In vitro Anti-hypertensive, Antioxidant and Anticoagulant Activities of Extracts from Haliotis discus hannai

김학렬,; 강성국,; 김인철,; 김선재,; 김두운,; 마승진,; 고천성,; 이화,; 김민정,; 이태훈,; 함경식,

doi:10.3746/jkfn.2006.35.7.835

Cited by 22 publications

(3 citation statements)

References 6 publications

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“…Abalone is often called as 'The emperor of the seashells' in Korea and mostly consumed as stamina food for sick and weak individuals because of its high content of proteins and vitamins [5]. Abalone mainly live on sea weeds that contain rich and concentrated nutritional components [2].…”

Section: Discussionmentioning

confidence: 99%

“…Apart from its known nutritional importance, there are not many studies on the effects of the abalone visceral extract. One of the known effects of abalone visceral extract is its antioxidant activity as demonstrated [4,5]. However, there are still few in vivo evidence and no detailed action mechanisms for its anti-tumor effects [7].…”

Section: Discussionmentioning

confidence: 99%

“…There are some previous reports that the body and visceral portion of Haliotis discus hannai showed in vitro antioxidant activity [4,5]. Antioxidants are present in abundance in the dietary substances and their potent chemopreventive effects against many type of cancers have been reported [6].…”

Section: Introductionmentioning

confidence: 99%

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Abalone visceral extract inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity

Lee

Kwon

Ryu

et al. 2010

BMC Complement Altern Med

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BackgroundAbalone has long been used as a valuable food source in East Asian countries. Although the nutritional importance of abalone has been reported through in vitro and in vivo studies, there is little evidence about the potential anti-tumor effects of abalone visceral extract. The aim of the present study is to examine anti-tumor efficacy of abalone visceral extract and to elucidate its working mechanism.MethodsIn the present study, we used breast cancer model using BALB/c mouse-derived 4T1 mammary carcinoma and investigated the effect of abalone visceral extract on tumor development. Inhibitory effect against tumor metastasis was assessed by histopathology of lungs. Cox-2 productions by primary and secondary tumor were measured by real-time RT-PCR and immunoblotting (IB). Proliferation assay based on [3H]-thymidine incorporation and measurement of cytokines and effector molecules by RT-PCR were used to confirm tumor suppression efficacy of abalone visceral extract by modulating cytolytic CD8+ T cells. The cytotoxicity of CD8+ T cell was compared by JAM test.ResultsOral administration of abalone visceral extract reduced tumor growth (tumor volume and weight) and showed reduced metastasis as confirmed by decreased level of splenomegaly (spleen size and weight) and histological analysis of the lung metastasis (gross analysis and histological staining). Reduced expression of Cox-2 (mRNA and protein) from primary tumor and metastasized lung was also detected. In addition, treatment of abalone visceral extract increased anti-tumor activities of CD8+ T cells by increasing the proliferation capacity and their cytolytic activity.ConclusionsOur results suggest that abalone visceral extract has anti-tumor effects by suppressing tumor growth and lung metastasis through decreasing Cox-2 expression level as well as promoting proliferation and cytolytic function of CD8+ T cells.

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Section: Discussionmentioning

confidence: 99%