In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating

Chen, W.; Liu, Y.; Courtney, Harry S.; Bettenga, M.; Agrawal, C. Mauli; Bumgardner, Joel D.; Ong, Joo L.

doi:10.1016/j.biomaterials.2006.07.003

Cited by 551 publications

(361 citation statements)

References 65 publications

Supporting

Mentioning

316

Contrasting

Unclassified

Order By: Relevance

“…It was observed that 3 % Ag-HAp exhibited maximum activity as compared to 1 and 5 % Ag-HAp for both the test organisms. Antimicrobial activity of Ag-HAp based compounds such as plasma sprayed silver containing HAp coatings on Ti plates (Chen et al 2008), magnetron co-sputtered silver containing HAp coatings (Chen et al 2006), Ag-nHAp/TiO 2 /PA66 scaffolds (Xia et al 2010), silver-hydroxyapatite/titania film on titanium plates (Mo et al 2008) and HAp self assembled calcium phosphate glasses (Simon et al 2008) has been attributed to the Ag ions released into the medium. It is well known that silver ions and silver based compounds can destroy cell membranes and cell walls of bacteria and affect their growth (Woo et al 2008;Furr et al 1994).…”

Section: Resultsmentioning

confidence: 99%

“…According to ASTM F 756-00, samples with hemolysis rate less than 2 % can be considered nonhemolytic thus 1 and 3 % Ag-HAp are suitable for biomedical applications. It has been shown that the hemolysis rate is influenced by the silver concentration and the degree of crystallinity, with the latter having a more dominating influence on hemolysis (Chen et al 2006;Stanic et al 2011;Wiessner et al 1988). …”

Section: Resultsmentioning

confidence: 99%

“…Its high biocompatibility, allows tissue to infiltrate and chemically bond with it. The success of these orthopedic and dental implants is dependent on implant osteointegration, but the long term survival is dependent on its resistance to bacterial infections (Chen et al 2006). A disadvantage of HAp is that, proteins, amino acids, and other organic substances are easily adsorbed, which could create an environment conducive for the growth of bacteria on its surface leading to infection at the implant site, accompanied by decreased penetration of antibiotics and reduced blood supply (Rameshbabu and Prasad Rao 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In this study crystalline Ag-HAp nanorods have been synthesized at 100°C using a modified sol-gel method followed by dialysis (Jadalannagari et al 2011). This material exhibits good antimicrobial activity against E. coli and S. aureus, along with good hemocompatibility, and therefore could be a potential candidate for bone tissue engineering applications (Chen et al 2006). …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

et al. 2013

View full text Add to dashboard Cite

Silver doped hydroxyapatite (Ag x Ca 100-x (PO 4 ) 6 (OH) 2 ) nanorods were synthesized using a modified sol gel method at a low temperature of 100°C. Silver concentration was varied as x = 1, 3 and 5. X-ray diffraction studies showed that the synthesized silver doped hydroxyapatite (Ag-HAp) was fully crystalline with hexagonal structure and an average crystallite size of 25 nm. At all the doping concentrations, the nanoparticles were rod shaped with an average length of 110-180 nm and diameter of 20-25 nm as determined from transmission electron microscopy (TEM) studies. These compounds were tested for their antimicrobial activities against E. coli (MTCC 2345) and S. aureus (MTCC 737). Antimicrobial activity was observed for all the three silver doping concentrations with the highest activity for x = 3, in terms of the zone of inhibition and the percentage reduction in the number of colonies. Hemolysis ratios for x = 1 and 3 Ag-HAp samples were below 2 %, indicating that they are highly hemocompatible and can be a promising biomaterial for tissue engineering applications in orthopedics.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Feng et al (1998) showed that biofilms of hydroxyl apatite saturated with silver resulted in remarkable antibacterial properties against positive and negative bacteria (43). Additionally, Chen et al (2006) found that the application of hydroxyl apatite including silver showed a similar intensity of cellular toxicity in vivo when compared to in vitro for Staphylococcus epidermis and Staphylococcus aureus with highly decreased numbers (44).…”

Section: Discussionmentioning

confidence: 99%

Bactericidal Activity of Copper Oxide Nanocomposite/Bioglass for in Vitro Clindamycin Release in Implant Infections Due to Staphylococcus aureus

Alijanian¹,

Talebian²,

Doudi³

2016

Avicenna J Med Biochem

View full text Add to dashboard Cite

Background: In recent years, bioactive bioceramics such as bioglass and hydroxyapatite (HA) have been introduced as a remarkable development in the field of medicine due to their bio-adaptability, non-toxicity, and persistence, in vivo. They have many potential applications in the repair of bone defects and hence they have attracted significant interest from scholars. Objectives: The aim of this study was to synthesize inorganic matrix CuO-based bioglasses and evaluate their antibacterial activity against aerobic bacterial infections in bone implants. Methods: Nano-composite samples of silica-based bioactive glass, 60S BG with nano-powder CuO, were synthesized using the sol-gel method and then assessed with regard to their antibacterial properties against Staphylococcus aureus using well diffusion agar. The samples included BG58S (58%SiO2, 36%CaO, 6%P2O5), BG/10CuO (58%SiO2, 26%CaO, 6%P2O5, 10%CuO), and BG/20CuO (48%SiO2, 26%CaO, 6%P2O5, 20%CuO). To evaluate their bioactivity, the prepared samples of BG/20CuO, BG/10CuO, and BG58S were immersed in simulated body fluids (SBF). The surface morphology and structure of the samples before and after immersion in the SBF were characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR), respectively. Then, the BG/20CuO and BG/10CuO samples were loaded in clindamycin, an antibiotic widely used in the treatment of osteomyelitis, and their release profiles were studied in phosphate buffer solution. Results: It was observed that the growth inhibition zone increased through clindamycin release due to the increasing CuO percentage in the nanocomposite of bioactive glass. The bioactivity of the nanocomposite/bioglass with CuO was superior to that of bioglass alone. In this study, the BG/20CuO sample showed a sustained release of clindamycin, which is sufficient for a drug delivery system. Conclusions: Increasing the Cu nanoparticles in bioactive glass samples leads to the release of Cu 2+ , which has a positive effect on the antibacterial mechanism, as well as decreasing the cultured Staphylococcus colonies found on the bioglasses. Therefore, it seems that the nanocomposite/bioglass of CuO is a promising option for aerobic bacterial inhibitor systems in common bone implant infections.

show abstract

In Vitro Properties of Ag‐Containing Calcium Phosphates

Gokcekaya

Ueda

Narushima

et al. 2017

Ceramic Engineering and Science Proceedings

View full text Add to dashboard Cite

In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating

Cited by 551 publications

References 65 publications

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

Bactericidal Activity of Copper Oxide Nanocomposite/Bioglass for in Vitro Clindamycin Release in Implant Infections Due to Staphylococcus aureus

In Vitro Properties of Ag‐Containing Calcium Phosphates

Contact Info

Product

Resources

About