In-vitro Anti-Bacterial Activity of Extracts of Euphorbia abyssinica (Desert Candle) Stem-Bark and Latex

Tarh, Jacqueline Ebob; Iroegbu, Christian Ukwuoma

doi:10.9734/jamb/2017/32277

Cited by 8 publications

(14 citation statements)

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“…FIC index was also calculated using the formula, FIC index = ΣFIC Euphorbia + FIC Coleus. FIC index value of 1 indicates additive interaction, < 1, synergy, >1< 2, Indifference and >2, antagonism [20].…”

Section: The Checkerboard Assay Methods Of Evaluating the Antifungal Ementioning

confidence: 99%

“…The 50% methanol extracts were further evaluated in combination using the CheckerBoard assay method described by Tarh and Iroegbu [20]. Solutions of the plant extracts were prepared, each in Sabouraud broth, and diluted using the continuous variation model, that was, by serially reducing the concentration by 10% with broth down to concentrations below the MIC.…”

Section: Checker Board Assaymentioning

confidence: 99%

“…The effects of 50% methanol extracts of Euphorbia abyssinica and Coleus sp. were evaluated by a kinetic time kill assay using the macro broth dilution technique as described by Tarh and Iroegbu, [20]. The extracts were reconstituted in 20% Dimethyl Sulfoxide (DMSO) and appropriately diluted to the required concentrations.…”

Section: Time Kill Assaymentioning

confidence: 99%

“…To add to the problem of resistance, treatment failure, and toxicity [9], most synthetic drugs are unaffordable to most people in rural and less developed areas of the world [18]. For the latter, their existence and survival history would be incomplete without a mention of the role of plants as sources of food and/or medicines [18,19,20]. Plants are naturally endowed with primary and secondary metabolites that are incidentally very important nutrients or medicines to man and livestock [19,21,22].…”

Section: Introductionmentioning

confidence: 99%

“…are two medicinal plants, with a broad spectrum of activity against pathogenic microorganisms. The native population of Kendem in Cameroon, often use these two plants to prevent excessive loss of blood after childbirth, treat cuts, pruritus, superficial infections of the body, and diseases of the airways [20]; also as antispasmodic, and antihistamine, as well as constricting and releasing tension from smooth muscles [26,20]. E. abyssinica is an evergreen, cactus-like plant that has been classified in the family Euphorbiaceae [20].…”

Section: Introductionmentioning

confidence: 99%

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Antifungal Effects of Combined Extracts of Euphorbia abyssinica and Coleus Species

Tarh

Ekong

Iroegbu

2019

IJPR

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Although, different plant extracts have frequently been used singly and in combinations in folklore treatment of different ailments, the hidden truth behind their activity and efficacy is still to be fully scientifically established. Aim: To evaluate the effects of combined 50% methanol extracts of Euphorbia abyssinica (Desert Candle), and Coleus sp. on Candida albicans, Trichophyton mentagrophytes, Microsporum gypseum and Epidermophyton floccossum. Study Design: The completely randomised block design, two-way analysis of variance was used to analyse the data and Duncan’s New Multiple Range Test, for mean separation. Place and Duration of Study: The research was carried out in the Department of Microbiology, University of Nigeria Nsukka, Enugu State, Nigeria, between April 2011 and August 2012. Methodology: All the fungal strains used in the research were collected from the University of Nigeria Teaching Hospital Enugu, Nigeria. Susceptibility testing was done using a pour-plate method, while the checkerboard and Time-kill assays were employed to evaluate the efficacy of the different combinations of the two plant extracts. Results: The individual plant extracts inhibited all the fungal strains tested at different concentrations; but Coleus sp. extracts were observed to be more active than Euphorbia abyssinica extracts. The extract combinations inhibited the test fungi for more than two weeks. In the Time Kill assay, the combinations showed synergy on E. Floccossum only. It showed additive or antagonistic activity on the rest of the fungi tested. The Checkerboard combinations showed synergy on T. mentagrophytes, M. gypseum, and E. foccossum. Epidermophyton foccosum was the most susceptible among the fungi tested while C. albicans was the least susceptible. The control drug voriconazole also inhibited all the fungi tested. Significant antifungal activity (P=0.05) was observed in the checkerboard assay more than in the Time Kill assay. Conclusion: These findings simply authenticate some of the folklore claims that these plants have a wide range of curative uses, suggesting that they can be used as alternative sources of agents for the treatment of resistant fungal infections.

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Section: The Checkerboard Assay Methods Of Evaluating the Antifungal Ementioning

confidence: 99%

Section: Checker Board Assaymentioning

confidence: 99%

Section: Time Kill Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antifungal Effects of Combined Extracts of Euphorbia abyssinica and Coleus Species

Tarh

Ekong

Iroegbu

2019

IJPR

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Multifarious global flora fabricated phytosynthesis of silver nanoparticles: a green nanoweapon for antiviral approach including SARS-CoV-2

Chinnappa

Punnaivalavan

Prabha³

et al. 2022

Int Nano Lett

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The progressive research into the nanoscale level upgrades the higher end modernized evolution with every field of science, engineering, and technology. Silver nanoparticles and their broader range of application from nanoelectronics to nano-drug delivery systems drive the futuristic direction of nanoengineering and technology in contemporary days. In this review, the green synthesis of silver nanoparticles is the cornerstone of interest over physical and chemical methods owing to its remarkable biocompatibility and idiosyncratic property engineering. The abundant primary and secondary plant metabolites collectively as multifarious phytochemicals which are more peculiar in the composition from root hair to aerial apex through various interspecies and intraspecies, capable of reduction, and capping with the synthesis of silver nanoparticles. Furthermore, the process by which intracellular, extracellular biological macromolecules of the microbiota reduce with the synthesis of silver nanoparticles from the precursor molecule is also discussed. Viruses are one of the predominant infectious agents that gets faster resistance to the antiviral therapies of traditional generations of medicine. We discuss the various stages of virus targeting of cells and viral target through drugs. Antiviral potential of silver nanoparticles against different classes and families of the past and their considerable candidate for up-to-the-minute need of complete addressing of the fulminant and opportunistic global pandemic of this millennium SARS-CoV2, illustrated through recent silver-based formulations under development and approval for countering the pandemic situation.

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Biogenic synthesis of copper oxide nanoparticles using Clausena anisata leaf and Euphorbia abyssinica bark extracts and its comparative study of antibacterial activities

Dejene,

Feyisa Bogale,

Yadeta

et al. 2024

Results in Chemistry

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In-vitro Anti-Bacterial Activity of Extracts of Euphorbia abyssinica (Desert Candle) Stem-Bark and Latex

Cited by 8 publications

References 0 publications

Antifungal Effects of Combined Extracts of Euphorbia abyssinica and Coleus Species

Antifungal Effects of Combined Extracts of Euphorbia abyssinica and Coleus Species

Multifarious global flora fabricated phytosynthesis of silver nanoparticles: a green nanoweapon for antiviral approach including SARS-CoV-2

Biogenic synthesis of copper oxide nanoparticles using Clausena anisata leaf and Euphorbia abyssinica bark extracts and its comparative study of antibacterial activities

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