In vitro anti-HIV-1 properties of ethnobotanically selected South African plants used in the treatment of sexually transmitted diseases

Tshikalange, Thilivhali Emmanuel; Meyer, J.J.M.; Lall, Namrita; Muñóz, Eduardo; Sancho, Rocı́o; Venter, Maryna van de; Oosthuizen, Vaughan

doi:10.1016/j.jep.2008.08.027

Cited by 49 publications

(31 citation statements)

References 31 publications

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“…Table 1 presents the ethnobotanical inventory with detailed information (local names, family names, parts used, preparation method, medicinal uses, and use report, frequency citation (FC) and relative frequency citation (RFC). The highest use report was reported for Combretum collinum (4), while the FC and RFC values (15) were highest in 12 plants.…”

Section: Resultsmentioning

confidence: 92%

An Ethnobotanical Study of Medicinal Plants Used in Villages Under Jongilanga Tribal Council, Mpumalanga, South Africa

Tshikalange

Mophuting

Mahore³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: Medicinal plants remain an integral part of the lives of people in rural areas. The aim of this study was to document information about the medicinal plants used by Shangaan people in villages under Jongilanga tribal council, Bushbuckridge municipality, Mpumalanga Province, South Africa. Materials and Methods: An ethnobotanical survey of medicinal plants was conducted using a semi-structured questionnaire with 15 traditional healers as informants; one of them also served as a field guide during data collection. Results were analysed by using various quantitative indices of information consensus factor (ICF), use report (UR), frequency citation (FC) and relative frequency citation (RFC). Results and Methods:The study reported 86 medicinal plants used in villages for the treatment of various ailments, the majority (25 species) of which were used for urino-genital disorders. The Fabaceae family was the most represented family (17 species) of all the medicinal plants recorded in this study. The roots were the most frequently used plant part, accounting for 56% of the plants reported, and decoctions were often used in the preparation of herbal remedies. Respiratory diseases had the highest ICF value recorded among the 8 categories of ailments. The highest use report was reported for Combretum collinum (4), while the FC and RFC values (15) were highest in 12 plant species. The study revealed that medicinal plants are still widely used in rural areas and this documentation can serve as an ethno pharmacological basis for selecting plants with potential pharmaceutical properties.

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Section: Resultsmentioning

confidence: 92%

An Ethnobotanical Study of Medicinal Plants Used in Villages Under Jongilanga Tribal Council, Mpumalanga, South Africa

Tshikalange

Mophuting

Mahore³

et al. 2016

Afr J Tradit Complement Altern Med

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“…Of interest is the fact that Pteronia divaricata did not display any in vitro hypoglycaemic activity but did show some ␣-glucosidase and ␣-amylase inhibiting action, indicating a possible different mechanism through which it could function as an anti-diabetic treatment. Tshikalange (2007) isolated various triterpenoides such as lup-20(30)-ene-3,29-diol, (3␣)-(9Cl), lup-20(29)-ene-30-hydroxy-(9Cl), taraxastanonol and ␤-sitosterol and a phenolic derivative and depside namely ataric acid and atranorin from Elaeodendron transvaalense, these substances were however not tested for their anti-diabetic activity, except ␤-sisosterol that demonstrated ␣-glucosidase and ␣-amylase inhibition (Nkobole, 2009). Drewes and Mashimbye (1993) isolated the phenolic compound, elaeocyanidin as well as the gallotannins and ouratea proanthocyanidin A from Elaeodendron transvaalense and it is likely that these compounds are responsible for the hypoglycaemic activity (Gruendel et al, 2007;Gorelik et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Deutschländer

Venter

Roux

et al. 2009

Journal of Ethnopharmacology

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a b s t r a c tAim: To validate plant species for hypoglycaemic activity. Materials and methods: Four plants were investigated for hypoglycaemic activity by evaluating inhibiting effects on carbohydrate-hydrolising enzymes: ␣-glucosidase and ␣-amylase. Acetone plant extracts were screened against C2C12 myocytes, 3T3-L1 preadipocytes and Chang liver cells by measuring glucose uptake. Cytotoxicity was done in preadipocytes and hepatocytes. Results: Extract of Euclea undulata rootbark exhibited highest activity, displaying a glucose uptake of 162.2% by Chang liver cells at 50 g/ml. An inhibition concentration of 50% for Euclea undulata was found to be 49.95 g/ml for ␣-glucosidase and 2.8 g/ml for ␣-amylase. No cytotoxicity was recorded for Euclea undulata, while Schkuhria pinnata and Elaeodendron transvaalense exhibited cytotoxicity at 12.5 g/ml. ␣-Glucosidase and ␣-amylase assays showed inhibitory activity on enzymes for three plant extracts. Conclusion: Euclea undulata, Schkuhria pinnata and Elaeodendron transvaalense showed in vitro hypoglycaemic activity. Schkuhria pinnata and Elaeodendron transvaalense indicated cytotoxicity on 3T3-L1 preadipocytes and Chang liver cells. Euclea undulata, Pteronia divaricata and Elaeodendron transvaalense inhibited ␣-glucosidase and ␣-amylase enzymes. Ethnopharmacological relevance: Screening of plant extracts scientifically validated traditional use of Euclea undulata for treatment of diabetes. Cytotoxicity results revealed that acetone extracts of Schkuhria pinnata and Elaeodendron transvaalense are toxic and raise concern for chronic use.

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“…Since the fragments of lactoferrin like lactoferricin have high potency in some biological activities, fragments of the other milk proteins may likewise have considerable antiviral activity and can be chemically synthesized and used instead of the parent milk proteins. A great deal of effort has been directed to the search of natural products with suppressive activity on various viruses (Harnett et al 2005;Tshikalange et al 2008;Klos et al 2009;Ghosh et al 2010;Chen et al 2013;Mulder et al 2013;Shin et al 2013;Alfajaro et al 2014;Wang et al 2014;Xu et al 2014;Dang et al 2015). We have in milk a combination of proteins with activity against a diversity of viruses.…”

Section: Discussionmentioning

confidence: 99%

Antiviral activities of whey proteins

Cheung

Wong

et al. 2015

Appl Microbiol Biotechnol

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Milk contains an array of proteins with useful bioactivities. Many milk proteins encompassing native or chemically modified casein, lactoferrin, alpha-lactalbumin, and beta-lactoglobulin demonstrated antiviral activities. Casein and alpha-lactalbumin gained anti-HIV activity after modification with 3-hydroxyphthalic anhydride. Many milk proteins inhibited HIV reverse transcriptase. Bovine glycolactin, angiogenin-1, lactogenin, casein, alpha-lactalbumin, beta-lactoglobulin, bovine lactoferrampin, and human lactoferrampin inhibited HIV-1 protease and integrase. Several mammalian lactoferrins prevented hepatitis C infection. Lactoferrin, methylated alpha-lactalbumin and methylated beta-lactoglobulin inhibited human cytomegalovirus. Chemically modified alpha-lactalbumin, beta-lactoglobulin and lysozyme, lactoferrin and lactoferricin, methylated alpha-lactalbumin, methylated and ethylated beta-lactoglobulins inhibited HSV. Chemically modified bovine beta-lactoglobulin had antihuman papillomavirus activity. Beta-lactoglobulin, lactoferrin, esterified beta-lactoglobulin, and esterified lactoferrindisplayed anti-avian influenza A (H5N1) activity. Lactoferrin inhibited respiratory syncytial virus, hepatitis B virus, adenovirus, poliovirus, hantavirus, sindbis virus, semliki forest virus, echovirus, and enterovirus. Milk mucin, apolactoferrin, Fe(3+)-lactoferrin, beta-lactoglobulin, human lactadherin, bovine IgG, and bovine kappa-casein demonstrated antihuman rotavirus activity.

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In vitro anti-HIV-1 properties of ethnobotanically selected South African plants used in the treatment of sexually transmitted diseases

Cited by 49 publications

References 31 publications

An Ethnobotanical Study of Medicinal Plants Used in Villages Under Jongilanga Tribal Council, Mpumalanga, South Africa

An Ethnobotanical Study of Medicinal Plants Used in Villages Under Jongilanga Tribal Council, Mpumalanga, South Africa

Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Antiviral activities of whey proteins

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