In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans

García–Lafuente, Ana; Moro, Carlos; Manchón, N.; Gonzalo-Ruiz, A.; Villares, Ana; Guillamón, Eva; Rostagno, Maurı́cio A.; Mateo-Vivaracho, Laura

doi:10.1016/j.foodchem.2014.04.004

Cited by 99 publications

(68 citation statements)

References 31 publications

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“…NF-κB pathway was reported to be related to the immune responses and inflammation responses in macrophages2526. The activation of NF-κB is often required for the upregulation of pro-inflammatory mediators, such as, iNOS, TNF-α, and IL-6, in LPS-induced RAW264.7 macrophages, so the effect of neoagarotetraose on LPS-induced NF-κB activation was also evaluated by western blot.…”

Section: Resultsmentioning

confidence: 99%

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Neoagaro-oligosaccharide monomers inhibit inflammation in LPS-stimulated macrophages through suppression of MAPK and NF-κB pathways

Wang

Liu

Hao

et al. 2017

Sci Rep

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Neoagaro-oligosaccharides derived from agarose have been demonstrated to possess a variety of biological activities, such as anti-bacteria and anti-oxidative activities. In this study, we mainly explored the inhibitory effects and the mechanisms of neoagaro-oligosaccharide monomers against LPS-induced inflammatory responses in mouse macrophage RAW264.7 cells. The results indicated that neoagaro-oligosaccharide monomers especially neoagarotetraose could significantly reduce the production and release of NO in LPS-induced macrophages. Neoagarotetraose significantly suppressed the expression and secretion of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines such as TNF-α and IL-6. The inhibition mechanisms may be associated with the inhibition of the activation of p38MAPK, Ras/MEK/ERK and NF-κB signaling pathways. Thus, neoagarotetraose may attenuate the inflammatory responses through downregulating the MAPK and NF-κB signaling pathways in LPS-stimulated macrophages. In summary, the marine-derived neoagaro-oligosaccharide monomers merit further investigation as novel anti-inflammation agents in the future.

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Section: Resultsmentioning

confidence: 99%

“…NF-κB pathway was reported to be related to the immune responses and inflammation responses in macrophages2526. The activation of NF-κB which mediated by the NF-κB translocation dependent pathway30 or the phosphorylation of MAPK signaling31 is required for the upregulation of pro-inflammatory mediators in LPS-induced RAW264.7 cells.…”

Section: Discussionmentioning

confidence: 99%

Neoagaro-oligosaccharide monomers inhibit inflammation in LPS-stimulated macrophages through suppression of MAPK and NF-κB pathways

Wang

Liu

Hao

et al. 2017

Sci Rep

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“…In vitro studies have also shown that phenolic compounds found in beans may play a role in modulating incidences of various chronic diseases by the protective effects of antioxidants (Garcia-Lafuente, Moro, Manchon, Gonzalo-Ruiz, Villares, Guillamon, et al, 2014). Studies on lipophilic phytochemicals such as fatty acids, carotenoids and tocopherols in dry beans are rather limited (Wu, Beecher, Holden, Haytowitz, Gebhardt, & Prior, 2004).…”

Section: Introductionmentioning

confidence: 99%

Characterization of free, conjugated and bound phenolics and lipophilic antioxidants in regular- and non-darkening cranberry beans (Phaseolus vulgaris L.)

et al. 2015

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“…These foods provide additional therapeutic value to humans beyond the basic nutritive value. Beans and their extracts have been investigated and shown to exhibit immunomodulatory, antiproliferative, antitumor, antioxidant, antifungal, HIV‐1 reverse transcriptase activities (Fang and others ; Lam and Ng ; Chan and Ng ; Chan and others ; López and others ; García‐Lafuente and others ).…”

Section: Introductionmentioning

confidence: 99%

Amino Acid, Organic Acid, and Sugar Profiles of 3 Dry Bean (Phaseolus vulgaris L.) Varieties

John

Luthria

2015

Journal of Food Science

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In this study, we compared the amino acid, organic acid and sugar profiles of 3 different varieties of dry beans (black bean [BB], dark red bean [DRB], and cranberry bean [CB]). The efficiency of the 2 commonly used extraction solvents (water and methanol:chloroform:water [2.5:1:1, v/v/v/]) for cultivar differentiation based on their metabolic profile was also investigated. The results showed that the BB contained the highest concentration of amino acids followed by DRB and CB samples. Phenylalanine, a precursor for the biosynthesis of phenolic secondary metabolites was detected at low concentration in CB samples and correlated with the reduced anthocyanins content in CB extract as documented in the published literature. Comparing the extractability of 2 extraction solvents, methanol:chloroform:water (2.5:1:1, v/v/v/) showed higher recoveries of amino acids from 3 beans, whereas, sugars were extracted in higher concentration with water. Analytically, gas chromatography detected sugars (9), amino acids (11), and organic acids (3) in a single run after derivatization of the extracts. In comparison, ion chromatography detected only sugars in a single run without any derivatization step with the tested procedure. Bean samples are better differentiated by the sugar content extracted with water as compared to the aqueous organic solvent extracts using partial least-square discriminant analysis.

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In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans

Cited by 99 publications

References 31 publications

Neoagaro-oligosaccharide monomers inhibit inflammation in LPS-stimulated macrophages through suppression of MAPK and NF-κB pathways

Neoagaro-oligosaccharide monomers inhibit inflammation in LPS-stimulated macrophages through suppression of MAPK and NF-κB pathways

Characterization of free, conjugated and bound phenolics and lipophilic antioxidants in regular- and non-darkening cranberry beans (Phaseolus vulgaris L.)

Amino Acid, Organic Acid, and Sugar Profiles of 3 Dry Bean (Phaseolus vulgaris L.) Varieties

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