds present. Results: Preliminary phytochemical analysis revealed the presence of triterpenoids and steroids, glycosides, alkaloids, flavonoids, carbohydrates and vitamin C in all the C. maxima crude extracts. Tannins were present only in pulp of ethanol extract and in both aqueous and ethanol extracts of peel. Resins were present in the juice and ethanol extract of pulp and peel. The total phenol and total flavonoid content was comparatively higher in ethanolic extracts of peel. All the extracts showed dose-dependent free radical scavenging activity. The reducing potential of the C.maxima extractives increased with the increase in its concentration. GC-MS analysis of ethanolic peel extract identified key constituents with pharmacological effects. The ethanolic peel extract showed good antioxidant activity and free radical scavenging activity when compared to other extracts. Conclusion: The results indicated that ethanolic peel extract of Citrus maxima revealed the highest presence of polyphenolic compounds, which are secondary plant metabolites with potential antioxidant activity.

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Section: Gc-ms Profiling Of Ethanolic Fraction Of Cmaxima Peelsupporting

confidence: 56%

Phytochemical profiling, total flavonoid, total phenolic content and in-vitro antioxidant evaluation of Citrus maxima extract

Monteiro¹,

Shetty²,

Ranjitha³

et al. 2022

Biomedicine

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“…The freeze-dried fruit extract of C. maxima exhibited 6609 μ ·mol Fe 2+ /L antioxidant power through the ferric-reducing antioxidant powder (FRAP) assay which is very similar to the standard drug ascorbic acid [ 83 ]. The presence of major phytochemicals might be the reason for showing significant antioxidant activity by C. maxima extracts [ 14 , 84 , 85 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…During the experiments performed using Ellman's colorimetric and scopolamine-induced Alzheimer's methods, ethanolic, hexane, ethyl acetate, and aqueous extracts of C. maxima fruit peel exhibited potent anti-Alzheimer's activity. Similarly, it was found that the brain acetylcholinesterase level was decreased by leaf extract and showed anti-Alzheimer's activity [ 14 , 90 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Citrus maxima (Brum.) Merr. (Rutaceae): Bioactive Chemical Constituents and Pharmacological Activities

Sapkota¹,

Devkota

Poudel

2022

Evidence-Based Complementary and Alternative Medicine

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Citrus maxima (Burm). Merr. (family Rutaceae), commonly known as Pomelo, is an ethnomedicinally, pharmacologically, and phytochemically valued species. Various ethnomedicinal reports have revealed the use of C. maxima for cough, fever, asthma, diarrhea, ulcer, and diabetes and as a sedative. Numerous phytochemicals have been reported from C. maxima such as polyphenols, terpenoids, sterols, carotenoids, vitamins, and amino acids. The plant possesses significant bioactivities like antioxidant, antimicrobial, anti-inflammatory, analgesic, anticancer, antidiabetic, anti-Alzheimer’s disease, insecticidal, anxiolytic, hepatoprotective, antimalarial, and antiobesity. Extensive research is necessary to explore the detailed mechanism of action of extracts and compounds to design effective medicines, herbal products, and functional foods.

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Pomelo

Kushwaha,

Singh,

Kushwaha

et al. 2023

Recent Advances in Citrus Fruits

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In vitro Anti-Alzheimer and Anti Oxidant activity of the Peels ofCitrus maximafruits

Cited by 11 publications

References 0 publications

Phytochemical profiling, total flavonoid, total phenolic content and in-vitro antioxidant evaluation of Citrus maxima extract

Phytochemical profiling, total flavonoid, total phenolic content and in-vitro antioxidant evaluation of Citrus maxima extract

Citrus maxima (Brum.) Merr. (Rutaceae): Bioactive Chemical Constituents and Pharmacological Activities

Pomelo

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