In-vitro anti-cancer activity of shape controlled silver nanoparticles (AgNPs) in various organ specific cell lines

Yeasmin, Sabina; Datta, Hemanta Kumar; Chaudhuri, Surabhi; Malik, Debasish; Bandyopadhyay, Abhijit

doi:10.1016/j.molliq.2017.06.047

Cited by 42 publications

(16 citation statements)

References 58 publications

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“…AgNPs with smaller size can elicit enhanced endocytosis, and induce more significant cytotoxicity and genotoxicity. Compared with other shapes, spherical AgNPs exhibit better cytotoxicity due to the higher surface-to-volume ratio 216 . And higher dose of AgNPs usually leads to more apoptosis than lower one.…”

Section: Medical Applications Of Agnpsmentioning

confidence: 99%

“…Though AgNPs with various shapes are prepared, such as sphere, triangle, cuboid, rod, tube, disk and wire, only a few among these are chosen for anticancer therapy. The cellular uptakes of AgNPs, as well as particle-to-cell or particle-to-protein interactions, are partly dependent on the shape of nanoparticles 216 , 222 . In general, spherical AgNPs may display stronger endocytosis and more active anticancer effect than other shapes.…”

Section: Medical Applications Of Agnpsmentioning

confidence: 99%

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Silver nanoparticles: Synthesis, medical applications and biosafety

et al. 2020

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Silver nanoparticles (AgNPs) have been one of the most attractive nanomaterials in biomedicine due to their unique physicochemical properties. In this paper, we review the state-of-the-art advances of AgNPs in the synthesis methods, medical applications and biosafety of AgNPs. The synthesis methods of AgNPs include physical, chemical and biological routes. AgNPs are mainly used for antimicrobial and anticancer therapy, and also applied in the promotion of wound repair and bone healing, or as the vaccine adjuvant, anti-diabetic agent and biosensors. This review also summarizes the biological action mechanisms of AgNPs, which mainly involve the release of silver ions (Ag + ), generation of reactive oxygen species (ROS), destruction of membrane structure. Despite these therapeutic benefits, their biological safety problems such as potential toxicity on cells, tissue, and organs should be paid enough attention. Besides, we briefly introduce a new type of Ag particles smaller than AgNPs, silver Ångstrom (Å, 1 Å = 0.1 nm) particles (AgÅPs), which exhibit better biological activity and lower toxicity compared with AgNPs. Finally, we conclude the current challenges and point out the future development direction of AgNPs.

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Section: Medical Applications Of Agnpsmentioning

confidence: 99%

Section: Medical Applications Of Agnpsmentioning

confidence: 99%

Silver nanoparticles: Synthesis, medical applications and biosafety

et al. 2020

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“…They stabilized the shape of spherical silver nanoparticles by interaction with natural gum and then screened against cervical cancer cell lines (HeLa), lung cancer (A549), and mice macrophage or RAW 264.7 and found that the particles effectively killed these cell lines in a dose-dependent manner. 290 Venil et al reported flexirubin (a bacterial pigment)-mediated silver nanoparticles for the first time that were highly cytotoxic (IC 50 value of 36 μg/mL) against human breast cancer cell lines (MCF-7). 291 Nowadays, chitosan-based biosynthesized silver nanoparticles are mostly synthesized and used against different cancer cell lines.…”

Section: Anticancer Property Of Agnpsmentioning

confidence: 99%

Nanosilver: new ageless and versatile biomedical therapeutic scaffold

Khan¹,

Saleh²,

Wahab³

et al. 2018

IJN

170

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Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer. The mechanism of action of AgNPs in different biological systems still remains enigmatic. Here, due to limited available literature, we only focused on AgNPs mechanism in biological systems including human (wound healing and apoptosis), bacteria, and viruses which may open new windows for future research to ensure the versatile application of AgNPs in cosmetics, electronics, and medical fields.

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“…A report by Jeyaraj et al () showed in vitro cytotoxicity of biogenic AgNPs against MCF‐7 (human breast cancer) cells and similar work by Jinu et al () reported AgNPs/ Cineraria prosposis leaf extract, led to the 50% death of MCF7. Other literature refers to the anticancer activity of AgNPs (Castro‐Aceituno et al, ; Datta, Chaudhuri, Malik, & Bandyopadhyay, ; Moulton et al, ; Venkatesan, Subramanian, Tumala, & Vellaichamy, ; Venugopal et al, ).…”

Section: Beneficial Effects Of Silver Nanoparticlesmentioning

confidence: 99%

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

Flores-López

Espinoza-Gómez

Somanathan

2018

J of Applied Toxicology

211

110

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The industry of nanotechnology has had a rapid development in the last decades. In particular, silver nanoparticles (AgNPs) have unique properties so they can be used in different industrial applications, mainly in areas such as electronics, environment, medicine, biosensors and biotechnology; as well as household and healthcare-related products, like cosmetics, due to their antimicrobial properties. These beneficial effects are also offset by the higher chemical reactivity of these NPs due to their surface area to volume ratio, leading to the increased formation of reactive oxygen species (ROS) within cells. AgNPs, however, have a dark side: they increase the formation of reactive oxygen species (ROS). With increased human exposure to AgNPs, the risk and safety standards have attracted much attention. This review highlights the beneficial and toxicological effects of AgNPs in terms of cytotoxicity and genotoxicity.

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In-vitro anti-cancer activity of shape controlled silver nanoparticles (AgNPs) in various organ specific cell lines

Cited by 42 publications

References 58 publications

Silver nanoparticles: Synthesis, medical applications and biosafety

Silver nanoparticles: Synthesis, medical applications and biosafety

Nanosilver: new ageless and versatile biomedical therapeutic scaffold

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

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