In Vitro Anti-infective and Antioxidant Activity of Plumbago zeylanica Linn.

Apenteng, John Antwi; Brookman-Amissah, Marianne Gloria; Osei-Asare, Christina; Oppong, Esther Eshun; Ogundeyi, Monilola

doi:10.20546/ijcrbp.2016.308.020

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…Similarly, MEXA leaves significantly inhibited DPPH radical with IC 50 value of 128.3 g/mL. A similar finding was reported by Apenteng et al (14) showing that the ethanol extracts of X. aethiopica fruit (IC 50 0.3612 g/mL) had greater DPPH scavenging potential when compared to the leaves (138.1 g/mL).…”

Section: Discussionsupporting

confidence: 84%

“…Although, several studies carried out on X. aethiopica have focussed on the fruit, very little is known about the antioxidant potential of the methanol extract of the leaves. However, very recently, Apenteng et al (14) reported the DPPH scavenging potentials of the ethanol extracts of the fruit and leaves of X. aethiopica. Furthermore, this study assessed the phytochemical content and the antioxidant potentials of the methanol extract of X. aethiopica leaves, with the view to provide a scientific basis for its therapeutic purpose in the treatment and management of cough, malaria, fibroid, amenorrhoea and sickle cell anaemia.…”

Section: Discussionmentioning

confidence: 99%

“…X. aethiopica contains a number of essential oil (7). Different studies have shown the analgesic, anti-inflammatory, antiallergic, anticancer and antioxidant properties of X. aethiopica fruit and leaves extracts (7,(13)(14)(15). However, there is a need to obtain information on the phytochemical constituents and antioxidant properties of the methanol extract of the leaves of X. aethiopica.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Potential of Methanol Extract of Xylopia aethiopica Leaves

Oyedeji,

Ehigie,

Nwaechefu

2018

JBMS

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Background: Plants possess an array of phytochemicals and are mostly used in the treatment of diseases associated with high levels of reactive oxygen species (ROS). Xylopia aethiopica is a plant widely found in tropical Africa and used traditionally as spices in food and for the treatment of skin infection in Nigeria. The leaves are used in the management of boils, wounds, cough and menstrual pain in women. Objective: This study assessed the phytochemicals and antioxidant potentials of the methanol extract of X. aethiopica (MEXA) leaves. Methods: The leaves of X. aethiopica were extracted with methanol. Qualitative phytochemical screening, total phenolic and total flavonoid contents were determined. In vitro antioxidant potential of the methanol extract of X. aethiopica leaves was assessed by evaluating its reducing power, the extent of inhibition of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 1,1, Diphenyl 2, picrylhydrazyl (DPPH), hydroxyl (OH), nitric oxide (NO) and lipid peroxidation. Results: The result of the phytochemical screening of the MEXA leaves showed the presence of alkaloids, glycosides and polyphenols. Total phenolic and total flavonoid contents were 49.42±2.7 mg/GAE/100 g and 28.3±1.8 mg/QE/100 g, respectively. Also, the reducing power of MEXA leaves increased with increasing concentration of the extract. Furthermore, MEXA leaves significantly (p< 0.05) inhibited ABTS, DPPH, hydroxyl and nitric oxide radicals in a concentration-dependent manner. The extract also significantly (p<0.05) inhibited Fe2+-induced lipid peroxidation in a concentration-dependent manner. Conclusion: This study demonstrated that the methanol extract of Xylopia aethiopica leaves possesses potent phytochemicals which could significantly scavenge free radicals and may be useful in treatment of diseases associated with high levels of reactive oxygen species.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant Potential of Methanol Extract of Xylopia aethiopica Leaves

Oyedeji,

Ehigie,

Nwaechefu

2018

JBMS

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“…The ethyl acetate extracts showed significant (p < 0.0001) concentration-dependent anthelminthic activity with the highest effect at 300 mg/mL causing paralysis at 7.39 ± 0.94 min and death at 11.81 ± 1.10 min. The methanol extract at 300 mg/mL demonstrated slightly lower anthelmintic effect with paralysis at 17.23 ± 1.68 min and death at 21.83 ± 2.60 min [62].…”

Section: Plumbago Zeylanica Linn (Plumbaginaceae)mentioning

confidence: 92%

The Ghanaian Flora as a Potential Source of Anthelmintic and Anti-Schistosomal Agents

Asante-Kwatia¹,

Mensah²,

Gyimah³

et al. 2022

Natural Medicinal Plants

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Parasitic infections including schistosomiasis and soil transmitted helminthiasis are the most commonly encountered Neglected Tropical Diseases (NTDs) in the world. These diseases remain a major public health concern affecting millions of people especially those living in poor regions where access to effective conventional health care is a challenge. Interventions to control these infections in endemic areas have not been successful due to the high cost of drugs, limited availability as well as inequity of access to preventive chemotherapies. Another problem is the development resistance to the limited number of recommended medications due to their intensive use in both human and live-stock. There is an increasing awareness of the potential of natural products as chemotherapeutic agents to combat parasitic infections. Natural products may offer an unlimited source of chemically diverse drug molecules which may be safe, efficient, less toxic, less expensive and readily available for use especially in low-income countries. The Ghanaian flora provides such a ready source for new therapeutic interventions for the local population. Several researches have provided evidence of the anti-parasitic activity of Ghanaian medicinal plants. This chapter provides a review with special focus on medicinal plants collected from Ghana with anthelmintic and anti-schistosomal activity. Evidence of pharmacological activities of crude extracts, fractions and bioactive phytoconstituents as well as possible mechanisms of action where investigated are discussed.

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Anthelmintic Agents from African Medicinal Plants: Review and Prospects

Jato

Orman

Boakye

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Soil-transmitted helminthiasis affects more than 1.5 billion people globally and largely remains a sanitary problem in Africa. These infections place a huge economic burden on poor countries and affect livestock production, causing substantial economic losses and poor animal health. The emergence of anthelmintic resistance, especially in livestock, and the potential for its widespread in humans create a need for the development of alternative therapies. Medicinal plants play a significant role in the management of parasitic diseases in humans and livestock, especially in Africa. This report reviews anthelmintic studies that have been conducted on medicinal plants growing in Africa and published within the past two decades. A search was made in various electronic databases, and only full articles in English were included in the review. Reports show that aqueous and hydroalcoholic extracts and polar fractions obtained from these crude extracts form the predominant (80%) form of the extracts studied. Medicinal plants, extracts, and compounds with different chemical groups have been studied for their anthelmintic potential. Polyphenols and terpenoids are the most reported groups. More than 64% of the studies employed in vitro assays against parasitic and nonparasitic nematode models. Egg hatch inhibition, larval migration inhibition, and paralysis are the common parameters assessed in vitro. About 72% of in vivo models involved small ruminants, 15% rodents, and 5% chicken. Egg and worm burden are the main factors assessed in vivo. There were no reports on interventions in humans cited within the period under consideration. Also, few reports have investigated the potential of combining plant extracts with common anthelmintic drugs. This review reveals the huge potential of African medicinal plants as sources of anthelmintic agents and the dire need for in-depth clinical studies of extracts, fractions, and compounds from African plants as anthelmintic agents in livestock, companion animals, and humans.

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In Vitro Anti-infective and Antioxidant Activity of Plumbago zeylanica Linn.

Cited by 3 publications

References 6 publications

Antioxidant Potential of Methanol Extract of Xylopia aethiopica Leaves

Antioxidant Potential of Methanol Extract of Xylopia aethiopica Leaves

The Ghanaian Flora as a Potential Source of Anthelmintic and Anti-Schistosomal Agents

Anthelmintic Agents from African Medicinal Plants: Review and Prospects

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